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Association of COVID-19 mortality with serum selenium, zinc and copper: Six observational studies across Europe

Demircan et al., Frontiers in Immunology, doi:10.3389/fimmu.2022.1022673
Nov 2022  
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Retrospective 551 COVID-19 patients in Europe, showing an inverse association between selenium or zinc levels and mortality.
This study includes selenium and zinc.
Demircan et al., 28 Nov 2022, retrospective, multiple countries, peer-reviewed, 24 authors.
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Association of COVID-19 mortality with serum selenium, zinc and copper: Six observational studies across Europe
Kamil Demircan, Thilo Samson Chillon, Tommy Bracken, Ilaria Bulgarelli, Irene Campi, Gijs Du Laing, Samira Fafi-Kremer, Laura Fugazzola, Alejandro Abner Garcia, Raban Heller, David J Hughes, Louis Ide, Georg Jochen Klingenberg, Pawel Komarnicki, Zbigniew Krasinski, Alain Lescure, Patrick Mallon, Arash Moghaddam, Luca Persani, Mirko Petrovic, Marek Ruchala, Morgane Solis, Linos Vandekerckhove, Lutz Schomburg
Frontiers in Immunology, doi:10.3389/fimmu.2022.1022673
Introduction: Certain trace elements are essential for life and affect immune system function, and their intake varies by region and population. Alterations in serum Se, Zn and Cu have been associated with COVID-19 mortality risk. We tested the hypothesis that a disease-specific decline occurs and correlates with mortality risk in different countries in Europe. Methods: Serum samples from 551 COVID-19 patients (including 87 nonsurvivors) who had participated in observational studies in Europe
Ethics statement The studies involving human participants were reviewed and approved by Local Ethics Committee of JPH Ghent and UZ Gent, Institutional review boards of the Strasbourg University Hospitals, Bavaria Ethik-Kommission der Bayerischen Landesärztekammer, Local Irish institutional review boards, ethics committee of Istituto Auxologico Italiano in Milan, Italy, Bioethical Committee at Poznan University of Medical Sciences. The patients/participants provided their written informed consent to participate in this study. Author contributions KD: conceptualization, methodology, software, formal analysis, investigation, data curation, writing -original draft, and visualization; TC: conceptualization, methodology, software, formal analysis, investigation, data curation, writing -original draft, and visualization; TB: conceptualization, resources, and writing -review and editing; IB: conceptualization, resources, and writing -review and editing; IC: conceptualization, resources, and writing -review and editing; GDL: conceptualization, resources, and writing -review and editing; SF-K: conceptualization, resources, and writing -review and editing; LF: conceptualization, resources, and writingreview andediting;AG:conceptualization,resources,andwriting-reviewand Conflict of interest LS holds shares of selenOmed GmbH, a company involved in selenium status assessment. The remaining authors declare that the research was conducted in the absence of any commercial or financial..
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