Factors influencing the severity of COVID-19 course for patients with diabetes mellitus in tashkent: a retrospective cohort study

{ 'indexed': {'date-parts': [[2023, 7, 27]], 'date-time': '2023-07-27T04:30:03Z', 'timestamp': 1690432203862}, 'reference-count': 74, 'publisher': 'Endocrinology Research Centre', 'issue': '2', 'license': [ { 'start': { 'date-parts': [[2023, 6, 6]], 'date-time': '2023-06-06T00:00:00Z', 'timestamp': 1686009600000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://www.omet-endojournals.ru/jour/about/editorialPolicies#openAccessPolicy'}], 'content-domain': {'domain': ['www.omet-endojournals.ru'], 'crossmark-restriction': True}, 'abstract': '<jats:p><jats:bold>BACKGROUND: </jats:bold>Since the very first outbreak, scientists have ' 'been trying to determine the most critical pathogenetic mechanisms for the development of ' 'COVID-19 and related complications, analyze individual subpopulations of patients with ' 'chronic diseases and develop optimal tactics to combat not only the infection itself but also ' 'its acute and chronic complications.</jats:p><jats:p><jats:bold>AIM:</jats:bold> to assess ' 'the COVID-19 course among patients with Type 1 and Type 2 ' 'DM.</jats:p><jats:p><jats:bold>MATERIALS AND METHODS: </jats:bold>A retrospective cohort ' 'study of Tashkent inhabitants, who had COVID-19 from April to D ecember 2020, was performed. ' 'The data were obtained from the single electronic database of registered cases of COVID-19. ' 'All data were analyzed using a logistic regression in STATA 17.0 software. Further, the ' 'matched case-control study was performed for patients with type 2 DM and no DM based on age, ' 'gender, and BMI.</jats:p><jats:p><jats:bold>RESULTS: </jats:bold>Of the 5023 analyzed ' 'subjects, 72.63% had no diabetes mellitus (DM), 4.24% had type 1 DM, 15.19% had type 2 DM, ' 'and 7.94% was diagnosed with DM during the COVID-19 infection. DM, overweight, and obesity ' 'were associated with severe COVID-19; the most significant risk of a severe course was found ' 'in persons with type 2 DM. The risk of a lethal outcome and the need for prescription of ' 'glucocorticoids did not show a significant association with diabetes in Tashkent. The ' 'clinical features of COVID-19 were more common in patients with type 2 DM, especially for ' 'shortness of breath, chest pain, and arrhythmia. The persons receiving SU have complained of ' 'dyspnea significantly more often than matched patients without DM. Metformin and DPP4i were ' 'the groups of drugs that were not associated with significantly increased risk of ' 'hospitalization of patients because of COVID-19. The matched case-control study did not ' 'reveal statistically significant differences in the disease course severity, need for ' 'hospitalization and glucocorticoids, and death depending on the glucose-lowering therapy ' 'preceding the onset of COVID-19.</jats:p><jats:p><jats:bold>CONCLUSION: </jats:bold>Diabetes, ' 'age and overweight/obesity were associated with severe course of COVID-19 in Tashkent. There ' 'was no statistical difference in COVID-19 severity depending on initial glucose-lowering ' 'therapy.</jats:p>', 'DOI': '10.14341/omet12801', 'type': 'journal-article', 'created': {'date-parts': [[2023, 7, 26]], 'date-time': '2023-07-26T13:54:47Z', 'timestamp': 1690379687000}, 'page': '92-103', 'update-policy': 'http://dx.doi.org/10.14341/crossmarkpolicy2018', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Factors influencing the severity of COVID-19 course for patients with diabetes mellitus in ' 'tashkent: a retrospective cohort study', 'prefix': '10.14341', 'volume': '20', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-4921-4494', 'authenticated-orcid': True, 'given': 'A. V.', 'family': 'Alieva', 'sequence': 'first', 'affiliation': [ { 'name': 'Republican Specialized Scientific-and-Practical Medical Centre ' 'of Endocrinology named after academician Ya.Kh.Turakulov'}]}, { 'ORCID': 'http://orcid.org/0000-0002-2865-5186', 'authenticated-orcid': True, 'given': 'A. A.', 'family': 'Djalilov', 'sequence': 'additional', 'affiliation': [{'name': 'Westminster International University in Tashkent'}]}, { 'ORCID': 'http://orcid.org/0000-0002-0926-0306', 'authenticated-orcid': True, 'given': 'F. A.', 'family': 'Khaydarova', 'sequence': 'additional', 'affiliation': [ { 'name': 'Republican Specialized Scientific-and-Practical Medical Centre ' 'of Endocrinology named after academician Ya.Kh.Turakulov'}]}, { 'ORCID': 'http://orcid.org/0000-0001-8422-9803', 'authenticated-orcid': True, 'given': 'A. 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U.', 'family': 'Alimova', 'sequence': 'additional', 'affiliation': [ { 'name': 'Republican Specialized Scientific-and-Practical Medical Centre ' 'of Endocrinology named after academician Ya.Kh.Turakulov'}]}, { 'ORCID': 'http://orcid.org/0000-0003-4683-1435', 'authenticated-orcid': True, 'given': 'M. D.', 'family': 'Aripova', 'sequence': 'additional', 'affiliation': [ { 'name': 'Republican Specialized Scientific-and-Practical Medical Centre ' 'of Endocrinology named after academician Ya.Kh.Turakulov'}]}, { 'ORCID': 'http://orcid.org/0000-0002-4708-0306', 'authenticated-orcid': True, 'given': 'A. 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