Association of metformin with mortality or ARDS in patients with COVID-19 and type 2 diabetes: A retrospective cohort study
Nan Jiang, Zhenyuan Chen, Li Liu, Xiaoxv Yin, Heping Yang, Xiangping Tan, Jing Wang, Hui Li, Mengge Tian, Zuxun Lu, Nian Xiong, Yanhong Gong
Diabetes Research and Clinical Practice, doi:10.1016/j.diabres.2020.108619
To determine the association between metformin use and mortality and ARDS incidence in patients with COVID-19 and type 2 diabetes. Methods: This study was a multi-center retrospective analysis of COVID-19 patients with type 2 diabetes and admitted to four hospitals in Hubei province, China from December 31st, 2019 to March 31st, 2020. Patients were divided into two groups according to their exposure to metformin during hospitalization. The outcomes of interest were 30-day allcause mortality and incidence of ARDS. We used mixed-effect Cox model and random effect logistic regression to evaluate the associations of metformin use with outcomes, adjusted for baseline characteristics. Results: Of 328 patients with COVID-19 and type 2 diabetes included in the study cohort, 30.5% (100/328) were in the metformin group. In the mixed-effected model, metformin use was associated with the lower incidence of ARDS. There was no significant association between metformin use and 30-day all-cause mortality. Propensity score-matched analysis
Authors' Contributions ZC, NJ, XY, LL, NX, and YG, were responsible for the conception, design, and writing of the manuscript. HY, XT, JW, HL, and MT were responsible for the acquisition of data and literature research. ZC, NJ, XY, LL, ZL were responsible for the analysis and interpretation of data. All authors reviewed and revised the manuscript and approved the final version.
Appendix A. Supplementary material Supplementary data to this article can be found online at https://doi.org/10.1016/j.diabres.2020.108619.
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