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All Studies   All Outcomes   Recent: 
0 0.5 1 1.5 2+ Mortality, day 60 12% Improvement Relative Risk Mortality 17% Ventilation 47% Recovery 9% Hospitalization time -11% c19early.org/s Ali et al. NCT04330690 CATCO Remdesivir RCT LATE Favors remdesivir Favors control
Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial
Ali et al., Canadian Medical Association Journal, doi:10.1503/cmaj.211698, CATCO, NCT04330690 (history)
19 Jan 2022    Source   PDF   Share   Tweet
RCT 1,282 hospitalized patients in Canada showing lower mechanical ventilation with remdesivir treatment, but no significant difference for mortality.
[Gérard, Zhou] show significantly increased risk of acute kidney injury with remdesivir.
risk of death, 12.0% lower, RR 0.88, p = 0.21, treatment 127 of 634 (20.0%), control 152 of 647 (23.5%), NNT 29, day 60.
risk of death, 17.0% lower, RR 0.83, p = 0.09, treatment 117 of 634 (18.5%), control 145 of 647 (22.4%), NNT 25, in hospital.
risk of mechanical ventilation, 47.0% lower, RR 0.53, p < 0.001, treatment 46 of 634 (7.3%), control 89 of 647 (13.8%), NNT 15, day 60.
risk of no recovery, 9.0% lower, RR 0.91, p = 0.41, treatment 634, control 647, clinical status, day 60.
hospitalization time, 11.1% higher, relative time 1.11, p = 0.04, treatment median 10.0 IQR 12.0 n=634, control median 9.0 IQR 11.0 n=647.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ali et al., 19 Jan 2022, Randomized Controlled Trial, Canada, peer-reviewed, 85 authors, average treatment delay 8.0 days, trial NCT04330690 (history) (CATCO).
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This PaperRemdesivirAll
Late treatment
is less effective
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