Efficacy of Chloroquine and Lopinavir/ Ritonavir in mild/general novel coronavirus (CoVID-19) infections: a prospective, open-label, multicenter randomized controlled clinical study

Xia et al., ChiCTR2000029741, Feb 2020

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https://c19early.org/xia.html

HCQ for COVID-19

1st treatment shown to reduce risk in March 2020, now with p < 0.00000000001 from 424 studies, used in 59 countries.

Lower risk for mortality, hospitalization, progression, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

6,200+ studies for 180+ treatments. c19early.org

Early results from a very small trial, reported within the application for a later trial. Very minimal details are provided, but we include this as the earliest published result. For COVID-19 patients with pneumonia the viral negative conversion rate was 50% (5/10) with CQ versus 20% (3/15) with lopinavir/ritonavir.

Standard of Care (SOC) for COVID-19 in the study country, China, is average with moderate efficacy for approved treatments1.

This study is excluded in the after exclusion results of meta analysis: minimal details provided.

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risk of no viral clearance, 37.5% lower, RR 0.62, p = 0.17, treatment 5 of 10 (50.0%), control 12 of 15 (80.0%), NNT 3.3.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

1. c19early.org, c19early.org/soc/china.html.

Xia et al., 11 Feb 2020, retrospective, China, preprint, 1 author.

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Late treatment
is less effective

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