Azvudine for the Treatment of COVID‐19 in Pre‐Existing Cardiovascular Diseases: A Single‐Center, Real‐World Experience

DOI record: { "DOI": "10.1002/advs.202306050", "ISSN": [ "2198-3844", "2198-3844" ], "URL": "http://dx.doi.org/10.1002/advs.202306050", "abstract": "<jats:title>Abstract</jats:title><jats:p>COVID‐19 can lead to adverse outcomes in patients with pre‐existing diseases. Azvudine has been approved for treating COVID‐19 in China, but the real‐world data is limited. It is aimed to investigate the efficacy of Azvudine in patients with COVID‐19 and pre‐existing cardiovascular diseases. Patients with confirmed COVID‐19 and pre‐existing cardiovascular diseases are retrospectively enrolled. The primary outcome is all‐cause death during hospitalization. Overall, 351 patients are included, with a median age of 74 years, and 44% are female. 212 (60.6%) patients are severe cases. Azvudine is used in 106 (30.2%) patients and not in 245 (69.8%). 72 patients died during hospitalization. After multivariate adjustment, patients who received Azvudine a lower risk of all‐cause death (hazard ratio: 0.431; 95% confidence interval: 0.252–0.738; <jats:italic>p</jats:italic> = 0.002) than controls. Azvudine therapy is also associated with lower risks of shock and acute kidney injury. For sensitivity analysis in the propensity score‐matched cohort (<jats:italic>n</jats:italic> = 90 for each group), there is also a significant difference in all‐cause death between the two groups (hazard ratio: 0.189; 95% confidence interval: 0.071–0.498; <jats:italic>p</jats:italic> &lt; 0.001). This study indicated that Azvudine therapy is associated with better outcomes in COVID‐19 patients with pre‐existing cardiovascular diseases.</jats:p>", "alternative-id": [ "10.1002/advs.202306050" ], "assertion": [ { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Received", "name": "received", "order": 0, "value": "2023-08-25" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Published", "name": "published", "order": 2, "value": "2024-03-27" } ], "author": [ { "affiliation": [ { "name": "Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology Wuhan 430014 China" } ], "family": "Wu", "given": "Liu", "sequence": "first" }, { "affiliation": [ { "name": "Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology Wuhan 430014 China" } ], "family": "He", "given": "Zhong‐Han", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology Wuhan 430014 China" } ], "family": "Huang", "given": "Ling", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology Wuhan 430014 China" } ], "family": "Guo", "given": "Xin", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology Wuhan 430014 China" } ], "family": "Li", "given": "Xu‐Yong", "sequence": "additional" }, { "affiliation": [ { "name": "State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing 100037 China" } ], "family": "Zhang", "given": "Hong‐Da", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology Wuhan 430014 China" } ], "family": "Chen", "given": "Man‐Hua", "sequence": "additional" } ], "container-title": "Advanced Science", "container-title-short": "Advanced Science", "content-domain": { "crossmark-restriction": true, "domain": [ "onlinelibrary.wiley.com" ] }, "created": { "date-parts": [ [ 2024, 3, 28 ] ], "date-time": "2024-03-28T05:40:33Z", "timestamp": 1711604433000 }, "deposited": { "date-parts": [ [ 2024, 3, 28 ] ], "date-time": "2024-03-28T05:40:41Z", "timestamp": 1711604441000 }, "funder": [ { "DOI": "10.13039/501100001809", "award": [ "82000064;81900334" ], "doi-asserted-by": "publisher", "name": "National Natural Science Foundation of China" } ], "indexed": { "date-parts": [ [ 2024, 3, 29 ] ], "date-time": "2024-03-29T01:18:17Z", "timestamp": 1711675097807 }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2024, 3, 27 ] ] }, "language": "en", "license": [ { "URL": "http://creativecommons.org/licenses/by/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2024, 3, 27 ] ], "date-time": "2024-03-27T00:00:00Z", "timestamp": 1711497600000 } } ], "link": [ { "URL": "https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202306050", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "311", "original-title": [], "prefix": "10.1002", "published": { "date-parts": [ [ 2024, 3, 27 ] ] }, "published-online": { "date-parts": [ [ 2024, 3, 27 ] ] }, "publisher": "Wiley", "reference": [ { "DOI": "10.1016/S0140-6736(20)30183-5", "doi-asserted-by": "publisher", "key": "e_1_2_10_1_1" }, { "DOI": "10.1016/S0140-6736(23)01003-6", "doi-asserted-by": "publisher", "key": "e_1_2_10_2_1" }, { "author": "Wenham C.", "journal-title": "BMJ Clin. 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