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0 0.5 1 1.5 2+ Mortality -100% Improvement Relative Risk Ventilation -250% Ullah et al. Remdesivir for COVID-19 LATE TREATMENT Is late treatment with remdesivir beneficial for COVID-19? Retrospective 60 patients in Pakistan Higher mortality (p=0.33) and ventilation (p=0.15), not stat. sig. Ullah et al., Int. J. Sciences, doi:10.18483/ijSci.2417 Favors remdesivir Favors control
Efficacy of Remdesivir in Covid-19 Patients; Multicenter Study in Lahore
Ullah et al., International Journal of Sciences, doi:10.18483/ijSci.2417
Ullah et al., Efficacy of Remdesivir in Covid-19 Patients; Multicenter Study in Lahore, International Journal of Sciences, doi:10.18483/ijSci.2417
Nov 2020   Source   PDF  
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Small late stage (hospitalized, <12 days symptoms) remdesivir study showing non-statistically significant higher mortality with treatment.
No adjustments were made for differences in the groups. Remdesivir mean age was 49 vs. control 57. Baseline oxygen requirement was 13.4 liters treatment vs. 10.8 control. Potential confounding by indication.
[Gérard, Wu, Zhou] show significantly increased risk of acute kidney injury with remdesivir.
risk of death, 100% higher, RR 2.00, p = 0.33, treatment 8 of 30 (26.7%), control 4 of 30 (13.3%).
risk of mechanical ventilation, 250.0% higher, RR 3.50, p = 0.15, treatment 7 of 30 (23.3%), control 2 of 30 (6.7%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ullah et al., 29 Nov 2020, retrospective, Pakistan, peer-reviewed, 8 authors.
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Abstract: Efficacy of Remdesivir in Covid-19 Patients; Multicenter Study in Lahore Najeeb Ullah1, Khurshid A Khan2, Javeid Iqbal3, Bilal Bin Younis4, Muhammad Asim Rana5, Mohsin Asif6, Aijaz Zeeshan Khan Chachar7, Falak Shan8 Abstract: Introduction: This Pandemic of Covid-19 has shaken the world and devastating and unpredictable nature of the disease and scenario becomes worse when we see limited treatment options for this disease. Objectives: The objective of the study was to assess the efficacy of Remdesivir in patients having early phase of the disease. Methodology: Study Settings: The study was conducted in two major tertiary care hospitals, Fatima Memorial Hospital, Bahria international Hospital, Lahore. Sample size & Sampling Technique: A total of 60 patients were selected for this study who were suffering from COVID 19, out of which 30 were given Remdesivir and 30 patients were kept in control group. Participants were enrolled in the study after fulfilling inclusion and exclusion criteria. It was Probability sampling. Study design: Non-randomized control interventional study. Data Analysis: Data was analyzed with respect to demographics and clinical characteristics. Outcome was observed in terms of recovery and death. Also, the oxygen requirement and respiratory rate was measured on presentation and on 14 th day of admission. Furthermore, coexisting conditions such as diabetes, hypertension, ischemic heart disease and chronic kidney disease were also considered regarding outcome in case group and control group. Results: Mean age of the study participants was 53.2 with standard deviation (SD)±14.6 years, whereas average age of cases was 49.2±15.1 and control 57.1±13.1 years. Male were 60% of the patients and 40% were females, whereas both cases and control had 57% males. The most common co existing disease was hypertension which attributed to 53% of the total sample size followed by diabetes which was present in 47% of the study participants. 23 (38%) participants did not have any coexisting disease. The data did not show any promises with Remdesivir therapy in patients with or without ventilatory support in comparison with participants who did not receive Remdesivir. Keywords: COVID 19, Pneumonia, Remdesivir
Late treatment
is less effective
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