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0 0.5 1 1.5 2+ Mortality -23% Improvement Relative Risk Remdesivir for COVID-19  Shamsi et al.  LATE TREATMENT Is late treatment with remdesivir beneficial for COVID-19? Retrospective 183 patients in Iran (March 2020 - August 2021) Study underpowered to detect differences Shamsi et al., Canadian J. Infectious .., Jul 2023 Favors remdesivir Favors control

Survival and Mortality in Hospitalized Children with COVID-19: A Referral Center Experience in Yazd, Iran

Shamsi et al., Canadian Journal of Infectious Diseases and Medical Microbiology, doi:10.1155/2023/5205188
Jul 2023  
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Retrospective 183 hospitalized pediatric COVID-19 patients in Iran, showing no significant difference in mortality with remdesivir in unadjusted results.
Gérard, Wu, Zhou show significantly increased risk of acute kidney injury with remdesivir. This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
This study includes favipiravir, vitamin D, famotidine, HCQ, aspirin, and remdesivir.
risk of death, 22.6% higher, RR 1.23, p = 0.63, treatment 8 of 53 (15.1%), control 16 of 130 (12.3%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Shamsi et al., 17 Jul 2023, retrospective, Iran, peer-reviewed, 4 authors, study period 1 March, 2020 - 1 August, 2021.
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Survival and Mortality in Hospitalized Children with COVID-19: A Referral Center Experience in Yazd, Iran
Farimah Shamsi, Mehran Karimi, Zahra Nafei, Elahe Akbarian
Canadian Journal of Infectious Diseases and Medical Microbiology, doi:10.1155/2023/5205188
Introduction. COVID-19 prognostic risk factors, therapeutic protocols, and clinical outcomes in pediatric cases are still under investigation. Materials and Methods. Tis historical cohort study evaluated the survival time of hospitalized children (1 month-18 years old) with COVID-19 admitted from March 2020 to August 2021 to an educational hospital in Yazd, Iran. Te follow-up of patients was performed at least one month after discharge. Results. From 183 hospitalized cases, 24 children were deceased. Te median age of patients was 5.41, and 54.2% were male. Te survival rate after one-month follow-up was 0.88, and the most signifcant predictors associated with survival time were the male sex, positive history of hospitalization, lymphopenia, hypoxia, and length of stay more than two weeks using Bayesian Cox regression analysis. Conclusion. Accurate estimation of the impact of predictors on poor outcomes may help healthcare providers use therapeutic protocols based on risk factors and healthcare requirements of each patient to improve their survival.
Conflicts of Interest Te authors declare that they have no conficts of interest.
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Late treatment
is less effective
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