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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Viral load 34% no CI Improvement Relative Risk Viral load (b) 50% no CI c19early.org/p Sánchez Barrueco et al. NCT04707742 Povidone-Iod.. RCT LATE Favors povidone-iodine Favors control
Effect of oral antiseptics in reducing SARS-CoV-2 infectivity: evidence from a randomized double-blind clinical trial
Sánchez Barrueco et al., Emerging Microbes & Infections, doi:10.1080/22221751.2022.2098059, NCT04707742 (history)
27 Jul 2022    Source   PDF   Share   Tweet
RCT hospitalized patients testing viral load shortly after a single mouthwash with PVP-I, hydrogen peroxide, cetylpyridinium chloride, chlorhexidine, and water. For PVP-I, there were only 5 patients with viable virus at baseline. Cross-treatment comparisons are limited due to the very small sample sizes and large difference between baseline viral loads (the baseline viral culture non-log copies/mL was ~10,000 times higher in the water group vs. PVP-I).
The trial registration shows that 160 patients were recruited, with 62 patients added in an October 6, 2021 change, however the paper presents results for only 75 patients.
risk of viral load, 33.9% lower, RR 0.66, treatment 5, control 5, relative viral culture non-log median copies/mL, 60 minutes vs. baseline.
risk of viral load, 49.9% lower, RR 0.50, treatment 5, control 5, relative viral culture non-log median copies/mL, 30 minutes vs. baseline.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sánchez Barrueco et al., 27 Jul 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Spain, peer-reviewed, mean age 55.0, 17 authors, trial NCT04707742 (history).
Contact: mira_ale@gva.es.
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Late treatment
is less effective
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