Abstract: Clinica Chimica Acta 522 (2021) 8–13
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Clinica Chimica Acta
journal homepage: www.elsevier.com/locate/cca
Previous vitamin D status and total cholesterol are associated with
Heriks Gomes Ribeiro a, 1, Raquel Costa Silva Dantas-Komatsu b, 1, Jeane Franco Pires Medeiros b,
Maria Clara da Cruz Carvalho a, Victor de Lima Soares c, Bruna Zavarize Reis d, e, *,
André Ducati Luchessi a, b, Vivian Nogueira Silbiger a, e
Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, RN, Brazil
Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil
DNA Center Laboratory, Natal, Brazil
Department of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil
Postgraduate Program in Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil
A R T I C L E I N F O
A B S T R A C T
Background: The relationship of vitamin D status and other biochemical parameters with the risk of SARS-CoV-2
infection remains inconclusive, especially in regions with high solar incidence. Therefore, we aimed to associate
the 25-hydroxyvitamin D (25(OH)D) concentrations and lipid profile prior to the SARS-CoV-2 tests in a popu
lation from a sunny region in Brazil (5 degrees S, 35 degrees W).
Methods: This retrospective cohort study enrolled 1634 patients tested for SARS-CoV-2 of a private medical
laboratory with 25(OH)D concentration and lipid profile measured ≥ 7 days before the date of the first SARSCoV-2 RT-PCR test and were categorized according to 25(OH)D sufficiency (≥30 ng/mL) or insufficiency
(<30 ng/mL). Multiple logistic regression analyses were performed to assess risk factors associated with positive
tests for SARS-CoV-2.
Results: Average serum 25(OH)D was 33.6 ng/mL. Vitamin D deficiency (<20 ng/mL) was only found in 2.6% of
the participants. Multivariate analysis demonstrated that patients > 49 y with insufficient 25(OH)D (<30 ng/mL)
presented increased odds to test positive for SARS-CoV-2 (OR: 2.02, 95 %CI: 1.15 to 3.55, P = 0.015). The same is
observed among those with total cholesterol > 190 mg/dL (OR: 1.90, 95 %CI: 1.10 to 3.28, P = 0.020).
Conclusions: Previous insufficient 25(OH)D (<30 ng/mL) concentration and high total cholesterol were associ
ated with SARS-CoV-2 infection among adults > 48 y in the study population. Further studies should be con
ducted to confirm whether measurement of 25(OH)D and lipid profile could be useful to identify patients who
are more susceptible to COVID-19.
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