Vitamin D Status and SARS-CoV-2 Infection in a Cohort of Kidney Transplanted Patients
Anna Regalia, Matteo Benedetti, Silvia Malvica, Carlo Alfieri, Mariarosaria Campise, Donata Cresseri, Maria Teresa Gandolfo, Federica Tripodi, Giuseppe Castellano, Piergiorgio Messa
Nutrients, doi:10.3390/nu14020317
Background: Recently the protective role of 25-hydroxyvitamin D (25(OH)D) against viral infections has been hypothesized. We evaluated the association between vitamin D status and SARS-CoV-2 infection susceptibility and severity in a cohort of kidney transplanted patients (KTxp). Methods: A total of 61 KTxp with SARS-CoV-2 infection (COV+) were matched with 122 healthy KTxp controls (COV−). Main biochemical parameters at 1, 6, and 12 months before SARS-CoV-2 infection were recorded. Vitamin D status was considered as the mean of two 25(OH)D measures obtained 6 ± 2 months apart during the last year. The severity of SARS-CoV-2 infection was based on the need for hospitalization (HOSP+) and death (D+). Results: 25(OH)D levels were lower in COV+ than in controls [19(12-26) vs. 23(17-31) ng/mL, p = 0.01]. No differences among the other biochemical parameters were found. The SARS-CoV-2 infection discriminative power of 25(OH)D was evaluated by ROC-curve (AUC 0.61, 95% CI 0.5-0.7, p = 0.01). 25(OH)D was not significantly different between vs. 20(15-26) ng/mL, p = 0.19] and between D+ and D− [14(6-23) vs. 20(14-26) ng/mL, p = 0.22] and had no significant correlation with disease length. Conclusions: During the year preceding the infection, 25(OH)D levels were lower in COV+ KTxp in comparison with controls matched for demographic features and comorbidities. No significant association between vitamin D status and SARS-CoV-2 infection related outcomes was found.
Informed Consent Statement: Given the observational and retrospective nature of the study, it was not necessary to obtain informed consent from patients. In any case, all of the data were collected digitally, analyzed, and reported in the results in a totally and anonymous manner.
Conflicts of Interest: The authors declare no conflict of interest.
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'abstract': '<jats:p>Background: Recently the protective role of 25-hydroxyvitamin D (25(OH)D) against '
'viral infections has been hypothesized. We evaluated the association between vitamin D status '
'and SARS-CoV-2 infection susceptibility and severity in a cohort of kidney transplanted '
'patients (KTxp). Methods: A total of 61 KTxp with SARS-CoV-2 infection (COV+) were matched '
'with 122 healthy KTxp controls (COV−). Main biochemical parameters at 1, 6, and 12 months '
'before SARS-CoV-2 infection were recorded. Vitamin D status was considered as the mean of two '
'25(OH)D measures obtained 6 ± 2 months apart during the last year. The severity of SARS-CoV-2 '
'infection was based on the need for hospitalization (HOSP+) and death (D+). Results: 25(OH)D '
'levels were lower in COV+ than in controls [19(12–26) vs. 23(17–31) ng/mL, p = 0.01]. No '
'differences among the other biochemical parameters were found. The SARS-CoV-2 infection '
'discriminative power of 25(OH)D was evaluated by ROC-curve (AUC 0.61, 95% CI 0.5–0.7, p = '
'0.01). 25(OH)D was not significantly different between HOSP+ and HOSP− [17(8–25) vs. '
'20(15–26) ng/mL, p = 0.19] and between D+ and D− [14(6–23) vs. 20(14–26) ng/mL, p = 0.22] and '
'had no significant correlation with disease length. Conclusions: During the year preceding '
'the infection, 25(OH)D levels were lower in COV+ KTxp in comparison with controls matched for '
'demographic features and comorbidities. No significant association between vitamin D status '
'and SARS-CoV-2 infection related outcomes was found.</jats:p>',
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