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0 0.5 1 1.5 2+ Chest x-ray improvemen.. 89% Improvement Relative Risk Chest x-ray improv.. (b) 65% Chest x-ray improv.. (c) 47% Viral clearance, day 10 92% Viral clearance, day 7 62% Viral clearance, day 4 48% Rahman et al. NCT04402203 Favipiravir RCT LATE TREATMENT Is late treatment with favipiravir beneficial for COVID-19? Double-blind RCT 50 patients in Bangladesh (May - July 2020) Greater improvement (p=0.0049) and improved viral clearance (p=0.00076) Rahman et al., Clinical Infection in Practice, doi:10.1016/j.clinpr.2022.100145 Favors favipiravir Favors control

Safety and Efficacy of Favipiravir for the management of COVID-19 Patients: A Randomized Control Trial

Rahman et al., Clinical Infection in Practice, doi:10.1016/j.clinpr.2022.100145, NCT04402203 (history)
Rahman et al., Safety and Efficacy of Favipiravir for the management of COVID-19 Patients: A Randomized Control Trial, Clinical Infection in Practice, doi:10.1016/j.clinpr.2022.100145, NCT04402203
May 2022   Source   PDF  
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RCT hospitalized patients in Bangladesh, showing faster recovery and viral clearance with favipiravir treatment.
risk of no chest x-ray improvement, 89.5% lower, RR 0.11, p = 0.005, treatment 1 of 19 (5.3%), control 8 of 16 (50.0%), NNT 2.2, day 10.
risk of no chest x-ray improvement, 64.9% lower, RR 0.35, p = 0.007, treatment 5 of 19 (26.3%), control 12 of 16 (75.0%), NNT 2.1, day 7.
risk of no chest x-ray improvement, 47.4% lower, RR 0.53, p = 0.001, treatment 10 of 19 (52.6%), control 16 of 16 (100.0%), NNT 2.1, day 4.
risk of no viral clearance, 91.7% lower, RR 0.08, p < 0.001, treatment 1 of 25 (4.0%), control 12 of 25 (48.0%), NNT 2.3, day 10.
risk of no viral clearance, 62.5% lower, RR 0.38, p = 0.010, treatment 6 of 25 (24.0%), control 16 of 25 (64.0%), NNT 2.5, day 7.
risk of no viral clearance, 48.0% lower, RR 0.52, p < 0.001, treatment 13 of 25 (52.0%), control 25 of 25 (100.0%), NNT 2.1, day 4.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rahman et al., 13 May 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Bangladesh, peer-reviewed, mean age 37.8, 10 authors, study period May 2020 - July 2020, trial NCT04402203 (history).
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This PaperFavipiravirAll
Safety and efficacy of favipiravir for the management of COVID-19 patients: A preliminary randomized control trial
S M Abdur Rahman, Ahmedul Kabir, Md Abm B M Abdullah, Md Billal Alam, Khan Abul Kalam Azad, Md Titu Miah, Syed Ghulam Mogni Mowla, Sudip Ranjan Deb, Mohammad Robed Amin, Muhammad Asaduzzaman
Clinical Infection in Practice, doi:10.1016/j.clinpr.2022.100145
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Table-5: Assessment of Adverse effects of patients of both groups 4%) 0 (0%) 0 (0%) 1 (4%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) Jaundice 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) Skin rash 1 (4%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) Liver damage 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 2(8%) 0 (0%) 1 (4%) Anemia 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) Vertigo 2 (8%) 2 (8%) 2 (8%) 2 (8%) 0 (0%) 2 (8%) 0 (0%) 1 (4%) Anosmia 1 (4%) 0 (0%) 1 (4%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) Conflict of Interest: The authors declared that there was no conflict of interest regarding the clinical trial. Funding: Beacon Pharmaceuticals Limited, Dhaka, Bangladesh. References Author Contributions:
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Late treatment
is less effective
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