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0 0.5 1 1.5 2+ Mortality 73% Improvement Relative Risk Vitamin C  Mosadegh et al.  LATE TREATMENT  DB RCT Is late treatment with vitamin C + combined treatments beneficial for COVID-19? Double-blind RCT 400 patients in Iran Lower mortality with vitamin C + combined treatments (p<0.000001) c19early.org Mosadegh et al., AMB Express, March 2024 Favors vitamin C Favors control

NBS superfood: a promising adjunctive therapy in critically ill ICU patients with omicron variant of COVID-19

Mar 2024  
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Vitamin C for COVID-19
6th treatment shown to reduce risk in September 2020
 
*, now known with p = 0.000000087 from 70 studies, recognized in 11 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
RCT 400 critically ill ICU patients with omicron-related ARDS showing significantly reduced mortality and inflammatory markers with a nutritional supplement containing vitamins A, B1–B3, B5, B6, B9, C, D, K, and zinc, potassium, manganese, magnesium, phosphorus, sulfur, boron, calcium, iron, copper, and other ingredients. The treatment group had significantly lower levels of CRP, ESR, D-Dimer, and CPK, and higher lymphocyte counts compared to the control group after 14 days. Mortality was 8.5% in the treatment group vs. 31% in the control group (p=0.001).
This study is excluded in meta analysis: many combined treatments which may significantly contribute to the effect seen.
Study covers vitamin C, vitamin D, vitamin B9, zinc, vitamin A, and vitamin K.
risk of death, 72.6% lower, RR 0.27, p < 0.001, treatment 17 of 200 (8.5%), control 62 of 200 (31.0%), NNT 4.4.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mosadegh et al., 24 Mar 2024, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, peer-reviewed, 12 authors, this trial uses multiple treatments in the treatment arm (combined with multiple vitamins and minerals) - results of individual treatments may vary, trial IRCT20230116057135N2. Contact: m-mosadegh@alumnus.tums.ac.ir.
This PaperVitamin CAll
NBS superfood: a promising adjunctive therapy in critically ill ICU patients with omicron variant of COVID-19
Mehrdad Mosadegh, Aref Khalkhali, Yousef Erfani, Manije Nezamdoost, Seyyed Hamid Hashemi, Farid Azizi Jalilian, Nastaran Ansari, Shahab Mahmoudvand, Mojgan Mamani, Elham Abdoli, Razieh Amini, Gholamreza Kalvandi
AMB Express, doi:10.1186/s13568-024-01690-8
This clinical trial aimed to assess the impact of Nutrition Bio-shield superfood (NBS) on clinical status among critically ill ICU patients suffering from acute respiratory distress syndrome (ARDS) due to the Omicron variant of COVID-19. A total of 400 patients with confirmed Omicron-related ARDS were randomly assigned to either the intervention group (n = 200) or the control group (n = 200). Patients in the intervention group received 1.5 g of NBS powder daily for 2 weeks in addition to standard antiviral treatment, while the control group received a placebo alongside standard antiviral therapy. Serum samples were collected from all patients in both groups, and various clinical and laboratory parameters, including ESR, CRP, D-Dimer, CPK, WBC count, lymphocyte count, and lymphocyte percentage, were measured using established methodologies. Following a 14-day intervention period, the intervention group exhibited a significant reduction in mean serum levels of CRP (15.39 vs. 48.49; P < 0.001), ESR (14.28 vs. 34.03; P < 0.001), D-Dimer (485.18 vs. 1009.13; P = 0.001), and CPK (68.93 vs. 131.48; P < 0.001) compared to the control group. Conversely, a significant increase was observed in the mean serum levels of lymphocytes (1537.06 vs. 1152.60; P < 0.001) in the intervention group after 14 days of treatment compared to the control group. The remarkable reduction in inflammatory markers and mortality rates observed with NBS supplementation alongside standard antiviral treatment underscores its crucial role in mitigating inflammation and achieving an important milestone in the fight against COVID-19.
Author contributions M. M., A. K. and Y. E.: conceptualization; data curation; formal analysis; and writing-original draft. Y. E., M. N., S. H. H., F. A. J.: conceptualization; methodology; project administration; and writing-original draft. M. M., E. A., R. A., G. K.: data curation; formal analysis; writing-original draft; and writing-review & editing. F. A. J., N. A., S. M.: language editing. Declarations Ethics approval and consent to participate The study protocols adhered to the principles outlined in the Helsinki Declaration, with all procedures receiving official validation from the Ethics Commit- Consent for publication Not applicable. Competing interests All of the authors declare that there are no commercial, personal, political, or any other potential conflicting interests related to the submitted manuscript. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Late treatment
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