NBS superfood: a promising adjunctive therapy in critically ill ICU patients with omicron variant of COVID-19

DOI record: { "DOI": "10.1186/s13568-024-01690-8", "ISSN": [ "2191-0855" ], "URL": "http://dx.doi.org/10.1186/s13568-024-01690-8", "abstract": "<jats:title>Abstract</jats:title><jats:p>This clinical trial aimed to assess the impact of Nutrition Bio-shield superfood (NBS) on clinical status among critically ill ICU patients suffering from acute respiratory distress syndrome (ARDS) due to the Omicron variant of COVID-19. A total of 400 patients with confirmed Omicron-related ARDS were randomly assigned to either the intervention group (n = 200) or the control group (n = 200). Patients in the intervention group received 1.5 g of NBS powder daily for 2 weeks in addition to standard antiviral treatment, while the control group received a placebo alongside standard antiviral therapy. Serum samples were collected from all patients in both groups, and various clinical and laboratory parameters, including ESR, CRP, D-Dimer, CPK, WBC count, lymphocyte count, and lymphocyte percentage, were measured using established methodologies. Following a 14-day intervention period, the intervention group exhibited a significant reduction in mean serum levels of CRP (15.39 vs. 48.49; P &lt; 0.001), ESR (14.28 vs. 34.03; P &lt; 0.001), D-Dimer (485.18 vs. 1009.13; P = 0.001), and CPK (68.93 vs. 131.48; P &lt; 0.001) compared to the control group. Conversely, a significant increase was observed in the mean serum levels of lymphocytes (1537.06 vs. 1152.60; P &lt; 0.001) in the intervention group after 14 days of treatment compared to the control group. The remarkable reduction in inflammatory markers and mortality rates observed with NBS supplementation alongside standard antiviral treatment underscores its crucial role in mitigating inflammation and achieving an important milestone in the fight against COVID-19.</jats:p>", "alternative-id": [ "1690" ], "article-number": "33", "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Received", "name": "received", "order": 1, "value": "6 January 2024" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "12 March 2024" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 3, "value": "24 March 2024" }, { "group": { "label": "Declarations", "name": "EthicsHeading" }, "name": "Ethics", "order": 1 }, { "group": { "label": "Ethics approval and consent to participate", "name": "EthicsHeading" }, "name": "Ethics", "order": 2, "value": "The study protocols adhered to the principles outlined in the Helsinki Declaration, with all procedures receiving official validation from the Ethics Committee of Hamadan University of Medical Sciences (Protocol Number: IR.UMSHA.REC.1401.1043; Approval Date: 2023-03-04). Additionally, the study’s protocol has been registered in the Iranian Registry of Clinical Trials (IRCT), accessible at ExternalRef removed (IRCT Registration Number: IRCT20230116057135N2; Registration Date: 2023-04-05). The aims of the study were explained to patients. A questionnaire was prepared for each of the patients and a written informed consent was acquired from all patients." }, { "group": { "label": "Consent for publication", "name": "EthicsHeading" }, "name": "Ethics", "order": 3, "value": "Not applicable." }, { "group": { "label": "Competing interests", "name": "EthicsHeading" }, "name": "Ethics", "order": 4, "value": "All of the authors declare that there are no commercial, personal, political, or any other potential conflicting interests related to the submitted manuscript." } ], "author": [ { "affiliation": [], "family": "Mosadegh", "given": "Mehrdad", "sequence": "first" }, { "affiliation": [], "family": "Khalkhali", "given": "Aref", "sequence": "additional" }, { "affiliation": [], "family": "Erfani", "given": "Yousef", "sequence": "additional" }, { "affiliation": [], "family": "Nezamdoost", "given": "Manije", "sequence": "additional" }, { "affiliation": [], "family": "Hashemi", "given": "Seyyed Hamid", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0003-3134-1441", "affiliation": [], "authenticated-orcid": false, "family": "Azizi Jalilian", "given": "Farid", "sequence": "additional" }, { "affiliation": [], "family": "Ansari", "given": "Nastaran", "sequence": "additional" }, { "affiliation": [], "family": "Mahmoudvand", "given": "Shahab", "sequence": "additional" }, { "affiliation": [], "family": "Mamani", "given": "Mojgan", "sequence": "additional" }, { "affiliation": [], "family": "Abdoli", "given": "Elham", "sequence": "additional" }, { "affiliation": [], "family": "Amini", "given": "Razieh", "sequence": "additional" }, { "affiliation": [], "family": "Kalvandi", "given": "Gholamreza", "sequence": "additional" } ], "container-title": "AMB Express", "container-title-short": "AMB Expr", "content-domain": { "crossmark-restriction": false, "domain": [ "link.springer.com" ] }, "created": { "date-parts": [ [ 2024, 3, 24 ] ], "date-time": "2024-03-24T13:01:33Z", "timestamp": 1711285293000 }, "deposited": { "date-parts": [ [ 2024, 3, 24 ] ], "date-time": "2024-03-24T13:01:43Z", "timestamp": 1711285303000 }, "indexed": { "date-parts": [ [ 2024, 3, 24 ] ], "date-time": "2024-03-24T13:44:34Z", "timestamp": 1711287874643 }, "is-referenced-by-count": 0, "issue": "1", "issued": { "date-parts": [ [ 2024, 3, 24 ] ] }, "journal-issue": { "issue": "1", "published-online": { "date-parts": [ [ 2024, 12 ] ] } }, "language": "en", "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2024, 3, 24 ] ], "date-time": "2024-03-24T00:00:00Z", "timestamp": 1711238400000 } }, { "URL": "https://creativecommons.org/licenses/by/4.0", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2024, 3, 24 ] ], "date-time": "2024-03-24T00:00:00Z", "timestamp": 1711238400000 } } ], "link": [ { "URL": "https://link.springer.com/content/pdf/10.1186/s13568-024-01690-8.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/article/10.1186/s13568-024-01690-8/fulltext.html", "content-type": "text/html", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/content/pdf/10.1186/s13568-024-01690-8.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "297", "original-title": [], "prefix": "10.1186", "published": { "date-parts": [ [ 2024, 3, 24 ] ] }, "published-online": { "date-parts": [ [ 2024, 3, 24 ] ] }, "publisher": "Springer Science and Business Media LLC", "reference": [ { "DOI": "10.1007/s11515-011-1123-9", "author": "AU Ahmed", "doi-asserted-by": "publisher", "first-page": "274", "issue": "4", "journal-title": "Front Biol", "key": "1690_CR1", "unstructured": "Ahmed AU (2011) An overview of inflammation: mechanism and consequences. 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