Clinical study of artesunate in the treatment of coronavirus disease 2019

Lin et al., China Critical Care Medicine, doi:10.3760/cma.j.cn121430-20200312-00412, Apr 2020

Artemisinin

45th treatment shown to reduce risk in November 2022, now with p = 0.0066 from 3 studies, recognized in 13 countries.

Lower risk for recovery.

No treatment is 100% effective. Protocols combine treatments.

6,200+ studies for 200+ treatments. c19early.org

Download Meta Analysis

Prospective study of 43 hospitalized COVID-19 patients in China showing faster symptom improvement and shorter hospitalization with artesunate. Artesunate 60 mg twice daily for 10 days.

Standard of Care (SOC) for COVID-19 in the study country, China, is average with moderate efficacy for approved treatments1.

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recovery time, 31.2% lower, relative time 0.69, p = 0.02, treatment mean 3.33 (±1.91) n=18, control mean 4.84 (±2.19) n=25.

recovery time, 27.9% lower, relative time 0.72, p = 0.04, treatment mean 5.39 (±2.36) n=18, control mean 7.48 (±3.78) n=25, lung lesion absorption start.

recovery time, 17.2% lower, relative time 0.83, p = 0.03, treatment mean 14.11 (±4.16) n=18, control mean 17.04 (±4.42) n=25, lung lesion absorption greater than 70%.

hospitalization time, 8.2% lower, relative time 0.92, p = 0.22, treatment mean 16.56 (±3.71) n=18, control mean 18.04 (±3.97) n=25.

time to viral-, 29.3% lower, relative time 0.71, p = 0.05, treatment mean 4.72 (±2.16) n=18, control mean 6.68 (±3.76) n=25.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

1. c19early.org, c19early.org/soc/china.html.

Lin et al., 28 Apr 2020, retrospective, China, peer-reviewed, 9 authors.

，有很好的应用前景。【关键词】青蒿琥酯；新型冠状病毒肺炎；治疗

Lin Yanrong, Wu Fengyao, Xie Zhouhua, Song Xiaoling, Zhu Qingdong, Wei Jing, Tan Shiji, Liang Lianshao, Beibei Gong

doi:10.3760/cma.j.cn121430-20200312-00412

。治疗后青蒿琥酯联合治疗组症状明显改善时间(d： 3.33±1.91 比 4.84±2.19) 、 2019-nCoV 核酸检测转阴时间(d： 4.72±2.16 比 6.68±3.76) 、肺部病灶开始吸收时间(d ： 5.39±2.36 比 7.48±3.78) 、病灶吸收＞70% 时间(d ： 14.11±4.16 比 17.04±4.42) 以及住院时间(d ： 16.56±3.71 比 18

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Late treatment
is less effective