Efficacy and Safety of Lopinavir/Ritonavir or Arbidol in Adult Patients with Mild/Moderate COVID-19: An Exploratory Randomized Controlled Trial
Yueping Li, Zhiwei Xie, Weiyin Lin, Weiping Cai, Chunyan Wen, Yujuan Guan, Xiaoneng Mo, Jian Wang, Yaping Wang, Ping Peng, Xudan Chen, Wenxin Hong, Guangming Xiao, Jinxin Liu, Lieguang Zhang, Fengyu Hu, Feng Li, Fuchun Zhang, Xilong Deng, Linghua Li
Med, doi:10.1016/j.medj.2020.04.001
Effective therapies against COVID-19 are urgently needed Lopinavir/ritonavir and arbidol were tested in
AUTHOR CONTRIBUTIONS L.L., X.D., and Y.L. conceived the study and designed the protocol. W.C. and F.Z. provided oversight. C.W. contributed to statistical analysis and interpretation of data. L.L. and W.L. drafted the manuscript. F.L. and F.H. conducted nuclear acid RT-PCR. Z.X. and Y.G. reviewed the data independently. J.L. and L.Z. reviewed all radiologic images independently. X.M., J.W., Y.W., P.P., X.C., W.H., and G.X. conducted the study and collected data.
DECLARATION OF INTERESTS The authors declare no competing interests.
STAR + METHODS
KEY RESOURCE TABLE LEAD CONTACT Further information and requests for resources and reagents should be directed to and will be fulfilled by the Lead Contact, Linghua Li (llheliza@126.com).
Data and Code Availability This study did not generate new unique reagents and did not generate new datasets.
EXPERIMENTAL MODEL AND SUBJECT DETAILS
Procedures A standardized protocol was developed for collecting clinical data for all participants. The following data were collected: 1) important dates, including fever onset, admission, progression to severe clinical status, positive-to-negative conversion of SARS-CoV-2 nucleic acid, improvement of chest computed tomography [CT] scan, discharge, or death; 2) presence of predefined comorbidities (hypertension, diabetes mellitus, etc.); 3) daily observation of clinical parameters (temperature, pulse, respiratory rate, oxygen saturation, Inhaled oxygen concentration if needed); 4) The..
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