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0 0.5 1 1.5 2+ Mortality 21% Improvement Relative Risk Case -18% Antiandrogens for COVID-19  Kwon et al.  Prophylaxis Is prophylaxis with antiandrogens beneficial for COVID-19? Retrospective 5,211 patients in the USA More cases with antiandrogens (not stat. sig., p=0.54) Kwon et al., Annals of Oncology, January 2021 Favors various Favors control

Androgen-deprivation therapy and SARS-CoV-2 in men with prostate cancer: findings from the University of California Health System registry

Kwon et al., Annals of Oncology, doi:10.1016/j.annonc.2021.01.067
Jan 2021  
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5th treatment shown to reduce risk in August 2020
*, now known with p = 0.000000056 from 49 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Retrospective 5,211 prostate cancer patients, 799 on ADT, showing no significant differences in COVID-19 outcomes with treatment.
risk of death, 21.1% lower, RR 0.79, p = 1.00, treatment 1 of 799 (0.1%), control 7 of 4,412 (0.2%), NNT 2985.
risk of case, 17.6% higher, RR 1.18, p = 0.54, treatment 18 of 799 (2.3%), control 79 of 4,412 (1.8%), adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kwon et al., 29 Jan 2021, retrospective, USA, peer-reviewed, 7 authors.
This PaperAntiandrogensAll
Effectiveness of famotidine on the risk of poor prognosis in patients with COVID-19: A nationwide cohort study in Korea
BSE Rosie Kwon, Seung Hyung Jun Kim, MD, PhD 4∥ Seung Won Lee, MD, PhD Ai Koyanagi, MD, PhD Jae Il Shin, MD, PhD Tae-Jin Song, Dong Keon Yon, PhD Lee Smith
Heliyon, doi:10.1016/j.heliyon.2023.e16171
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Author contribution Statement Rosie Kwon, Hyung Jun Kim,Seung Won Lee,: Performed the experiments; Analyzed and interpreted the data; Wrote the paper. Lee Smith, Ai Koyanagi: Contributed reagents, materials, analysis tools or data. Jae Il Shin, Tae-Jin Song, Dong Keon Yon: Conceived and designed the experiments; Analyzed and interpreted the data; Contributed reagents, materials, analysis tools or data; Wrote the paper. Conflicts of interest The authors declare no conflicts of interest. Additional information No additional information is available for this paper. ☒ The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ☐ The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: J o u r n a l P r e -p r o o f
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