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0 0.5 1 1.5 2+ Mortality 11% Improvement Relative Risk Ventilation 12% ICU admission 10% Hospitalization time 17% Recovery time 10% c19early.org/fm Pahwani et al. Famotidine for COVID-19 RCT LATE TREATMENT Is late treatment with famotidine beneficial for COVID-19? RCT 178 patients in Pakistan (December 2020 - September 2021) Shorter hospitalization (p<0.0001) and faster recovery (p=0.0011) Pahwani et al., Cureus, doi:10.7759/cureus.22404 Favors famotidine Favors control
Efficacy of Oral Famotidine in Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2
Pahwani et al., Cureus, doi:10.7759/cureus.22404
Pahwani et al., Efficacy of Oral Famotidine in Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2, Cureus, doi:10.7759/cureus.22404
Feb 2022   Source   PDF  
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RCT with 89 famotidine and 89 control patients in Pakistan, showing faster recovery but no significant difference in mortality. 40mg oral famotidine daily.
risk of death, 11.1% lower, RR 0.89, p = 1.00, treatment 8 of 89 (9.0%), control 9 of 89 (10.1%), NNT 89.
risk of mechanical ventilation, 12.5% lower, RR 0.88, p = 0.73, treatment 21 of 89 (23.6%), control 24 of 89 (27.0%), NNT 30.
risk of ICU admission, 10.0% lower, RR 0.90, p = 0.86, treatment 18 of 89 (20.2%), control 20 of 89 (22.5%), NNT 44.
hospitalization time, 16.5% lower, relative time 0.83, p < 0.001, treatment mean 8.6 (±1.6) n=89, control mean 10.3 (±2.2) n=89.
recovery time, 9.6% lower, relative time 0.90, p = 0.001, treatment mean 8.5 (±1.7) n=89, control mean 9.4 (±1.9) n=89.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pahwani et al., 20 Feb 2022, Randomized Controlled Trial, Pakistan, peer-reviewed, mean age 52.0, 8 authors, study period December 2020 - September 2021.
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Abstract: Open Access Original Article DOI: 10.7759/cureus.22404 Efficacy of Oral Famotidine in Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 Review began 01/27/2022 Review ended 02/17/2022 Suraksha Pahwani 1 , Mahesh Kumar 1 , FNU Aperna 1 , Mehak Gul 1 , Darshan Lal 2 , FNU Rakesh 2 , Muhammad Raffey Shabbir 3 , Amber Rizwan 4 Published 02/20/2022 © Copyright 2022 Pahwani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CCBY 4.0., which permits unrestricted use, 1. Internal Medicine, Jinnah Sindh Medical University, Karachi, PAK 2. Internal Medicine, Ghulam Muhammad Mahar Medical College, Sukkur, PAK 3. Internal Medicine, Allama Iqbal Medical College, Lahore, PAK 4. Family Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK distribution, and reproduction in any medium, provided the original author and source are credited. Corresponding author: Amber Rizwan, amber_aljazeera109@hotmail.com Abstract
Late treatment
is less effective
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