Efficacy of Oral Famotidine in Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2
Pahwani et al.
, Efficacy of Oral Famotidine in Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2
, Cureus, doi:10.7759/cureus.22404
RCT with 89 famotidine and 89 control patients in Pakistan, showing faster recovery but no significant difference in mortality. 40mg oral famotidine daily.
risk of death, 11.1% lower, RR 0.89, p = 1.00, treatment 8 of 89 (9.0%), control 9 of 89 (10.1%), NNT 89.
risk of mechanical ventilation, 12.5% lower, RR 0.88, p = 0.73, treatment 21 of 89 (23.6%), control 24 of 89 (27.0%), NNT 30.
risk of ICU admission, 10.0% lower, RR 0.90, p = 0.86, treatment 18 of 89 (20.2%), control 20 of 89 (22.5%), NNT 44.
hospitalization time, 16.5% lower, relative time 0.83, p < 0.001, treatment mean 8.6 (±1.6) n=89, control mean 10.3 (±2.2) n=89.
recovery time, 9.6% lower, relative time 0.90, p = 0.001, treatment mean 8.5 (±1.7) n=89, control mean 9.4 (±1.9) n=89.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pahwani et al., 20 Feb 2022, Randomized Controlled Trial, Pakistan, peer-reviewed, mean age 52.0, 8 authors, study period December 2020 - September 2021.
Abstract: Open Access Original
Eﬃcacy of Oral Famotidine in Patients
Hospitalized With Severe Acute Respiratory
Syndrome Coronavirus 2
Review began 01/27/2022
Review ended 02/17/2022
Suraksha Pahwani 1 , Mahesh Kumar 1 , FNU Aperna 1 , Mehak Gul 1 , Darshan Lal 2 , FNU Rakesh 2 ,
Muhammad Raﬀey Shabbir 3 , Amber Rizwan 4
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Pahwani et al. This is an open access
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1. Internal Medicine, Jinnah Sindh Medical University, Karachi, PAK 2. Internal Medicine, Ghulam Muhammad Mahar
Medical College, Sukkur, PAK 3. Internal Medicine, Allama Iqbal Medical College, Lahore, PAK 4. Family Medicine,
Jinnah Postgraduate Medical Centre, Karachi, PAK
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Corresponding author: Amber Rizwan, email@example.com
is less effective
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