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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 11% Improvement Relative Risk Ventilation 12% ICU admission 10% Hospitalization time 17% Recovery time 10% Famotidine  Pahwani et al.  LATE TREATMENT  RCT Is late treatment with famotidine beneficial for COVID-19? RCT 178 patients in Pakistan (December 2020 - September 2021) Shorter hospitalization (p<0.0001) and faster recovery (p=0.0011) Pahwani et al., Cureus, February 2022 Favors famotidine Favors control

Efficacy of Oral Famotidine in Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2

Pahwani et al., Cureus, doi:10.7759/cureus.22404
Feb 2022  
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Famotidine for COVID-19
26th treatment shown to reduce risk in October 2021
*, now known with p = 0.00026 from 30 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
RCT with 89 famotidine and 89 control patients in Pakistan, showing faster recovery but no significant difference in mortality. 40mg oral famotidine daily.
risk of death, 11.1% lower, RR 0.89, p = 1.00, treatment 8 of 89 (9.0%), control 9 of 89 (10.1%), NNT 89.
risk of mechanical ventilation, 12.5% lower, RR 0.88, p = 0.73, treatment 21 of 89 (23.6%), control 24 of 89 (27.0%), NNT 30.
risk of ICU admission, 10.0% lower, RR 0.90, p = 0.86, treatment 18 of 89 (20.2%), control 20 of 89 (22.5%), NNT 44.
hospitalization time, 16.5% lower, relative time 0.83, p < 0.001, treatment mean 8.6 (±1.6) n=89, control mean 10.3 (±2.2) n=89.
recovery time, 9.6% lower, relative time 0.90, p = 0.001, treatment mean 8.5 (±1.7) n=89, control mean 9.4 (±1.9) n=89.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pahwani et al., 20 Feb 2022, Randomized Controlled Trial, Pakistan, peer-reviewed, mean age 52.0, 8 authors, study period December 2020 - September 2021.
This PaperFamotidineAll
Efficacy of Oral Famotidine in Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2
Suraksha Pahwani, Mahesh Jadwani, Aperna Dhanwani, Mehak Gul, Darshan Lal, Fnu Rakesh, Raffey Shabbir, Amber Rizwan
Cureus, doi:10.7759/cureus.22404
Introduction The clinical benefit of famotidine has been observed in the management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, its use in the management of SARS-CoV-2 is intriguing and not well established yet. In this study, we aimed to determine the role of famotidine as adjuvant therapy in improving the outcome of patients hospitalized with coronavirus disease-2019 . Methods This two-arm open-label randomized interventional study was conducted in the COVID-19 unit of a tertiary care hospital in Pakistan from December 2020 to September 2021. Patients between the ages of 18 to 65 years, hospitalized with COVID-19 infection, were enrolled in the study. Participants were randomized into two groups. The intervention group received 40 mg oral famotidine daily in addition to the standard care and the control group received standard care as per national guidelines for the treatment of COVID-19 in Pakistan. Results Patients admitted with COVID-19 who received famotidine took comparatively fewer days to become symptom-free (8.5 ± 1.7 vs. 9.4 ± 1.9 days, p-value: <0.001) and spent fewer days in hospital (8.6 ± 1.6 vs. 10.3 ± 2.2 days; p-value: <0.0001). However, the overall difference in the need for mechanical ventilation and mortality between the interventional arm and placebo was not significant. Conclusion In this study, adding famotidine to standard treatment of COVID-19 was associated with faster clinical recovery and shorter stay in the hospital. However, there was no difference in the need for mechanical ventilation, need for intensive care unit, and overall mortality. Further large-scale studies are needed to understand the role of famotidine in COVID-19 and its mechanism of action in patients with COVID-19.
Conclusions In this study, adding famotidine to standard treatment of COVID-19 was associated with faster clinical recovery and shorter hospital stay. However, there was no difference in the need for mechanical ventilation, the need for ICU, and overall mortality. Further large-scale studies are needed to understand the role of famotidine in COVID-19 and its possible mechanism of action in patients with COVID-19. Additional Information Disclosures Human subjects: Consent was obtained or waived by all participants in this study. Jinnah Sindh Medical University Ethics Committee issued approval JSMU/IRB/2020/12. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
Ai, Yang, Hou, Correlation of chest CT and RT-PCR testing for coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases, Radiology, doi:10.1148/radiol.2020200642
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Late treatment
is less effective
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