Pahwani: Efficacy of Oral Famotidine in Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2

Efficacy of Oral Famotidine in Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2

Pahwani et al., Cureus, doi:10.7759/cureus.22404

Pahwani et al., Efficacy of Oral Famotidine in Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2, Cureus, doi:10.7759/cureus.22404

Feb 2022 Source PDF

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RCT with 89 famotidine and 89 control patients in Pakistan, showing faster recovery but no significant difference in mortality. 40mg oral famotidine daily.

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risk of death, 11.1% lower, RR 0.89, p = 1.00, treatment 8 of 89 (9.0%), control 9 of 89 (10.1%), NNT 89.

risk of mechanical ventilation, 12.5% lower, RR 0.88, p = 0.73, treatment 21 of 89 (23.6%), control 24 of 89 (27.0%), NNT 30.

risk of ICU admission, 10.0% lower, RR 0.90, p = 0.86, treatment 18 of 89 (20.2%), control 20 of 89 (22.5%), NNT 44.

hospitalization time, 16.5% lower, relative time 0.83, p < 0.001, treatment mean 8.6 (±1.6) n=89, control mean 10.3 (±2.2) n=89.

recovery time, 9.6% lower, relative time 0.90, p = 0.001, treatment mean 8.5 (±1.7) n=89, control mean 9.4 (±1.9) n=89.

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Pahwani et al., 20 Feb 2022, Randomized Controlled Trial, Pakistan, peer-reviewed, mean age 52.0, 8 authors, study period December 2020 - September 2021.

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Abstract: Open Access Original Article DOI: 10.7759/cureus.22404 Eﬃcacy of Oral Famotidine in Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 Review began 01/27/2022 Review ended 02/17/2022 Suraksha Pahwani 1 , Mahesh Kumar 1 , FNU Aperna 1 , Mehak Gul 1 , Darshan Lal 2 , FNU Rakesh 2 , Muhammad Raﬀey Shabbir 3 , Amber Rizwan 4 Published 02/20/2022 © Copyright 2022 Pahwani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CCBY 4.0., which permits unrestricted use, 1. Internal Medicine, Jinnah Sindh Medical University, Karachi, PAK 2. Internal Medicine, Ghulam Muhammad Mahar Medical College, Sukkur, PAK 3. Internal Medicine, Allama Iqbal Medical College, Lahore, PAK 4. Family Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK distribution, and reproduction in any medium, provided the original author and source are credited. Corresponding author: Amber Rizwan, amber_aljazeera109@hotmail.com Abstract

Late treatment
is less effective

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