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0 0.5 1 1.5 2+ Mortality 61% Improvement Relative Risk Death/intubation 50% Famotidine for COVID-19  Mather et al.  Prophylaxis Is prophylaxis with famotidine beneficial for COVID-19? PSM retrospective 772 patients in the USA Lower mortality (p=0.004) and death/intubation (p=0.003) Mather et al., American J. Gastroenter.., Aug 2020 Favors famotidine Favors control

Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients With COVID-19

Mather et al., American Journal of Gastroenterology, doi:10.14309/ajg.0000000000000832
Aug 2020  
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Famotidine for COVID-19
25th treatment shown to reduce risk in October 2021
*, now known with p = 0.00026 from 30 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
PSM retrospective 878 hospitalized patients in the USA, 83 with existing famotidine use, showing significantly lower mortality with treatment.
risk of death, 61.4% lower, HR 0.39, p = 0.004, treatment 83, control 689, propensity score matching, Cox proportional hazards.
risk of death/intubation, 50.5% lower, HR 0.49, p = 0.003, treatment 83, control 689, propensity score matching, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mather et al., 26 Aug 2020, retrospective, USA, peer-reviewed, 3 authors.
This PaperFamotidineAll
Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients With COVID-19
MS. Jeffrey F Mather, PhD Richard L Seip, MD Raymond G Mckay
American Journal of Gastroenterology, doi:10.14309/ajg.0000000000000832
INTRODUCTION: To compare outcomes in patients hospitalized with coronavirus (COVID-19) receiving famotidine therapy with those not receiving famotidine.
Study Highlights WHAT IS KNOWN? 3 Despite multiple trials that are currently underway to investigate the safety and efficacy of a large number of possible therapeutic agents, no drug to date has been shown to reduce COVID-19 mortality. 3 It has been postulated that famotidine's effect is achieved via its antagonism or inverse agonism of the histamine-2 receptor, inferring that the SARS-CoV-2 infection that results in COVID-19 is at least partially mediated by pathological histamine release. COVID-19 Mather et al.
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Caughey, Raymond, Wolters, Angiotensin II generation by mast cell alpha-and beta-chymases, Biochim Biophys Acta
Eliezer, Hautefort, Hamel, Sudden and complete olfactory loss of function as a possible symptom of COVID-19, JAMA Otolaryngol Head Neck Surg
Ezeamuzie, Philips, Histamine, 2) receptors mediate the inhibitory effect of histamine on human eosinophil degranulation, Br J Pharmacol
Flamand, Plante, Picard, Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: Involvement of the H2 receptor and cAMP, Br J Pharmacol
Freedberg, Conigliaro, Wang, Famotidine use is associated with improved clinical outcomes in hospitalized COVID-19 patients: A propensity score matched retrospective cohort study, Gastroenterology, doi:10.1053/j.gastro.2020.05.053
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Janowitz, Gablenz, Pattinson, Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: A case series, Gut
Kritas, Ronconi, Caraffa, Mast cells contribute to coronavirus-induced inflammation: New anti-inflammatory strategy, J Biol Regul Homeost Agents
Malone, Tisdall, Smith, COVID-19: famotidine, histamine, mast cells, and mechanisms, Preprint Res Sq, doi:10.21203/
Marshall, Portales-Cervantes, Leong, Mast cell responses to viruses and pathogen products, Int J Mol Sci
Metcalfe, Baram, Mekori, Mast cells, Physiol Rev
Mukai, Tsai, Saito, Mast cells as sources of cytokines, chemokines, and growth factors, Immunol Rev
Rabier, Damon, Chanez, Inhibition by histamine of plateletactivating-factor-induced neutrophil chemotaxis in bronchial asthma, Int Arch Allergy Appl Immunol
Theoharides, Alysandratos, Angelidou, Mast cells and inflammation, Biochim Biophys Acta
Tian, Hu, Niu, Pulmonary pathology of early-phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer, J Thorac Oncol
Wadee, Anderson, Sher, In vitro effects of histamine on migration, Int Arch Allergy Appl Immunol
Wu, Liu, Yang, Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharm Sin B
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