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0 0.5 1 1.5 2+ Mortality 61% Improvement Relative Risk Death/intubation 50% Mather et al. Famotidine for COVID-19 Prophylaxis Is prophylaxis with famotidine beneficial for COVID-19? PSM retrospective 772 patients in the USA Lower mortality (p=0.004) and death/intubation (p=0.003) Mather et al., American J. Gastroenterology, doi:10.14309/ajg.0000000000000832 Favors famotidine Favors control

Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients With COVID-19

Mather et al., American Journal of Gastroenterology, doi:10.14309/ajg.0000000000000832
Mather et al., Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients With COVID-19, American Journal of Gastroenterology, doi:10.14309/ajg.0000000000000832
Aug 2020   Source   PDF  
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PSM retrospective 878 hospitalized patients in the USA, 83 with existing famotidine use, showing significantly lower mortality with treatment.
risk of death, 61.4% lower, HR 0.39, p = 0.004, treatment 83, control 689, propensity score matching, Cox proportional hazards.
risk of death/intubation, 50.5% lower, HR 0.49, p = 0.003, treatment 83, control 689, propensity score matching, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mather et al., 26 Aug 2020, retrospective, USA, peer-reviewed, 3 authors.
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This PaperFamotidineAll
Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients With COVID-19
MS. Jeffrey F Mather, PhD Richard L Seip, MD Raymond G Mckay
American Journal of Gastroenterology, doi:10.14309/ajg.0000000000000832
INTRODUCTION: To compare outcomes in patients hospitalized with coronavirus (COVID-19) receiving famotidine therapy with those not receiving famotidine.
Study Highlights WHAT IS KNOWN? 3 Despite multiple trials that are currently underway to investigate the safety and efficacy of a large number of possible therapeutic agents, no drug to date has been shown to reduce COVID-19 mortality. 3 It has been postulated that famotidine's effect is achieved via its antagonism or inverse agonism of the histamine-2 receptor, inferring that the SARS-CoV-2 infection that results in COVID-19 is at least partially mediated by pathological histamine release. COVID-19 Mather et al.
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