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Famotidine Use Is Associated With Improved Clinical Outcomes in Hospitalized COVID-19 Patients: A Propensity Score Matched Retrospective Cohort Study

Freedberg et al., Gastroenterology, doi:10.1053/j.gastro.2020.05.053
May 2020  
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Death/intubation 57% Improvement Relative Risk Famotidine for COVID-19  Freedberg et al.  Prophylaxis Is prophylaxis with famotidine beneficial for COVID-19? PSM retrospective 1,620 patients in the USA Lower death/intubation with famotidine (p=0.019) c19early.org Freedberg et al., Gastroenterology, May 2020 Favorsfamotidine Favorscontrol 0 0.5 1 1.5 2+
Famotidine for COVID-19
26th treatment shown to reduce risk in October 2021, now with p = 0.00028 from 30 studies, recognized in 2 countries.
No treatment is 100% effective. Protocols combine treatments.
5,300+ studies for 116 treatments. c19early.org
PSM retrospective 1,620 hospitalized patients in the USA, 84 with existing famotidine use, showing lower risk of combined death/intubation with treatment.
Standard of Care (SOC): SOC for COVID-19 in the study country, the USA, is very poor with very low average efficacy for approved treatments1. Only expensive, high-profit treatments were approved. Low-cost treatments were excluded, reducing the probability of treatment—especially early—due to access and cost barriers, and eliminating complementary and synergistic benefits seen with many low-cost treatments.
Study covers proton pump inhibitors and famotidine.
risk of death/intubation, 57.0% lower, HR 0.43, p = 0.02, treatment 8 of 84 (9.5%), control 332 of 1,536 (21.6%), NNT 8.3, adjusted per study, propensity score matching, multivariable, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Freedberg et al., 21 May 2020, retrospective, propensity score matching, USA, peer-reviewed, 15 authors.
This PaperFamotidineAll
Famotidine Use Is Associated With Improved Clinical Outcomes in Hospitalized COVID-19 Patients: A Propensity Score Matched Retrospective Cohort Study
MD, MS Daniel E Freedberg, Joseph Conigliaro, Timothy C Wang, Kevin J Tracey, Michael V Callahan, MD, MS Julian A Abrams, Magdalena E Sobieszczyk, David D Markowitz, Aakriti Gupta, Max R O’donnell, Jianhua Li, David A Tuveson, Zhezhen Jin, William C Turner, Donald W Landry
Gastroenterology, doi:10.1053/j.gastro.2020.05.053
See Covering the Cover synopsis on page 803.
Supplementary Material Note: To access the supplementary material accompanying this article, visit the online version of Gastroenterology at www.gastrojournal.org, and at https://doi.org/10.1053/ j.gastro.2020.05.053.
References
Anand, Ziebuhr, Wadhwani, None, Science
Bourinbaiar, Fruhstorfer, None, Life Sci
Chen, Deng, Churchill, None, Cell Stem Cell
Gottschlich, Delegge, Guenter, American Society for Parenteral and Enteral Nutrition
Li, Zhang, Liu, Gu, None, FASEB J
Wu, Liu, Yang, None, Acta Pharm Sin B
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