The association of remdesivir and in-hospital outcomes for COVID-19 patients treated with steroids

{ 'indexed': {'date-parts': [[2024, 3, 22]], 'date-time': '2024-03-22T16:18:31Z', 'timestamp': 1711124311613}, 'reference-count': 28, 'publisher': 'Oxford University Press (OUP)', 'issue': '10', 'license': [ { 'start': { 'date-parts': [[2021, 8, 9]], 'date-time': '2021-08-09T00:00:00Z', 'timestamp': 1628467200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2021, 9, 15]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Remdesivir ' 'has been shown to decrease SARS-CoV-2 viral loads and the duration of COVID-19 symptoms. ' 'However, current evidence regarding the association between remdesivir and in-hospital ' 'mortality for patients with COVID-19 steroid treatments is limited. We aimed to investigate ' 'whether remdesivir reduces in-hospital mortality among patients with COVID-19 treated with ' 'steroids.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In this ' 'retrospective multicentre study, we reviewed the medical records of 3372 patients discharged ' 'between 1 March 2020 and 30 March 2021, with laboratory confirmed COVID-19 in the Mount Sinai ' 'Health System and treated with steroids. We evaluated the effect of remdesivir on the ' 'outcomes using propensity score analyses. Subgroup analyses were conducted by stratification ' 'of patients by endotracheal intubation and COVID-19 antibody status. Acute kidney injury ' '(AKI) was defined as an absolute serum creatinine increase of 0.3\u2009mg/dL or a relative ' 'increase of 50%.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of the ' '3372 eligible patients, 1336 (39.6%) received remdesivir. After 1:1 propensity score matching ' '(N\u2009=\u2009999 pairs), in-hospital mortality was similar between those with and without ' 'remdesivir (21.4% versus 21.6%, respectively, P\u2009=\u20090.96). Remdesivir was not ' 'significantly associated with in-hospital mortality regardless of endotracheal intubation or ' 'COVID-19 antibody status. However, there was a signal that remdesivir was associated with a ' 'reduced risk of AKI in the propensity matched analysis (17.5% versus 23.4%, respectively, ' 'P\u2009=\u2009' '0.001).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Remdesivir ' 'was not associated with reduced risk of in-hospital mortality in patients with COVID-19 ' 'treated with steroids but potentially associated with decreased risk of AKI. These findings ' 'should be confirmed in prospective studies focusing on COVID-19 patients treated with ' 'steroids.</jats:p></jats:sec>', 'DOI': '10.1093/jac/dkab256', 'type': 'journal-article', 'created': {'date-parts': [[2021, 7, 2]], 'date-time': '2021-07-02T11:24:37Z', 'timestamp': 1625225077000}, 'page': '2690-2696', 'source': 'Crossref', 'is-referenced-by-count': 13, 'title': 'The association of remdesivir and in-hospital outcomes for COVID-19 patients treated with ' 'steroids', 'prefix': '10.1093', 'volume': '76', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-2487-8366', 'authenticated-orcid': False, 'given': 'Toshiki', 'family': 'Kuno', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Medicine, Icahn School of Medicine at Mount Sinai, ' 'Mount Sinai Beth Israel, New York, NY, USA'}]}, { 'given': 'Yoshihisa', 'family': 'Miyamoto', 'sequence': 'additional', 'affiliation': [ { 'name': 'Division of Nephrology and Endocrinology, The University of ' 'Tokyo, Tokyo, Japan'}]}, { 'given': 'Masao', 'family': 'Iwagami', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Health Services Research, University of Tsukuba, ' 'Tsukuba, Japan'}]}, { 'given': 'Miho', 'family': 'Ishimaru', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Health Services Research, University of Tsukuba, ' 'Tsukuba, Japan'}]}, { 'given': 'Mai', 'family': 'Takahashi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine, Icahn School of Medicine at Mount Sinai, ' 'Mount Sinai Beth Israel, New York, NY, USA'}]}, { 'given': 'Natalia N', 'family': 'Egorova', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Population Health Science and Policy, Icahn School ' 'of Medicine at Mount Sinai, New York, NY, USA'}]}], 'member': '286', 'published-online': {'date-parts': [[2021, 8, 9]]}, 'reference': [ { 'key': '2021091708523184900_dkab256-B1', 'doi-asserted-by': 'crossref', 'first-page': '727', 'DOI': 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