Antiviral drug treatment profiles and clinical outcomes of COVID-19 patients at public hospitals in Erbil city

{ 'indexed': {'date-parts': [[2024, 9, 10]], 'date-time': '2024-09-10T00:24:05Z', 'timestamp': 1725927845673}, 'reference-count': 0, 'publisher': 'Kurdistan Higher Council of Medical Specialties', 'issue': '3', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2024, 9, 9]]}, 'abstract': '<jats:p>ackground &amp; objectives: The World Health Organization has identified COVID-19 as ' 'a rapidly spreading global disease. Some antiviral drugs have shown promising efficacy in ' 'treating COVID-19. This study aims to identify the effects of antiviral drugs and compare ' 'them with other therapies in COVID-19 patients, while reviewing the clinical outcomes of ' 'these treatments. Methods: This observational retrospective case study included 451 COVID-19 ' 'patients, comprising 57.0% males and 43% females, conducted in Rizgari, Erbil, at Central ' 'Emergency, Rozhawa Emergency, and Emirate Hospitals over one year from December 2020 to ' 'December 2021. COVID-19 cases were confirmed using reverse transcriptase polymerase-chain ' 'reaction (RT-PCR) assays, and treatment followed the WHO guidelines, involving antivirals ' '(Remdesivir, Favipiravir), broad-spectrum antibiotics (levofloxacin, azithromycin, ' 'ceftriaxone, meropenem, imipenem), and supportive treatment with Becozym (Vitamins B1 + B2 + ' 'B3 + B5 + B6). Data were recorded in the statistical department of the hospitals. Results: ' 'The total age range of the 451 patients was 95 (18-113) with a mean ± SD of 59.408 ± 18.26 ' 'years. The death rate was 22.39%. A majority of the survival patients were in the young age ' 'group (95.1%), while the death rate was higher in the old age group (more than 75 years). The ' 'death rate of patients treated with antiviral drug Remdesivir was 15.30%, while it was ' '37.93%, 73.45%, 15.25%, and 14.15% in patients on levofloxacin, ceftriaxone, meropenem, and ' 'Becozyme, espectively. Logistic regression analysis did not show any role of treatments in ' 'decreasing mortality. Conclusions: Significant differences were observed in clinical ' 'outcomes; the majority of surviving patients were in the young age group, while older ' 'COVID-19 patients had worse illnesses and treatment outcomes. Diabetes and hypertension were ' 'significant predictors of COVID-19 mortality. Although Remdesivir treatment showed a ' 'statistically significant association between survival and death cohorts, it was not ' 'considered a predictor variable for survival. Antibiotics and supplement drugs like Becozyme ' 'were also not considered predictors of survival for COVID-19 patients.</jats:p>', 'DOI': '10.56056/amj.2024.273', 'type': 'journal-article', 'created': {'date-parts': [[2024, 9, 9]], 'date-time': '2024-09-09T08:15:43Z', 'timestamp': 1725869743000}, 'page': '17-25', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Antiviral drug treatment profiles and clinical outcomes of COVID-19 patients at public hospitals ' 'in Erbil city.', 'prefix': '10.56056', 'volume': '9', 'author': [ { 'name': 'Trainee at Infection disease control department of public health, Kurdistan higher ' 'council for medical specialties, Rizghary Hospital, Erbil city-Kurdistan ' 'region/Iraq', 'sequence': 'first', 'affiliation': []}, {'given': 'Ronia Shawksat', 'family': 'Kawther', 'sequence': 'first', 'affiliation': []}, {'given': 'Sherzad Ali', 'family': 'Ismael', 'sequence': 'additional', 'affiliation': []}, { 'name': 'Assistant Professor in Community Medicine,Chairman of Public Health council, ' 'Kurdistan higher council for medical specialties, Erbil City-Kurdistan region/Iraq', 'sequence': 'additional', 'affiliation': []}, {'given': 'Maaroof Tahseen', 'family': 'Hassan', 'sequence': 'additional', 'affiliation': []}, { 'name': 'Assistant Professor in Community Medicine. Program Director of Infection Disease ' 'Control Department, Deputy President of Kurdistan higher council for medical ' 'specialties, Erbil city-Kurdistan region/Iraq.', 'sequence': 'additional', 'affiliation': []}], 'member': '35163', 'published-online': {'date-parts': [[2024, 9, 9]]}, 'container-title': 'Advanced medical journal', 'original-title': [], 'deposited': { 'date-parts': [[2024, 9, 9]], 'date-time': '2024-09-09T08:15:46Z', 'timestamp': 1725869746000}, 'score': 1, 'resource': {'primary': {'URL': 'https://amj.khcms.edu.krd/index.php/main/article/view/473'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 9, 9]]}, 'references-count': 0, 'journal-issue': { 'issue': '3', 'published-online': {'date-parts': [[2024, 9, 9]]}, 'published-print': {'date-parts': [[2024, 9, 9]]}}, 'URL': 'http://dx.doi.org/10.56056/amj.2024.273', 'relation': {}, 'ISSN': ['2958-8979', '2957-3580'], 'subject': [], 'container-title-short': 'adv.med.j.', 'published': {'date-parts': [[2024, 9, 9]]}}