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Antiviral drug treatment profiles and clinical outcomes of COVID-19 patients at public hospitals in Erbil city

Kawther et al., Advanced medical journal, doi:10.56056/amj.2024.273
Sep 2024  
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Mortality -9% Improvement Relative Risk Remdesivir  Kawther et al.  LATE TREATMENT Is late treatment with remdesivir beneficial for COVID-19? Retrospective 451 patients in Iraq (December 2020 - December 2021) No significant difference in mortality c19early.org Kawther et al., Advanced medical journal, Sep 2024 Favorsremdesivir Favorscontrol 0 0.5 1 1.5 2+
Retrospective 451 hospitalized COVID-19 patients in Iraq showing no significant difference in mortality with remdesivir treatment.
Gérard, Zhou, Wu, Kamo, Choi show significantly increased risk of acute kidney injury with remdesivir.
risk of death, 8.7% higher, OR 1.09, p = 0.86, treatment 111, control 340, adjusted per study, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kawther et al., 9 Sep 2024, retrospective, Iraq, peer-reviewed, 6 authors, study period December 2020 - December 2021.
This PaperRemdesivirAll
Antiviral drug treatment profiles and clinical outcomes of COVID-19 patients at public hospitals in Erbil city
Ronia Shawksat Kawther
Advanced medical journal, doi:10.56056/amj.2024.273
Background & objectives: The World Health Organization has identified COVID-19 as a rapidly spreading global disease. Some antiviral drugs have shown promising efficacy in treating COVID-19. This study aims to identify the effects of antiviral drugs and compare them with other therapies in COVID-19 patients, while reviewing the clinical outcomes of these treatments. Methods: This observational retrospective case study included 451 COVID-19 patients, comprising 57.0% males and 43% females, conducted in Rizgari, Erbil, at Central Emergency, Rozhawa Emergency, and Emirate Hospitals over one year from December 2020 to December 2021. COVID-19 cases were confirmed using reverse transcriptase polymerase-chain reaction (RT-PCR) assays, and treatment followed the WHO guidelines, involving antivirals (Remdesivir, Favipiravir), broad-spectrum antibiotics (levofloxacin, azithromycin, ceftriaxone, meropenem, imipenem), and supportive treatment with Becozym (Vitamins B1 + B2 + B3 + B5 + B6). Data were recorded in the statistical department of the hospitals. Results: The total age range of the 451 patients was 95 (18-113) with a mean ± SD of 59.408 ± 18.26 years. The death rate was 22.39%. A majority of the survival patients were in the young age group (95.1%), while the death rate was higher in the old age group (more than 75 years). The death rate of patients treated with antiviral drug Remdesivir was 15.30%, while it was 37.93%, 73.45%, 15.25%, and 14.15% in patients on levofloxacin, ceftriaxone, meropenem, and Becozyme, espectively. Logistic regression analysis did not show any role of treatments in decreasing mortality. Conclusions: Significant differences were observed in clinical outcomes; the majority of surviving patients were in the young age group, while older COVID-19 patients had worse illnesses and treatment outcomes. Diabetes and hypertension were significant predictors of COVID-19 mortality. Although Remdesivir treatment showed a statistically significant association between survival and death cohorts, it was not considered a predictor variable for survival. Antibiotics and supplement drugs like Becozyme were also not consid ered predictors of survival for COVID-19 patients.
Conflicts of Interest: None.
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Late treatment
is less effective
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