Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All remdesivir studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchRemdesivirRemdesivir (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

Determinants of Outcome Among Critically Ill Police Personnel With COVID-19: A Retrospective Observational Study From Andhra Pradesh, India

Jamir et al., Cureus, doi:10.7759/cureus.20394
Dec 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality 8% Improvement Relative Risk Remdesivir for COVID-19  Jamir et al.  ICU PATIENTS Is very late treatment with remdesivir beneficial for COVID-19? Retrospective 266 patients in India (June - October 2020) No significant difference in mortality c19early.org Jamir et al., Cureus, December 2021 Favorsremdesivir Favorscontrol 0 0.5 1 1.5 2+
Retrospective 266 COVID-19 ICU patients in India, showing significantly lower mortality with PVP-I oral gargling and topical nasal use, and non-statistically significant higher mortality with ivermectin and lower mortality with remdesivir.
Gérard, Zhou, Wu, Kamo, Choi show significantly increased risk of acute kidney injury with remdesivir.
Remdesivir efficacy disappears with longer followup. Mixed-effects meta-regression of efficacy as a function of followup duration across all remdesivir studies shows decreasing efficacy with longer followup6. This may reflect antiviral efficacy being offset by serious adverse effects of treatment.
Followup duration (days) Efficacy Remdesivir mortality efficacy decreases with longer followup 0 15 30 45 60 75 90 105 -25% 0% 25% 50% c19early.org November 2024 mixed-effects meta-regression slope -0.58 [95% CI -0.92 to -0.24] p=0.00089
Study covers ivermectin, povidone-iodine, and remdesivir.
risk of death, 8.0% lower, HR 0.92, p = 0.77, treatment 60 of 181 (33.1%), control 41 of 85 (48.2%), NNT 6.6, adjusted per study, multivariable, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Jamir et al., 13 Dec 2021, retrospective, India, peer-reviewed, 6 authors, study period June 2020 - October 2020. Contact: limalemj@gmail.com.
This PaperRemdesivirAll
Determinants of Outcome Among Critically Ill Police Personnel With COVID-19: A Retrospective Observational Study From Andhra Pradesh, India
Limalemla Jamir, Mukesh Tripathi, Sumita Shankar, Rakesh Kakkar, Ravishankar Ayyanar, Rajeev Aravindakshan
Cureus, doi:10.7759/cureus.20394
Background and Aims: Police personnel have been key frontline workers throughout the coronavirus disease 2019 pandemic. This study was conducted to assess the correlates and outcomes of critically ill police personnel. Methods: This retrospective observational study analyzed key parameters of hospitalized police personnel who were critically ill with COVID-19 in Andhra Pradesh, India, between June and October 2020. Survival was analyzed for correlation with body mass index, ABO/Rh blood group, co-morbidities, treatment (oxygen therapy, prone positioning, mechanical ventilation, remdesivir, Ivermectin, oral and nasal topical povidoneiodine). We also performed Cox proportional hazard analysis with relevant function plots. Results: The majority of the 266 patients were male (n = 259; 97.4%) and obese (75.2%). The overall mortality of patients was 38% (n = 101). COVID-19 mortality increased significantly with age (p = 0.019) and BMI (p = 0.030) in the bivariate analysis. There was no significant difference between blood group (p = 0.297), comorbidity (p = 0.582) and COVID-19 outcome. Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of the risk factors for COVID-19 mortality were males (HR 4.89, 95% CI: 1.020-23.430) and ventilator therapy (HR 7.5, 95% CI: 4.527-12.296). The protective factors were symptom onset to reverse transcription polymerase chain reaction (RT-PCR) report interval (HR 0.36, 95% CI: 0.158-0.814), prone positioning (HR 0.43, 95% CI: 0.197-0.915), and use of povidone iodine (HR 0.43; 95% CI: 0.273-0.692). Conclusion: COVID-19 mortality among critically ill hospitalized police personnel was reduced by time to diagnostic test result, prone positioning, and povidone-iodine use and increased with male gender and mechanical ventilation.
Additional Information Disclosures Human subjects: Consent was obtained or waived by all participants in this study. All India Institute of Medical Sciences (AIIMS), Mangalagiri, Andhra Pradesh issued approval IEC-AIIMS/Mangalagiri/2020-21/40. The committee after critical review and discussion of the documents approved the Research Study in All India institute Of Medical Sciences, Mangalagiri vide IEC-AIIMS/Mangalagiri/2020-21/40 dated 12.06.2021. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
References
Abumayyaleh, Gil, El-Battrawy, Does there exist an obesity paradox in COVID-19? Insights of the international HOPE-COVID-19-registry, Obes Res Clin Pract, doi:10.1016/j.orcp.2021.02.008?utm_medium=email&utm_source=transaction
Alser, Mokhtari, Naar, Multisystem outcomes and predictors of mortality in critically ill patients with COVID-19: demographics and disease acuity matter more than comorbidities or treatment modalities, J Trauma Acute Care Surg, doi:10.1097/TA.0000000000003085?utm_medium=email&utm_source=transaction
Astua, Michaels, Michaels, Prone during pandemic: development and implementation of a qualitybased protocol for proning severe COVID-19 hypoxic lung failure patients in situationally or historically low resource hospitals, BMC Pulm Med, doi:10.1186/s12890-021-01401-0?utm_medium=email&utm_source=transaction
Bastos, Azambuja, Polanczyk, Clinical characteristics and predictors of mechanical ventilation in patients with COVID-19 hospitalized in Southern Brazil, Rev Bras Ter Intensiva, doi:10.5935/0103-507X.20200082?utm_medium=email&utm_source=transaction
Blasi, A case of COVID-19 infection quickly relieved after nasal instillations and gargles with povidone iodine, Rev Cardiovasc Med, doi:10.31083/j.rcm2202033?utm_medium=email&utm_source=transaction
Bloom, Drake, Docherty, Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK, Lancet Respir Med, doi:10.1016/S2213-2600(21)00013-8?utm_medium=email&utm_source=transaction
Bryant, Lawrie, Dowswell, Fordham, Mitchell et al., Ivermectin for prevention and treatment of COVID-19 infection: a systematic review, meta-analysis, and trial sequential analysis to inform clinical guidelines, Am J Ther, doi:10.1097/MJT.0000000000001402?utm_medium=email&utm_source=transaction
Dey, Majumdar, Saha, Sahu, COVID-19 pandemic lockdown-induced altered sleep/wake circadian rhythm, health complaints and stress among traffic police personnel in India, Chronobiol Int, doi:10.1080/07420528.2020.1831524?utm_medium=email&utm_source=transaction
Du, Lv, Zha, Zhou, Hong, Association of body mass index (BMI) with critical COVID-19 and inhospital mortality: a dose-response meta-analysis, Metabolism, doi:10.1016/j.metabol.2020.154373?utm_medium=email&utm_source=transaction
Elsayed, Hassaballa, Ahmed, Gumaa, Sharkawy et al., Variation in outcome of invasive mechanical ventilation between different countries for patients with severe COVID-19: a systematic review and meta-analysis, PLoS One, doi:10.1371/journal.pone.0252760?utm_medium=email&utm_source=transaction
Franchini, Cruciani, Mengoli, ABO blood group and COVID-19: an updated systematic literature review and meta-analysis, Blood Transfus, doi:10.2450/2021.0049-21?utm_medium=email&utm_source=transaction
Gershengorn, Hu, Chen, Hsieh, Dong et al., The impact of high-flow nasal cannula use on patient mortality and the availability of mechanical ventilators in COVID-19, Ann Am Thorac Soc, doi:10.1513/AnnalsATS.202007-803OC?utm_medium=email&utm_source=transaction
Girardin, Seixas, Cejudo, Osorio, Avirappattu et al., Contribution of pulmonary diseases to COVID-19 mortality in a diverse urban community of New York, Chron Respir Dis, doi:10.1177/1479973120986806?utm_medium=email&utm_source=transaction
Hernández-Vásquez, Azañedo, COVID-19 in Peru: the need to pay attention to the high number of police deaths due to the pandemic, J Public Health (Oxf), doi:10.1093/pubmed/fdaa079?utm_medium=email&utm_source=transaction
Jamir, None, Cureus, doi:10.7759/cureus.203949of9
Kompaniyets, Goodman, Belay, Body mass index and risk for COVID-19-related hospitalization, intensive care unit admission, invasive mechanical ventilation, and death -United States, March, MMWR Morb Mortal Wkly Rep, doi:10.15585/mmwr.mm7010e4?utm_medium=email&utm_source=transaction
Langer, Brioni, Guzzardella, Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients, Crit Care, doi:10.1186/s13054-021-03552-2?utm_medium=email&utm_source=transaction
Latz, Decarlo, Boitano, Blood type and outcomes in patients with COVID-19, Ann Hematol, doi:10.1007/s00277-020-04169-1?utm_medium=email&utm_source=transaction
Mallik, Mukhopadhyay, Kumar, Hypertension, prehypertension and normotension among police personnel in a district of West Bengal, India, J Assoc Physicians India
Pan, Peto, Henao-Restrepo, Repurposed antiviral drugs for Covid-19 -interim WHO Solidarity Trial results, N Engl J Med, doi:10.1056/NEJMoa2023184?utm_medium=email&utm_source=transaction
Ravikumar, Kanagarethinam, Nair, Kar, Are police personnel in Puducherry healthy? Findings from "Partners in Prevention" programme in Puducherry, India, Indian J Occup Environ Med, doi:10.4103/ijoem.IJOEM_105_17?utm_medium=email&utm_source=transaction
Roedl, Jarczak, Thasler, Mechanical ventilation and mortality among 223 critically ill patients with coronavirus disease 2019: a multicentric study in Germany, Aust Crit Care, doi:10.1016/j.aucc.2020.10.009?utm_medium=email&utm_source=transaction
Singh, Singh, Joshi, Misra, Mucormycosis in COVID-19: a systematic review of cases reported worldwide and in India, Diabetes Metab Syndr, doi:10.1016/j.dsx.2021.05.019?utm_medium=email&utm_source=transaction
Swain, Behera, Sahu, Povidone iodine soaked gelfoam for the treatment of recalcitrant otomycosis -our experiences at a tertiary care teaching hospital of eastern India, J Mycol Med, doi:10.1016/j.mycmed.2017.11.006?utm_medium=email&utm_source=transaction
Tovani-Palone, Shamsoddin, Use of mouthwashes in the management of COVID-19 patients in intensive care units: recommendations and current evidence, Einstein, doi:10.31744/einstein_journal/2021CE6419?utm_medium=email&utm_source=transaction
Tramunt, Smati, Coudol, Sex disparities in COVID-19 outcomes of inpatients with diabetes: insights from the CORONADO study, Eur J Endocrinol, doi:10.1530/EJE-21-0068?utm_medium=email&utm_source=transaction
Wang, Chen, Chen, Does asthma increase the mortality of patients with COVID-19?: A systematic review and meta-analysis, Int Arch Allergy Immunol, doi:10.1159/000510953?utm_medium=email&utm_source=transaction
Weizman, Mika, Cellier, Characteristics and impact of cardiovascular comorbidities on coronavirus disease 2019 in women: a multicentre cohort study, Arch Cardiovasc Dis, doi:10.1016/j.acvd.2021.04.002?utm_medium=email&utm_source=transaction
Yang, Zheng, Shi, Who should be prioritized for COVID-19 vaccination in China? A descriptive study, BMC Med, doi:10.1186/s12916-021-01923-8?utm_medium=email&utm_source=transaction
Zirpe, Tiwari, Gurav, Timing of invasive mechanical ventilation and mortality among patients with severe COVID-19-associated acute respiratory distress syndrome, Indian J Crit Care Med, doi:10.5005/jp-journals-10071-23816?utm_medium=email&utm_source=transaction
{ 'indexed': { 'date-parts': [[2021, 12, 14]], 'date-time': '2021-12-14T06:06:24Z', 'timestamp': 1639461984840}, 'reference-count': 30, 'publisher': 'Cureus, Inc.', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'short-container-title': [], 'published-print': {'date-parts': [[2021, 12, 13]]}, 'DOI': '10.7759/cureus.20394', 'type': 'journal-article', 'created': { 'date-parts': [[2021, 12, 13]], 'date-time': '2021-12-13T18:19:52Z', 'timestamp': 1639419592000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': [ 'Determinants of Outcome Among Critically Ill Police Personnel With COVID-19: A Retrospective ' 'Observational Study From Andhra Pradesh, India'], 'prefix': '10.7759', 'author': [ {'given': 'Limalemla', 'family': 'Jamir', 'sequence': 'first', 'affiliation': []}, {'given': 'Mukesh', 'family': 'Tripathi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sumita', 'family': 'Shankar', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rakesh', 'family': 'Kakkar', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ravishankar', 'family': 'Ayyanar', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rajeev', 'family': 'Aravindakshan', 'sequence': 'additional', 'affiliation': []}], 'member': '4492', 'reference': [ { 'key': 'ref1', 'doi-asserted-by': 'publisher', 'DOI': '10.1186/s12916-021-01923-8', 'article-title': 'Who should be prioritized for COVID-19 vaccination in China? A ' 'descriptive study', 'volume': '19', 'author': 'Yang J', 'year': '2021', 'unstructured': 'Yang J, Zheng W, Shi H, et al.. Who should be prioritized for COVID-19 ' 'vaccination in China? A descriptive study. BMC Med. 2021, 19:45. ' '10.1186/s12916-021-01923-8', 'journal-title': 'BMC Med'}, { 'key': 'ref2', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/07420528.2020.1831524', 'article-title': 'COVID-19 pandemic lockdown-induced altered sleep/wake circadian rhythm, ' 'health complaints and stress among traffic police personnel in India', 'volume': '38', 'author': 'Dey A', 'year': '2021', 'unstructured': 'Dey A, Majumdar P, Saha A, Sahu S. COVID-19 pandemic lockdown-induced ' 'altered sleep/wake circadian rhythm, health complaints and stress among ' 'traffic police personnel in India. Chronobiol Int. 2021, 38:140-8. ' '10.1080/07420528.2020.1831524', 'journal-title': 'Chronobiol Int'}, { 'key': 'ref3', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/pubmed/fdaa079', 'article-title': 'COVID-19 in Peru: the need to pay attention to the high number of ' 'police deaths due to the pandemic', 'volume': '42', 'author': 'Hernández-Vásquez A', 'year': '2020', 'unstructured': 'Hernández-Vásquez A, Azañedo D. COVID-19 in Peru: the need to pay ' 'attention to the high number of police deaths due to the pandemic. J ' 'Public Health (Oxf). 2020, 42:640-1. 10.1093/pubmed/fdaa079', 'journal-title': 'J Public Health (Oxf)'}, { 'key': 'ref4', 'doi-asserted-by': 'publisher', 'DOI': '10.1097/TA.0000000000003085', 'article-title': 'Multisystem outcomes and predictors of mortality in critically ill ' 'patients with COVID-19: demographics and disease acuity matter more ' 'than comorbidities or treatment modalities', 'volume': '90', 'author': 'Alser O', 'year': '2021', 'unstructured': 'Alser O, Mokhtari A, Naar L, et al.. Multisystem outcomes and predictors ' 'of mortality in critically ill patients with COVID-19: demographics and ' 'disease acuity matter more than comorbidities or treatment modalities. J ' 'Trauma Acute Care Surg. 2021, 90:880-90. 10.1097/TA.0000000000003085', 'journal-title': 'J Trauma Acute Care Surg'}, { 'key': 'ref5', 'doi-asserted-by': 'publisher', 'DOI': '10.1371/journal.pone.0252760', 'article-title': 'Variation in outcome of invasive mechanical ventilation between ' 'different countries for patients with severe COVID-19: a systematic ' 'review and meta-analysis', 'volume': '16', 'author': 'Elsayed HH', 'year': '2021', 'unstructured': 'Elsayed HH, Hassaballa AS, Ahmed TA, Gumaa M, Sharkawy HY, Moharram AA. ' 'Variation in outcome of invasive mechanical ventilation between ' 'different countries for patients with severe COVID-19: a systematic ' 'review and meta-analysis. PLoS One. 2021, 16:e0252760. ' '10.1371/journal.pone.0252760', 'journal-title': 'PLoS One'}, { 'key': 'ref6', 'unstructured': 'Clinical management protocol. COVID-19. (2020). Accessed: August 10, ' '2021: ' 'https://www.mohfw.gov.in/pdf/ClinicalManagementProtocolforCOVID19dated27062020.pdf.'}, { 'key': 'ref7', 'doi-asserted-by': 'publisher', 'DOI': '10.1530/EJE-21-0068', 'article-title': 'Sex disparities in COVID-19 outcomes of inpatients with diabetes: ' 'insights from the CORONADO study', 'volume': '185', 'author': 'Tramunt B', 'year': '2021', 'unstructured': 'Tramunt B, Smati S, Coudol S, et al.. Sex disparities in COVID-19 ' 'outcomes of inpatients with diabetes: insights from the CORONADO study. ' 'Eur J Endocrinol. 2021, 185:299-311. 10.1530/EJE-21-0068', 'journal-title': 'Eur J Endocrinol'}, { 'key': 'ref8', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.acvd.2021.04.002', 'article-title': 'Characteristics and impact of cardiovascular comorbidities on ' 'coronavirus disease 2019 in women: a multicentre cohort study', 'volume': '114', 'author': 'Weizman O', 'year': '2021', 'unstructured': 'Weizman O, Mika D, Cellier J, et al.. Characteristics and impact of ' 'cardiovascular comorbidities on coronavirus disease 2019 in women: a ' 'multicentre cohort study. Arch Cardiovasc Dis. 2021, 114:394-406. ' '10.1016/j.acvd.2021.04.002', 'journal-title': 'Arch Cardiovasc Dis'}, { 'key': 'ref9', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s00277-020-04169-1', 'article-title': 'Blood type and outcomes in patients with COVID-19', 'volume': '99', 'author': 'Latz CA', 'year': '2020', 'unstructured': 'Latz CA, DeCarlo C, Boitano L, et al.. Blood type and outcomes in ' 'patients with COVID-19. Ann Hematol. 2020, 99:2113-8. ' '10.1007/s00277-020-04169-1', 'journal-title': 'Ann Hematol'}, { 'key': 'ref10', 'doi-asserted-by': 'publisher', 'DOI': '10.2450/2021.0049-21', 'article-title': 'ABO blood group and COVID-19: an updated systematic literature review ' 'and meta-analysis', 'volume': '19', 'author': 'Franchini M', 'year': '2021', 'unstructured': 'Franchini M, Cruciani M, Mengoli C, et al.. ABO blood group and ' 'COVID-19: an updated systematic literature review and meta-analysis. ' 'Blood Transfus. 2021, 19:317-26. 10.2450/2021.0049-21', 'journal-title': 'Blood Transfus'}, { 'key': 'ref11', 'doi-asserted-by': 'publisher', 'DOI': '10.15585/mmwr.mm7010e4', 'article-title': 'Body mass index and risk for COVID-19-related hospitalization, ' 'intensive care unit admission, invasive mechanical ventilation, and ' 'death - United States, March-December 2020', 'volume': '70', 'author': 'Kompaniyets L', 'year': '2021', 'unstructured': 'Kompaniyets L, Goodman AB, Belay B, et al.. Body mass index and risk for ' 'COVID-19-related hospitalization, intensive care unit admission, ' 'invasive mechanical ventilation, and death - United States, ' 'March-December 2020. MMWR Morb Mortal Wkly Rep. 2021, 70:355-61. ' '10.15585/mmwr.mm7010e4', 'journal-title': 'MMWR Morb Mortal Wkly Rep'}, { 'key': 'ref12', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.metabol.2020.154373', 'article-title': 'Association of body mass index (BMI) with critical COVID-19 and ' 'in-hospital mortality: a dose-response meta-analysis', 'volume': '117', 'author': 'Du Y', 'year': '2021', 'unstructured': 'Du Y, Lv Y, Zha W, Zhou N, Hong X. Association of body mass index (BMI) ' 'with critical COVID-19 and in-hospital mortality: a dose-response ' 'meta-analysis. Metabolism. 2021, 117:154373. ' '10.1016/j.metabol.2020.154373', 'journal-title': 'Metabolism'}, { 'key': 'ref13', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.orcp.2021.02.008', 'article-title': 'Does there exist an obesity paradox in COVID-19? Insights of the ' 'international HOPE-COVID-19-registry', 'volume': '15', 'author': 'Abumayyaleh M', 'year': '2021', 'unstructured': 'Abumayyaleh M, Núñez Gil IJ, El-Battrawy I, et al.. Does there exist an ' 'obesity paradox in COVID-19? Insights of the international ' 'HOPE-COVID-19-registry. Obes Res Clin Pract. 2021, 15:275-80. ' '10.1016/j.orcp.2021.02.008', 'journal-title': 'Obes Res Clin Pract'}, { 'key': 'ref14', 'doi-asserted-by': 'publisher', 'DOI': '10.4103/ijoem.IJOEM_105_17', 'article-title': 'Are police personnel in Puducherry healthy? Findings from "Partners in ' 'Prevention" programme in Puducherry, India', 'volume': '21', 'author': 'Ravikumar TS', 'year': '2017', 'unstructured': 'Ravikumar TS, Kanagarethinam R, Nair D, Kar SS. Are police personnel in ' 'Puducherry healthy? Findings from "Partners in Prevention" programme in ' 'Puducherry, India. Indian J Occup Environ Med. 2017, 21:84-8. ' '10.4103/ijoem.IJOEM_105_17', 'journal-title': 'Indian J Occup Environ Med'}, { 'key': 'ref15', 'article-title': 'Hypertension, prehypertension and normotension among police personnel ' 'in a district of West Bengal, India', 'volume': '62', 'author': 'Mallik D', 'year': '2014', 'unstructured': 'Mallik D, Mukhopadhyay DK, Kumar P, et al.. Hypertension, ' 'prehypertension and normotension among police personnel in a district of ' 'West Bengal, India. J Assoc Physicians India. 2014, 62:12-6.', 'journal-title': 'J Assoc Physicians India'}, { 'key': 'ref16', 'doi-asserted-by': 'publisher', 'DOI': '10.1159/000510953', 'article-title': 'Does asthma increase the mortality of patients with COVID-19?: A ' 'systematic review and meta-analysis', 'volume': '182', 'author': 'Wang Y', 'year': '2021', 'unstructured': 'Wang Y, Chen J, Chen W, et al.. Does asthma increase the mortality of ' 'patients with COVID-19?: A systematic review and meta-analysis. Int Arch ' 'Allergy Immunol. 2021, 182:76-82. 10.1159/000510953', 'journal-title': 'Int Arch Allergy Immunol'}, { 'key': 'ref17', 'doi-asserted-by': 'publisher', 'DOI': '10.1177/1479973120986806', 'article-title': 'Contribution of pulmonary diseases to COVID-19 mortality in a diverse ' 'urban community of New York', 'volume': '18', 'author': 'Girardin JL', 'year': '2021', 'unstructured': 'Girardin JL, Seixas A, Ramos Cejudo J, Osorio RS, Avirappattu G, Reid M, ' 'Parthasarathy S. Contribution of pulmonary diseases to COVID-19 ' 'mortality in a diverse urban community of New York. Chron Respir Dis. ' '2021, 18:1479973120986806. 10.1177/1479973120986806', 'journal-title': 'Chron Respir Dis'}, { 'key': 'ref18', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S2213-2600(21)00013-8', 'article-title': 'Risk of adverse outcomes in patients with underlying respiratory ' 'conditions admitted to hospital with COVID-19: a national, multicentre ' 'prospective cohort study using the ISARIC WHO Clinical Characterisation ' 'Protocol UK', 'volume': '9', 'author': 'Bloom CI', 'year': '2021', 'unstructured': 'Bloom CI, Drake TM, Docherty AB, et al.. Risk of adverse outcomes in ' 'patients with underlying respiratory conditions admitted to hospital ' 'with COVID-19: a national, multicentre prospective cohort study using ' 'the ISARIC WHO Clinical Characterisation Protocol UK. Lancet Respir Med. ' '2021, 9:699-711. 10.1016/S2213-2600(21)00013-8', 'journal-title': 'Lancet Respir Med'}, { 'key': 'ref19', 'doi-asserted-by': 'publisher', 'DOI': '10.1513/AnnalsATS.202007-803OC', 'article-title': 'The impact of high-flow nasal cannula use on patient mortality and the ' 'availability of mechanical ventilators in COVID-19', 'volume': '18', 'author': 'Gershengorn HB', 'year': '2021', 'unstructured': 'Gershengorn HB, Hu Y, Chen JT, Hsieh SJ, Dong J, Gong MN, Chan CW. The ' 'impact of high-flow nasal cannula use on patient mortality and the ' 'availability of mechanical ventilators in COVID-19. Ann Am Thorac Soc. ' '2021, 18:623-31. 10.1513/AnnalsATS.202007-803OC', 'journal-title': 'Ann Am Thorac Soc'}, { 'key': 'ref20', 'doi-asserted-by': 'publisher', 'DOI': '10.1186/s12890-021-01401-0', 'article-title': 'Prone during pandemic: development and implementation of a ' 'quality-based protocol for proning severe COVID-19 hypoxic lung failure ' 'patients in situationally or historically low resource hospitals', 'volume': '21', 'author': 'Astua AJ', 'year': '2021', 'unstructured': 'Astua AJ, Michaels EK, Michaels AJ. Prone during pandemic: development ' 'and implementation of a quality-based protocol for proning severe ' 'COVID-19 hypoxic lung failure patients in situationally or historically ' 'low resource hospitals. BMC Pulm Med. 2021, 21:25. ' '10.1186/s12890-021-01401-0', 'journal-title': 'BMC Pulm Med'}, { 'key': 'ref21', 'doi-asserted-by': 'publisher', 'DOI': '10.1186/s13054-021-03552-2', 'article-title': 'Prone position in intubated, mechanically ventilated patients with ' 'COVID-19: a multi-centric study of more than 1000 patients', 'volume': '25', 'author': 'Langer T', 'year': '2021', 'unstructured': 'Langer T, Brioni M, Guzzardella A, et al.. Prone position in intubated, ' 'mechanically ventilated patients with COVID-19: a multi-centric study of ' 'more than 1000 patients. Crit Care. 2021, 25:128. ' '10.1186/s13054-021-03552-2', 'journal-title': 'Crit Care'}, { 'key': 'ref22', 'doi-asserted-by': 'publisher', 'DOI': '10.5005/jp-journals-10071-23816', 'article-title': 'Timing of invasive mechanical ventilation and mortality among patients ' 'with severe COVID-19-associated acute respiratory distress syndrome', 'volume': '25', 'author': 'Zirpe KG', 'year': '2021', 'unstructured': 'Zirpe KG, Tiwari AM, Gurav SK, et al.. Timing of invasive mechanical ' 'ventilation and mortality among patients with severe COVID-19-associated ' 'acute respiratory distress syndrome. Indian J Crit Care Med. 2021, ' '25:493-8. 10.5005/jp-journals-10071-23816', 'journal-title': 'Indian J Crit Care Med'}, { 'key': 'ref23', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.aucc.2020.10.009', 'article-title': 'Mechanical ventilation and mortality among 223 critically ill patients ' 'with coronavirus disease 2019: a multicentric study in Germany', 'volume': '34', 'author': 'Roedl K', 'year': '2021', 'unstructured': 'Roedl K, Jarczak D, Thasler L, et al.. Mechanical ventilation and ' 'mortality among 223 critically ill patients with coronavirus disease ' '2019: a multicentric study in Germany. Aust Crit Care. 2021, 34:167-75. ' '10.1016/j.aucc.2020.10.009', 'journal-title': 'Aust Crit Care'}, { 'key': 'ref24', 'doi-asserted-by': 'publisher', 'DOI': '10.5935/0103-507X.20200082', 'article-title': 'Clinical characteristics and predictors of mechanical ventilation in ' 'patients with COVID-19 hospitalized in Southern Brazil', 'volume': '32', 'author': 'Bastos GA', 'year': '2020', 'unstructured': 'Bastos GA, Azambuja AZ, Polanczyk CA, et al.. Clinical characteristics ' 'and predictors of mechanical ventilation in patients with COVID-19 ' 'hospitalized in Southern Brazil. Rev Bras Ter Intensiva. 2020, ' '32:487-92. 10.5935/0103-507X.20200082', 'journal-title': 'Rev Bras Ter Intensiva'}, { 'key': 'ref25', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMoa2023184', 'article-title': 'Repurposed antiviral drugs for Covid-19 - interim WHO Solidarity Trial ' 'results', 'volume': '384', 'author': 'Pan H', 'year': '2021', 'unstructured': 'Pan H, Peto R, Henao-Restrepo AM, et al.. Repurposed antiviral drugs for ' 'Covid-19 - interim WHO Solidarity Trial results. N Engl J Med. 2021, ' '384:497-511. 10.1056/NEJMoa2023184', 'journal-title': 'N Engl J Med'}, { 'key': 'ref26', 'doi-asserted-by': 'publisher', 'DOI': '10.1097/MJT.0000000000001402', 'article-title': 'Ivermectin for prevention and treatment of COVID-19 infection: a ' 'systematic review, meta-analysis, and trial sequential analysis to ' 'inform clinical guidelines', 'volume': '28', 'author': 'Bryant A', 'year': '2021', 'unstructured': 'Bryant A, Lawrie TA, Dowswell T, Fordham EJ, Mitchell S, Hill SR, Tham ' 'TC. Ivermectin for prevention and treatment of COVID-19 infection: a ' 'systematic review, meta-analysis, and trial sequential analysis to ' 'inform clinical guidelines. Am J Ther. 2021, 28:e434-60. ' '10.1097/MJT.0000000000001402', 'journal-title': 'Am J Ther'}, { 'key': 'ref27', 'doi-asserted-by': 'publisher', 'DOI': '10.31083/j.rcm2202033', 'article-title': 'A case of COVID-19 infection quickly relieved after nasal instillations ' 'and gargles with povidone iodine', 'volume': '22', 'author': 'Blasi C', 'year': '2021', 'unstructured': 'Blasi C. A case of COVID-19 infection quickly relieved after nasal ' 'instillations and gargles with povidone iodine. Rev Cardiovasc Med. ' '2021, 22:269-70. 10.31083/j.rcm2202033', 'journal-title': 'Rev Cardiovasc Med'}, { 'key': 'ref28', 'doi-asserted-by': 'publisher', 'DOI': '10.31744/einstein_journal/2021CE6419', 'article-title': 'Use of mouthwashes in the management of COVID-19 patients in intensive ' 'care units: recommendations and current evidence', 'volume': '19', 'author': 'Tovani-Palone MR', 'year': '2021', 'unstructured': 'Tovani-Palone MR, Shamsoddin E. Use of mouthwashes in the management of ' 'COVID-19 patients in intensive care units: recommendations and current ' 'evidence. Einstein (Sao Paulo). 2021, 19:eCE6419. ' '10.31744/einstein_journal/2021CE6419', 'journal-title': 'Einstein (Sao Paulo)'}, { 'key': 'ref29', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.dsx.2021.05.019', 'article-title': 'Mucormycosis in COVID-19: a systematic review of cases reported ' 'worldwide and in India', 'volume': '15', 'author': 'Singh AK', 'year': '2021', 'unstructured': 'Singh AK, Singh R, Joshi SR, Misra A. Mucormycosis in COVID-19: a ' 'systematic review of cases reported worldwide and in India. Diabetes ' 'Metab Syndr. 2021, 15:102146. 10.1016/j.dsx.2021.05.019', 'journal-title': 'Diabetes Metab Syndr'}, { 'key': 'ref30', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.mycmed.2017.11.006', 'article-title': 'Povidone iodine soaked gelfoam for the treatment of recalcitrant ' 'otomycosis\xa0-\xa0our experiences at a tertiary care teaching hospital ' 'of eastern India', 'volume': '28', 'author': 'Swain SK', 'year': '2018', 'unstructured': 'Swain SK, Behera IC, Sahu MC, Das A. Povidone iodine soaked gelfoam for ' 'the treatment of recalcitrant otomycosis\xa0-\xa0our experiences at a ' 'tertiary care teaching hospital of eastern India. J Mycol Med. 2018, ' '28:122-7. 10.1016/j.mycmed.2017.11.006', 'journal-title': 'J Mycol Med'}], 'container-title': ['Cureus'], 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.cureus.com/articles/73667-determinants-of-outcome-among-critically-ill-police-personnel-with-covid-19-a-retrospective-observational-study-from-andhra-pradesh-india', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2021, 12, 13]], 'date-time': '2021-12-13T18:19:59Z', 'timestamp': 1639419599000}, 'score': 1, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 12, 13]]}, 'references-count': 30, 'URL': 'http://dx.doi.org/10.7759/cureus.20394', 'relation': {}, 'ISSN': ['2168-8184'], 'issn-type': [{'value': '2168-8184', 'type': 'print'}], 'subject': ['Aerospace Engineering'], 'published': {'date-parts': [[2021, 12, 13]]}}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit