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Supplementary Data — Ibuprofen for COVID-19: real-time meta analysis of 13 studies

@CovidAnalysis, October 2023
https://c19early.org/ibmeta.html
 
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Rinott -21% 1.21 [0.33-4.38] death 3/87 9/316 Improvement, RR [CI] Treatment Control Rinott -12% 1.12 [0.37-3.34] ventilation 4/87 13/316 Rinott -40% 1.40 [0.51-3.81] ICU 5/87 13/316 Abu Esba -170% 2.70 [0.33-22.0] death 1/40 11/357 Abu Esba 37% 0.63 [0.07-5.44] death 40 (n) 357 (n) Abu Esba -45% 1.45 [0.44-4.81] oxygen 40 (n) 357 (n) Abu Esba -18% 1.18 [0.59-2.36] hosp. 40 (n) 357 (n) Abu Esba -85% 1.85 [0.42-8.13] severe case 40 (n) 357 (n) Sobhy (DB RCT) 52% 0.48 [0.24-0.95] ICU 10/90 21/90 OT​1 Sobhy (DB RCT) 52% 0.48 [0.24-0.95] oxygen 10/90 21/90 OT​1 Sobhy (DB RCT) 26% 0.74 [0.58-0.94] hosp. time 90 (n) 90 (n) OT​1 Sobhy (DB RCT) 25% 0.75 [0.17-3.26] no recov. 3/90 4/90 OT​1 Sobhy (DB RCT) 43% 0.57 [0.25-1.29] no recov. 8/90 14/90 OT​1 Sobhy (DB RCT) 48% 0.52 [0.28-0.95] no recov. 13/90 25/90 OT​1 Sobhy (DB RCT) 41% 0.59 [0.37-0.94] no recov. 20/90 34/90 OT​1 Choi (PSM) -240% 3.40 [0.64-18.1] progression case control Samimagham -100% 2.00 [1.33-3.02] death 63 (n) 95 (n) Samimagham -428% 5.28 [1.82-15.3] severe case 14/63 4/95 Samimagham -13% 1.13 [1.02-1.25] progression 60/63 80/95 Kragholm 4% 0.96 [0.72-1.23] progression 264 (n) 3,738 (n) Wong -23% 1.23 [0.90-1.68] death population-based cohort Wong 17% 0.83 [0.56-1.25] death population-based cohort Reese (PSM) 9% 0.91 [0.62-1.35] death 5,737 (n) 5,737 (n) Reese (PSM) -303% 4.03 [3.69-4.40] severe case 5,737 (n) 5,737 (n) Drake 10% 0.90 [0.71-1.13] death n/a n/a Leal 3% 0.97 [0.94-1.00] cases n/a n/a Campbell (PSW) 0% 1.00 [0.99-1.01] death 1,814 (n) 20,311 (n) Campbell (PSW) 1% 0.99 [0.98-1.00] death 1,814 (n) 20,311 (n) Xie -12% 1.12 [0.92-1.38] hosp. population-based cohort OT​1 Xie -8% 1.08 [0.95-1.22] cases population-based cohort OT​1 Loucera 48% 0.52 [0.34-0.78] death 519 (n) 15,449 (n) Ibuprofen COVID-19 outcomes c19early.org October 2023 1 OT: comparison with other treatment Favors ibuprofen Favors control
Figure S1. All outcomes.
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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