The Association of Non-Steroidal Anti-Inflammatory Drugs with COVID-19 Severity and Mortality
Hamid Reza Samimagham, Mohsen Arabi, Dariush Hooshyar, Mitra Kazemijahromi
Archives of Clinical Infectious Diseases, doi:10.5812/archcid.106847
Background: No specific study has investigated the effect of non-steroidal anti inflammatory drugs (NSAIDs) and especially the effects of Ibuprofen on COVID-19, so far.
Objectives: The purpose of this study was to investigate the effect of Ibuprofen on the severity of COVID-19 and mortality caused by the disease. Methods: This study was conducted on 158 patients with COVID-19 who had consumed Ibuprofen, Gelofen, and Novafen for at least one week in the last three months. Patients were divided into three groups (mild, moderate and sever). The relationship among the severity of the disease and the history of ibuprofen consumption, diabetes, history of cardiovascular problems, hypertension, and GFR was investigated. Also, the association between the history of ibuprofen consumption, GFR ≤ 60 mL/min, hypertension, LDH ≥ 500 U/L, lymphocyte count ≤ 1500, and mortality was examined. Results: Our findings showed a significant relationship between the history of Ibuprofen before COVID-19 and the severity of COVID-19, as well as the mortality rate (P value < 0.001, adjusted odd ratio: 2, respectively). This study also showed a significant relationship among the severity of the disease and the history of smoking, diabetes, hypertension, history of cardiovascular diseases, and GFR. In addition, a significant relationship was found among GFR ≤ 60 mL/min mortality, diabetes, LDH ≥ 500 U/L, and lymphocyte count ≤ 1500.
Conclusions: Our study showed a significant relationship between the history of the consumption of ibuprofen and its compounds before COVID-19 and the severity of COVID-19, as well as the mortality rate of the patients with this disease, and accordingly, this result can suggest health policies during the epidemic of COVID-19.
References
Basille, Plouvier, Trouve, Duhaut, Andrejak et al., Non-steroidal anti-inflammatory drugs may worsen the course of community-acquired pneumonia: A cohort study, Lung,
doi:10.1007/s00408-016-9973-1Bourgeois, Ferroni, Leruez-Ville, Varon, Thumerelle et al., Nonsteroidal anti-inflammatory drug without antibiotics for acute viral infection increases the empyema risk in children: A matched case-control study, J Pediatr,
doi:10.1016/j.jpeds.2016.05.025Cheng, Luo, Wang, Zhang, Wang et al., Kidney disease is associated with in-hospital death of patients with COVID-19, Kidney Int,
doi:10.1016/j.kint.2020.03.005Crosby, Heimann, Burleson, Anzalone, Swanson et al., COVID-19: A review of therapeutics under investigation, J Am Coll Emerg Physicians Open
Cucinotta, Vanelli, WHO declares COVID-19 a pandemic, Acta Bio-Medica: Atenei Parmensis
Fang, Karakiulakis, Roth, Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?, Lancet Respir Med,
doi:10.1016/S2213-2600(20)30116-8Henry, De Oliveira, Benoit, Plebani, Lippi, Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis, Clin Chem Lab Med,
doi:10.1515/cclm-2020-0369Huang, Lim, Pranata, Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia -A systematic review, meta-analysis, and meta-regression, Diabetes Metab Syndr,
doi:10.1016/j.dsx.2020.04.018Kumar, Arora, Sharma, Anikhindi, Bansal et al., Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysis, Diabetes Metab Syndr,
doi:10.1016/j.dsx.2020.04.044Mehra, Desai, Kuy, Henry, Patel, Cardiovascular disease, drug therapy, and mortality in Covid-19, N Engl J Med,
doi:10.1056/NEJMoa2007621Mo, Xing, Xiao, Deng, Zhao et al., Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China, Clin Infect Dis,
doi:10.1093/cid/ciaa270Qin, Zhou, Hu, Zhang, Yang et al., Dysregulation of immune response in patients with COVID-19 in Wuhan, China, Clin Infect Dis,
doi:10.1093/cid/ciaa248Russell, Moss, George, Santaolalla, Cope et al., Associations between immune-suppressive and stimulating drugs and novel COVID-19-a systematic review of current evidence, Ecancermedicalscience,
doi:10.3332/ecancer.2020.1022Sohrabi, Alsafi, Neill, Khan, Kerwan et al., World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19), Int J Surg,
doi:10.1016/j.ijsu.2020.02.034Wang, Nie, Wang, Zhao, Xiong et al., Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia, J Infect Dis,
doi:10.1093/infdis/jiaa150Wang, Zuo, Liu, Zhang, Zhao et al., Clinical and laboratory predictors of in-hospital mortality in patients with COVID-19: A cohort study in Wuhan, China, Clin Infect Dis,
doi:10.1093/cid/ciaa538Yan, Yang, Wang, Ren, Zhang et al., Clinical characteristics and outcomes of patients with severe covid-19 with diabetes, BMJ Open Diabetes Res Care,
doi:10.1136/bmjdrc-2020-001343Zhao, Yao, Wang, Zheng, Gao et al., A comparative study on the clinical features of COVID-19 pneumonia to other pneumonias, Clin Infect Dis,
doi:10.1093/cid/ciaa247Zheng, Peng, Xu, Zhao, Liu et al., Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis, J Infect,
doi:10.1016/j.jinf.2020.04.021Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study, Lancet,
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'abstract': '<jats:p>Background: No specific study has investigated the effect of non-steroidal anti '
'inflammatory drugs (NSAIDs) and especially the effects of Ibuprofen on COVID-19, so far. '
'Objectives: The purpose of this study was to investigate the effect of Ibuprofen on the '
'severity of COVID-19 and mortality caused by the disease. Methods: This study was conducted '
'on 158 patients with COVID-19 who had consumed Ibuprofen, Gelofen, and Novafen for at least '
'one week in the last three months. Patients were divided into three groups (mild, moderate '
'and sever). The relationship among the severity of the disease and the history of ibuprofen '
'consumption, diabetes, history of cardiovascular problems, hypertension, and GFR was '
'investigated. Also, the association between the history of ibuprofen consumption, GFR ≤ 60 '
'mL/min, hypertension, LDH ≥ 500 U/L, lymphocyte count ≤ 1500, and mortality was examined. '
'Results: Our findings showed a significant relationship between the history of Ibuprofen '
'before COVID-19 and the severity of COVID-19, as well as the mortality rate (P value < '
'0.001, adjusted odd ratio: 2, respectively). This study also showed a significant '
'relationship among the severity of the disease and the history of smoking, diabetes, '
'hypertension, history of cardiovascular diseases, and GFR. In addition, a significant '
'relationship was found among GFR ≤ 60 mL/min mortality, diabetes, LDH ≥ 500 U/L, and '
'lymphocyte count ≤ 1500. Conclusions: Our study showed a significant relationship between the '
'history of the consumption of ibuprofen and its compounds before COVID-19 and the severity of '
'COVID-19, as well as the mortality rate of the patients with this disease, and accordingly, '
'this result can suggest health policies during the epidemic of COVID-19.</jats:p>',
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