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Risk of COVID-19 Diagnosis and Hospitalization in Patients with Osteoarthritis or Back Pain Treated with Ibuprofen Compared to Other NSAIDs or Paracetamol: A Network Cohort Study

Xie et al., Drugs, doi:10.1007/s40265-022-01822-z (date from preprint)
Jul 2022  
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Hospitalization -12% Improvement Relative Risk Case -8% Ibuprofen for COVID-19  Xie et al.  Prophylaxis Is prophylaxis with ibuprofen beneficial for COVID-19? Retrospective 1,697,522 patients in the USA (Feb - Oct 2020) Study compares with other NSAIDs, results vs. placebo may differ No significant difference in outcomes seen c19early.org Xie et al., Drugs, July 2022 Favorsibuprofen Favorsother NSAIDs 0 0.5 1 1.5 2+
PSM retrospective 1,697,522 osteoarthritis or back pain patients in the US, showing no significant differences in COVID-19 cases and hospitalization for ibuprofen vs. other NSAIDs.
Study covers ibuprofen and acetaminophen.
risk of hospitalization, 12.5% higher, HR 1.12, p = 0.26, Open Claims, PharMetrics Plus, both periods combined.
risk of case, 7.6% higher, HR 1.08, p = 0.25, Open Claims, PharMetrics Plus, both periods combined.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Xie et al., 13 Jul 2022, retrospective, USA, peer-reviewed, 9 authors, study period 1 February, 2020 - 31 October, 2020, this trial compares with another treatment - results may be better when compared to placebo.
This PaperIbuprofenAll
Risk of COVID-19 Diagnosis and Hospitalisation in Patients with Osteoarthritis or Back Pain Treated with Ibuprofen Compared to Other NSAIDs or Paracetamol: A Network Cohort Study
Junqing Xie, James T Brash, Cigdem Turkmen, Stefan Driessen, Giustino Varrassi, George Argyriou, Sarah Seager, Christian Reich, Daniel Prieto-Alhambra
Drugs, doi:10.1007/s40265-022-01822-z
Objective We aimed to investigate whether ibuprofen use, compared with other non-selective non-steroidal anti-inflammatory drugs (ns-NSAIDs), cyclooxygenase-2 inhibitors (COX-2i) or paracetamol, increases the risk of coronavirus disease 2019 (COVID-19) diagnosis or hospitalisation. Design A prevalent user and active comparator cohort study. Setting Two US claims databases (Open Claims and PharMetrics Plus) mapped to the Observational Medical Outcomes Partnership Common Data Model. Participants Insured patients with a history of osteoarthritis or back pain and receiving ibuprofen, other ns-NSAIDs, COX-2i or paracetamol between
or paracetamol, was not associated with an increased risk of susceptibility and severity of COVID-19. Supplementary Information The online version contains supplementary material available at https:// doi. org/ 10. 1007/ s40265-022-01822-z. Declarations Funding Abbott contracted IQVIA for the conduct of this study. Prof. Prieto-Alhambra receives funding from the UK National Institute for Health Research in the form of a Senior Research Fellowship, and as part of the Oxford National Institute for Health Research Biomedical Research Centre. Prof. Giustino Varrassi had a contract with Abbott International, as a consultant for scientific projects. He is also a consultant for scientific projects with Dompé Farmaceutici and Menarini Group. Ethics Approval These assets are de-identified, commercially available data products that could be purchased and licensed by any researcher. The collection and de-identification of these data assets is a process that is commercial intellectual property and not privileged to the data licensees and the co-authors on this study. Licensees of these data have signed data use agreements with the data vendors that detail the usage protocols for running retrospective research on these databases. All analyses performed in this study were in accordance with data use agreement terms as specified by the data owners. As these data are deemed commercial assets, there is no institutional review board applicable to the usage and dissemination of these result..
References
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Fernandez-Gutierrez, Leon, Madrid, Hospital admissions in inflammatory rheumatic diseases during the peak of COVID-19 pandemic: incidence and role of disease-modifying agents, Ther Adv Musculoskelet Dis, doi:10.1177/1759720X20962692
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DOI record: { "DOI": "10.1007/s40265-022-01822-z", "ISSN": [ "0012-6667", "1179-1950" ], "URL": "http://dx.doi.org/10.1007/s40265-022-01822-z", "alternative-id": [ "1822" ], "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Accepted", "name": "accepted", "order": 1, "value": "27 November 2022" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 2, "value": "24 January 2023" }, { "group": { "label": "Declarations", "name": "EthicsHeading" }, "name": "Ethics", "order": 1 }, { "group": { "label": "Funding", "name": "EthicsHeading" }, "name": "Ethics", "order": 2, "value": "Abbott contracted IQVIA for the conduct of this study. Prof. Prieto-Alhambra receives funding from the UK National Institute for Health Research in the form of a Senior Research Fellowship, and as part of the Oxford National Institute for Health Research Biomedical Research Centre. Prof. Giustino Varrassi had a contract with Abbott International, as a consultant for scientific projects. He is also a consultant for scientific projects with Dompé Farmaceutici and Menarini Group." }, { "group": { "label": "Conflicts of Interest/Competing Interests", "name": "EthicsHeading" }, "name": "Ethics", "order": 3, "value": "All authors have completed the ICMJE disclosure form at ExternalRef removed and declare the following interests: Dani Prieto-Alhambra receives funding from the UK National Institute for Health Research in the form of a senior research fellowship and from the Oxford National Institute for Health Research Biomedical Research Centre. Junqing Xie receives the Clarendon Fund and Jardine scholarship (University of Oxford) to support her DPhil study. Dani Prieto-Alhambra’s research group has received research grants from the European Medicines Agency, the Innovative Medicines Initiative, Amgen, Chiesi and UCB Biopharma; and consultancy or speaker fees from Astellas, Amgen, AstraZeneca and UCB Biopharma." }, { "group": { "label": "Ethics Approval", "name": "EthicsHeading" }, "name": "Ethics", "order": 4, "value": "These assets are de-identified, commercially available data products that could be purchased and licensed by any researcher. The collection and de-identification of these data assets is a process that is commercial intellectual property and not privileged to the data licensees and the co-authors on this study. Licensees of these data have signed data use agreements with the data vendors that detail the usage protocols for running retrospective research on these databases. All analyses performed in this study were in accordance with data use agreement terms as specified by the data owners. As these data are deemed commercial assets, there is no institutional review board applicable to the usage and dissemination of these result sets or required registration of the protocol with additional ethics oversight. Compliance with data use agreement terms, which stipulate how these data can be used and for what purpose, is sufficient for the licensing commercial entities." }, { "group": { "label": "Consent to Participate", "name": "EthicsHeading" }, "name": "Ethics", "order": 5, "value": "Not applicable." }, { "group": { "label": "Consent for Publication", "name": "EthicsHeading" }, "name": "Ethics", "order": 6, "value": "Not applicable." }, { "group": { "label": "Availability of Data and Material", "name": "EthicsHeading" }, "name": "Ethics", "order": 7, "value": "Patient-level data cannot be shared without approval from data custodians owing to local information governance and data protection regulations. Additional summary data, analytical code and detailed definitions of algorithms for identifying the events are available from the corresponding author on reasonable request to access the GitHub repository." }, { "group": { "label": "Code Availability", "name": "EthicsHeading" }, "name": "Ethics", "order": 8, "value": "Not applicable." }, { "group": { "label": "Authors’ Contributors", "name": "EthicsHeading" }, "name": "Ethics", "order": 9, "value": "JQ-X, DP-A, SS, CT and GV conceived the study and contributed to the study design. JQ-X, JB and JA conducted the statistical analyses. JQ-X and DP-A interpreted the results and wrote the manuscript. All authors contributed to writing the manuscript, approved the final version and had final responsibility for the decision to submit for publication. The lead authors (JQ-X and JB) affirm that this manuscript is an honest, accurate and transparent account of the study being reported, that no important aspects of the study have been omitted and that any discrepancies from the study as planned (and, if relevant, registered) have been explained. DP-A is the guarantor. 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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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