Non-steroidal anti-inflammatory agent use may not be associated with mortality of coronavirus disease 19

DOI record: { "DOI": "10.1038/s41598-021-84539-5", "ISSN": [ "2045-2322" ], "URL": "http://dx.doi.org/10.1038/s41598-021-84539-5", "abstract": "<jats:title>Abstract</jats:title><jats:p>Non-steroidal anti-inflammatory drugs (NSAIDs) have been widely used in patients with respiratory infection, but their safety in coronavirus disease 19 (Covid-19) patients has not been fully investigated. We evaluated an association between NSAID use and outcomes of Covid-19. This study was a retrospective observational cohort study based on insurance benefit claims sent to the Health Insurance Review and Assessment Service of Korea by May 15, 2020. These claims comprised all Covid-19-tested cases and history of medical service use for the past 3 years in these patients. The primary outcome was all-cause mortality, and the secondary outcome was need for ventilator care. Among 7590 patients diagnosed with Covid-19, two distinct cohorts were generated based on NSAID or acetaminophen prescription within 2 weeks before Covid-19 diagnosis. A total of 398 patients was prescribed NSAIDs, and 2365 patients were prescribed acetaminophen. After propensity score matching, 397 pairs of data set were generated, and all-cause mortality of the NSAIDs group showed no significant difference compared with the acetaminophen group (4.0% vs. 3.0%; hazard ratio [HR], 1.33; 95% confidence interval [CI], 0.63–2.88; <jats:italic>P</jats:italic> = 0.46). The rate of ventilator care also did not show significantly different results between the two groups (2.0% vs. 1.3%; HR, 1.60; 95% CI 0.53–5.30; <jats:italic>P</jats:italic> = 0.42). Use of NSAIDs was not associated with mortality or ventilator care in Covid-19 patients. NSAIDs may be safely used to relieve symptoms in patients with suspicion of Covid-19.</jats:p>", "alternative-id": [ "84539" ], "article-number": "5087", "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Received", "name": "received", "order": 1, "value": "1 September 2020" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "16 February 2021" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 3, "value": "3 March 2021" }, { "group": { "label": "Competing interests", "name": "EthicsHeading" }, "name": "Ethics", "order": 1, "value": "The authors declare no competing interests." } ], "author": [ { "affiliation": [], "family": "Park", "given": "Jungchan", "sequence": "first" }, { "affiliation": [], "family": "Lee", "given": "Seung-Hwa", "sequence": "additional" }, { "affiliation": [], "family": "You", "given": "Seng Chan", "sequence": "additional" }, { "affiliation": [], "family": "Kim", "given": "Jinseob", "sequence": "additional" }, { "affiliation": [], "family": "Yang", "given": "Kwangmo", "sequence": "additional" } ], "container-title": "Scientific Reports", "container-title-short": "Sci Rep", "content-domain": { "crossmark-restriction": false, "domain": [ "link.springer.com" ] }, "created": { "date-parts": [ [ 2021, 3, 3 ] ], "date-time": "2021-03-03T11:02:36Z", "timestamp": 1614769356000 }, "deposited": { "date-parts": [ [ 2021, 12, 2 ] ], "date-time": "2021-12-02T16:10:27Z", "timestamp": 1638461427000 }, "funder": [ { "award": [ "HI19C0811" ], "name": "Ministry of Health and Welfare, Korea" } ], "indexed": { "date-parts": [ [ 2022, 8, 25 ] ], "date-time": "2022-08-25T04:28:48Z", "timestamp": 1661401728997 }, "is-referenced-by-count": 7, "issue": "1", "issued": { "date-parts": [ [ 2021, 3, 3 ] ] }, "journal-issue": { "issue": "1", "published-print": { "date-parts": [ [ 2021, 12 ] ] } }, "language": "en", "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2021, 3, 3 ] ], "date-time": "2021-03-03T00:00:00Z", "timestamp": 1614729600000 } }, { "URL": "https://creativecommons.org/licenses/by/4.0", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2021, 3, 3 ] ], "date-time": "2021-03-03T00:00:00Z", "timestamp": 1614729600000 } } ], "link": [ { "URL": "http://www.nature.com/articles/s41598-021-84539-5.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "http://www.nature.com/articles/s41598-021-84539-5", "content-type": "text/html", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "http://www.nature.com/articles/s41598-021-84539-5.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "297", "original-title": [], "prefix": "10.1038", "published": { "date-parts": [ [ 2021, 3, 3 ] ] }, "published-online": { "date-parts": [ [ 2021, 3, 3 ] ] }, "published-print": { "date-parts": [ [ 2021, 12 ] ] }, "publisher": "Springer Science and Business Media LLC", "reference": [ { "key": "84539_CR1", "unstructured": "World Health Organization. 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