Non-steroidal anti-inflammatory agent use may not be associated with mortality of coronavirus disease 19

{ 'indexed': {'date-parts': [[2022, 8, 25]], 'date-time': '2022-08-25T04:28:48Z', 'timestamp': 1661401728997}, 'reference-count': 18, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2021, 3, 3]], 'date-time': '2021-03-03T00:00:00Z', 'timestamp': 1614729600000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2021, 3, 3]], 'date-time': '2021-03-03T00:00:00Z', 'timestamp': 1614729600000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'funder': [{'name': 'Ministry of Health and Welfare, Korea', 'award': ['HI19C0811']}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2021, 12]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>Non-steroidal anti-inflammatory drugs (NSAIDs) have ' 'been widely used in patients with respiratory infection, but their safety in coronavirus ' 'disease 19 (Covid-19) patients has not been fully investigated. We evaluated an association ' 'between NSAID use and outcomes of Covid-19. This study was a retrospective observational ' 'cohort study based on insurance benefit claims sent to the Health Insurance Review and ' 'Assessment Service of Korea by May 15, 2020. These claims comprised all Covid-19-tested cases ' 'and history of medical service use for the past 3\xa0years in these patients. The primary ' 'outcome was all-cause mortality, and the secondary outcome was need for ventilator care. ' 'Among 7590 patients diagnosed with Covid-19, two distinct cohorts were generated based on ' 'NSAID or acetaminophen prescription within 2\xa0weeks before Covid-19 diagnosis. A total of ' '398 patients was prescribed NSAIDs, and 2365 patients were prescribed acetaminophen. After ' 'propensity score matching, 397 pairs of data set were generated, and all-cause mortality of ' 'the NSAIDs group showed no significant difference compared with the acetaminophen group (4.0% ' 'vs. 3.0%; hazard ratio [HR], 1.33; 95% confidence interval [CI], 0.63–2.88; ' '<jats:italic>P</jats:italic>\u2009=\u20090.46). The rate of ventilator care also did not show ' 'significantly different results between the two groups (2.0% vs. 1.3%; HR, 1.60; 95% CI ' '0.53–5.30; <jats:italic>P</jats:italic>\u2009=\u20090.42). Use of NSAIDs was not associated ' 'with mortality or ventilator care in Covid-19 patients. NSAIDs may be safely used to relieve ' 'symptoms in patients with suspicion of Covid-19.</jats:p>', 'DOI': '10.1038/s41598-021-84539-5', 'type': 'journal-article', 'created': {'date-parts': [[2021, 3, 3]], 'date-time': '2021-03-03T11:02:36Z', 'timestamp': 1614769356000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 7, 'title': 'Non-steroidal anti-inflammatory agent use may not be associated with mortality of coronavirus ' 'disease 19', 'prefix': '10.1038', 'volume': '11', 'author': [ {'given': 'Jungchan', 'family': 'Park', 'sequence': 'first', 'affiliation': []}, {'given': 'Seung-Hwa', 'family': 'Lee', 'sequence': 'additional', 'affiliation': []}, {'given': 'Seng Chan', 'family': 'You', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jinseob', 'family': 'Kim', 'sequence': 'additional', 'affiliation': []}, {'given': 'Kwangmo', 'family': 'Yang', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2021, 3, 3]]}, 'reference': [ { 'key': '84539_CR1', 'unstructured': 'World Health Organization. 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Med.'}, { 'key': '84539_CR4', 'doi-asserted-by': 'publisher', 'first-page': '1054', 'DOI': '10.1016/S0140-6736(20)30566-3', 'volume': '395', 'author': 'F Zhou', 'year': '2020', 'unstructured': 'Zhou, F. et al. Clinical course and risk factors for mortality of adult ' 'inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. ' 'Lancet 395, 1054–1062. https://doi.org/10.1016/S0140-6736(20)30566-3 ' '(2020).', 'journal-title': 'Lancet'}, { 'key': '84539_CR5', 'doi-asserted-by': 'publisher', 'first-page': '769', 'DOI': '10.1016/S0140-6736(13)60900-9', 'volume': '382', 'author': "Coxib and Traditional NSAID Trialists' Collaboration", 'year': '2013', 'unstructured': 'Coxib and Traditional NSAID Trialists’ Collaboration et al. Vascular and ' 'upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: ' 'Meta-analyses of individual participant data from randomised trials. 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