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0 0.5 1 1.5 2+ Mortality -170% Improvement Relative Risk Mortality (b) 37% Oxygen therapy -45% Hospitalization -18% Severe case -85% c19early.org/ib Abu Esba et al. Ibuprofen for COVID-19 EARLY TREATMENT Favors ibuprofen Favors control
Ibuprofen and NSAID Use in COVID-19 Infected Patients Is Not Associated with Worse Outcomes: A Prospective Cohort Study
Abu Esba et al., Infectious Diseases and Therapy, doi:10.1007/s40121-020-00363-w
2 Nov 2020    Source   PDF   Share   Tweet
Prospective study of 503 COVID-19 cases in Saudi Arabia, 40 using ibuprofen during infection, and 357 not using NSAIDs, showing no significant differences in outcomes. Results are subject to confounding by indication.
risk of death, 169.5% higher, RR 2.70, p = 0.35, treatment 1 of 40 (2.5%), control 11 of 357 (3.1%), adjusted per study, multivariable.
risk of death, 36.8% lower, HR 0.63, p = 0.68, treatment 40, control 357, Cox proportional hazards.
risk of oxygen therapy, 44.8% higher, RR 1.45, p = 0.64, treatment 40, control 357, adjusted per study, multivariable.
risk of hospitalization, 18.2% higher, RR 1.18, p = 0.64, treatment 40, control 357, adjusted per study, multivariable.
risk of severe case, 84.8% higher, RR 1.85, p = 0.42, treatment 40, control 357, adjusted per study, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: substantial unadjusted confounding by indication likely.
Abu Esba et al., 2 Nov 2020, prospective, Saudi Arabia, peer-reviewed, 6 authors, study period 12 April, 2020 - 1 June, 2020.
Contact: abuesbala@ngha.med.sa.
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