Cyclooxygenase inhibitor use is associated with increased COVID-19 severity

Reese et al., medRxiv, doi:10.1101/2021.04.13.21255438

Apr 2021

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N3C retrospective 250,533 patients showing higher COVID-19 severity with ibuprofen use. Note that results for individual treatments are not included in the journal version or v2 of this preprint.

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This study includes ibuprofen, aspirin, and acetaminophen.

risk of death, 9.0% lower, HR 0.91, p = 0.65, treatment 5,737, control 5,737, propensity score matching, Cox proportional hazards, Table S56.

risk of severe case, 303.0% higher, OR 4.03, p < 0.001, treatment 5,737, control 5,737, propensity score matching, Table S48, RR approximated with OR.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Reese et al., 20 Apr 2021, retrospective, USA, preprint, 23 authors.

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