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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Hospitalization 89% Improvement Relative Risk ER visit 30% Recovery -19% Viral shedding -32% primary c19early.org/a Holubar et al. Favipiravir for COVID-19 RCT EARLY Favors favipiravir Favors control
Favipiravir for treatment of outpatients with asymptomatic or uncomplicated COVID-19: a double-blind randomized, placebo-controlled, phase 2 trial
Holubar et al., Clinical Infectious Diseases, doi:10.1093/cid/ciac312 (date from earlier preprint)
24 Nov 2021    Source   PDF   Share   Tweet
Small RCT 116 mITT patients in the USA, 59 treated with favipiravir, showing no significant differences with treatment.
risk of hospitalization, 89.0% lower, RR 0.11, p = 0.06, treatment 0 of 75 (0.0%), control 4 of 74 (5.4%), NNT 18, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of ER visit, 29.5% lower, RR 0.70, p = 0.56, treatment 5 of 75 (6.7%), control 7 of 74 (9.5%), NNT 36.
risk of no recovery, 19.0% higher, RR 1.19, p = 0.43, treatment 65, control 70, inverted to make RR<1 favor treatment, initial resolution of symptoms.
viral shedding, 31.6% higher, RR 1.32, p = 0.24, treatment 59, control 57, inverted to make RR<1 favor treatment, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Holubar et al., 24 Nov 2021, Double Blind Randomized Controlled Trial, USA, peer-reviewed, 26 authors, average treatment delay 5.0 days, conflicts of interest: Pfizer, Gates Foundation, Gilead, Regeneron, Janssen.
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