Clinical and treatment factors associated with the mortality of COVID-19 patients admitted to a referral hospital in Indonesia
Yovita Hartantri, Josephine Debora, Leonardus Widyatmoko, Gezy Giwangkancana, Hendarsyah Suryadinata, Evan Susandi, Elisabeth Hutajulu, Assica Permata Amalya Hakiman, Yesy Pusparini, Bachti Alisjahbana
The Lancet Regional Health - Southeast Asia, doi:10.1016/j.lansea.2023.100167
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Research in context Evidence before this study Before this study, we searched PubMed for articles that assessed factors associated with mortality in COVID-19 inpatients, using search terms ("COVID-19" OR "coronavirus") AND ("mortality" OR "death"), from March until April 2022. We found the mortality studies were mainly from China, America, and Europe that associated mortality with older age, male, and pre-existing comorbidities besides the severity of the disease itself. Indonesia had the second-highest total number of cases and deaths in South-East Asia. However, there were still limited studies and inadequate reliable data about COVID-19 mortality in Indonesia. Previously published studies in Indonesia reported a CFR of around 9.4% to 18%, associated with older age, male, pre-existing comorbidity, immediate ICU admission, and intubation. Laboratory parameters such as NLR, D-dimer, and lymphocyte count were also associated with a greater risk of overall mortality.
Added value of this study This study is a retrospective cohort study of hospitalized COVID-19 patients in a top referral hospital in Bandung of West Java, the largest province in Indonesia, during the first ten months of the epidemic. Our report is the most comprehensive mortality study in our region that analyzed the clinical characteristics, laboratory parameters, and treatments associated with survival outcomes. The case fatality rate of 14.9% was similar to previous..
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