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All Studies   Meta Analysis    Recent:   

The Association between Vitamin D and Zinc Status and the Progression of Clinical Symptoms among Outpatients Infected with SARS-CoV-2 and Potentially Non-Infected Participants: A Cross-Sectional Study

Golabi et al., Nutrients, doi:10.3390/nu13103368 (date from preprint)
Aug 2021  
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Odds of symptoms 90% Improvement Relative Risk Odds of symptoms (b) 81% Case 72% Vitamin D for COVID-19  Golabi et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 83 patients in Iran Improved recovery with higher vitamin D levels (p<0.000001) c19early.org Golabi et al., Nutrients, August 2021 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 81 treatments. c19early.org
Analysis of vitamin D and zinc levels in 53 PCR+ outpatients and 53 matched controls, showing lower zinc levels in COVID-19 patients, and increased risk of cases and symptoms with vitamin D deficiency. There was no significant difference in the use of supplements between cases and controls. IR.ABADANUMS.REC.1399.073.
This is the 93rd of 199 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 835,162 vigintillion).
Study covers zinc and vitamin D.
odds of symptoms, 90.0% lower, OR 0.10, p < 0.001, high D levels 34, low D levels 10, >30ng/mL vs. <20ng/mL, GEE regression, RR approximated with OR.
odds of symptoms, 81.0% lower, OR 0.19, p = 0.006, high D levels 34, low D levels 9, 20-30ng/mL vs. <20ng/mL, GEE regression, RR approximated with OR.
risk of case, 71.7% lower, OR 0.28, p = 0.07, high D levels 34 of 44 (77.3%) cases, 36 of 39 (92.3%) controls, NNT 3.5, case control OR, >30ng/mL vs. <20ng/mL.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Golabi et al., 26 Aug 2021, retrospective, Iran, peer-reviewed, 10 authors.
This PaperVitamin DAll
The Association between Vitamin D and Zinc Status and the Progression of Clinical Symptoms among Outpatients Infected with SARS-CoV-2 and Potentially Non-Infected Participants: A Cross-Sectional Study
Sahar Golabi, Maryam Adelipour, Sara Mobarak, Maghsud Piri, Maryam Seyedtabib, Reza Bagheri, Katsuhiko Suzuki, Damoon Ashtary-Larky, Fatemeh Maghsoudi, Mahshid Naghashpour
Nutrients, doi:10.3390/nu13103368
Vitamin D and zinc are important components of nutritional immunity. This study compared the serum concentrations of 25-hydroxyvitamin D (25(OH)D) and zinc in COVID-19 outpatients with those of potentially non-infected participants. The association of clinical symptoms with vitamin D and zinc status was also examined. A checklist and laboratory examination were applied to collect data in a cross-sectional study conducted on 53 infected outpatients with COVID-19 and 53 potentially non-infected participants. Serum concentration of 25(OH)D were not significantly lower in patients with moderate illness (19 ± 12 ng/mL) than patients with asymptomatic or mild illness (29 ± 18 ng/mL), with a trend noted for a lower serum concentration of 25(OH)D in moderate than asymptomatic or mild illness patients (p = 0.054). Infected patients (101 ± 18 µg/dL) showed a lower serum concentration of zinc than potentially non-infected participants (114 ± 13 µg/dL) (p = 0.01). Patients with normal (odds ratio (OR), 0.19; p ≤ 0.001) and insufficient (OR, 0.3; p = 0.007) vitamin D status at the second to seventh days of disease had decreased OR of general symptoms compared to patients with vitamin D deficiency. This study revealed the importance of 25(OH)D measurement to predict the progression of general and pulmonary symptoms and showed that infected patients had significantly lower zinc concentrations than potentially non-infected participants.
Informed Consent Statement: Informed consent was obtained from all participants involved in the study. Conflicts of Interest: The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
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A checklist and laboratory ' 'examination were applied to collect data in a cross-sectional study conducted on 53 infected ' 'outpatients with COVID-19 and 53 potentially non-infected participants. Serum concentration ' 'of 25(OH)D were not significantly lower in patients with moderate illness (19 ± 12 ng/mL) ' 'than patients with asymptomatic or mild illness (29 ± 18 ng/mL), with a trend noted for a ' 'lower serum concentration of 25(OH)D in moderate than asymptomatic or mild illness patients ' '(p = 0.054). Infected patients (101 ± 18 µg/dL) showed a lower serum concentration of zinc ' 'than potentially non-infected participants (114 ± 13 µg/dL) (p = 0.01). Patients with normal ' '(odds ratio (OR), 0.19; p ≤ 0.001) and insufficient (OR, 0.3; p = 0.007) vitamin D status at ' 'the second to seventh days of disease had decreased OR of general symptoms compared to ' 'patients with vitamin D deficiency. 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