REGEN-COV antibody cocktail (casirivimab/imdevimab) for the treatment of inpatients with early hospital-acquired COVID-19: a single center experience

{ 'institution': [{'name': 'Research Square'}], 'indexed': {'date-parts': [[2022, 5, 6]], 'date-time': '2022-05-06T11:11:21Z', 'timestamp': 1651835481347}, 'posted': {'date-parts': [[2022, 5, 5]]}, 'group-title': 'In Review', 'reference-count': 0, 'publisher': 'Research Square Platform LLC', 'license': [ { 'start': { 'date-parts': [[2022, 5, 5]], 'date-time': '2022-05-05T00:00:00Z', 'timestamp': 1651708800000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'accepted': {'date-parts': [[2021, 12, 14]]}, 'abstract': '<jats:title>Abstract</jats:title>\n' ' <jats:p>Inpatients with hospital-acquired (HA) COVID-19 have mortality rates above ' '30%. Subjects with early diagnosis of COVID-19 and risk factors for disease progression are ' 'suitable for treatment with anti-SARS-CoV-2 neutralizing monoclonal antibodies (mAbs). We ' 'retrospectively assessed the outcome of a cohort of hospitalized patients with laboratory ' 'confirmed SARS-CoV-2 nosocomial infection who were admitted to the COVID-19 general ward of ' 'an acute-care Italian hospital between October 25, 2020 and April 30, 2021. Patients ' 'receiving the REGEN-COV mAb cocktail (casirivimab/imdevimab) were compared with those ' 'receiving standard care. Of 34 patients, 11 (mean age, 73.1; 9 males) underwent treatment ' 'with REGEN-COV and 23 received standard care. The 2 study groups were well balanced regarding ' 'age, sex, comorbidities, acute illness severity at diagnosis of SARS-CoV-2 infection, and all ' 'participants had at least 2 risk factors for disease progression. Five of 11 patients in the ' 'REGEN-COV group and 16 of 23 in the standard care group were asymptomatic at diagnosis; the ' 'remaining had symptoms of mild COVID-19. All patients received REGEN-COV within 3 days of ' 'infection confirmation. Treatment with REGEN-COV was inversely associated with oxygen ' 'requirement for COVID-19 during hospital stay (OR 0.02, CI 0–0.52, p=0.0174). No 28-day ' 'deaths were registered in the REGEN-COV group, compared to 8 (34.8%) in the standard care ' 'group (p=0.0339). Kaplan-Meier analysis confirmed the survival advantage of REGEN-COV group ' '(log-rank p=0.00324). No serious adverse events related to REGEN-COV administration were ' 'recorded. Based on these findings, REGEN-COV appears safe and might prevent disease ' 'progression in high-risk inpatients with early diagnosis of HA-COVID-19.</jats:p>', 'DOI': '10.21203/rs.3.rs-1170976/v1', 'type': 'posted-content', 'created': {'date-parts': [[2022, 5, 5]], 'date-time': '2022-05-05T16:08:51Z', 'timestamp': 1651766931000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'REGEN-COV antibody cocktail (casirivimab/imdevimab) for the treatment of inpatients with early ' 'hospital-acquired COVID-19: a single center experience', 'prefix': '10.21203', 'author': [ { 'ORCID': 'http://orcid.org/0000-0001-6095-8403', 'authenticated-orcid': False, 'given': 'Antonio', 'family': 'Faraone', 'sequence': 'first', 'affiliation': [{'name': 'Ospedale San Giovanni di Dio'}]}, { 'given': 'Francesca', 'family': 'Fabbrizzi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, San Giovanni di Dio Hospital, ' 'Florence'}]}, { 'given': 'Tommaso', 'family': 'Picchioni', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, San Giovanni di Dio Hospital, ' 'Florence'}]}, { 'given': 'Elena', 'family': 'Lovicu', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, San Giovanni di Dio Hospital, ' 'Florence'}]}, { 'given': 'Lorenzo', 'family': 'Tofani', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Statistics, Computer Science, Applications, ' 'University of Florence, Florence'}]}, { 'given': 'Giulia', 'family': 'Scocchera', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, San Giovanni di Dio Hospital, ' 'Florence'}]}, { 'given': 'Aldo Lo', 'family': 'Forte', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, San Giovanni di Dio Hospital, ' 'Florence'}]}, { 'given': 'Andrea', 'family': 'Crociani', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, San Giovanni di Dio Hospital, ' 'Florence'}]}, { 'given': 'Paolo', 'family': 'Carrai', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, San Giovanni di Dio Hospital, ' 'Florence'}]}, { 'given': 'Serena', 'family': 'Sbaragli', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, San Giovanni di Dio Hospital, ' 'Florence'}]}, { 'given': 'Michael', 'family': 'Bettucchi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, San Giovanni di Dio Hospital, ' 'Florence'}]}, { 'given': 'Alberto', 'family': 'Fortini', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine, San Giovanni di Dio Hospital, ' 'Florence'}]}], 'member': '8761', 'container-title': [], 'original-title': [], 'link': [ { 'URL': 'https://www.researchsquare.com/article/rs-1170976/v1', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.researchsquare.com/article/rs-1170976/v1.html', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 5, 5]], 'date-time': '2022-05-05T16:08:53Z', 'timestamp': 1651766933000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.researchsquare.com/article/rs-1170976/v1'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 5, 5]]}, 'references-count': 0, 'URL': 'http://dx.doi.org/10.21203/rs.3.rs-1170976/v1', 'relation': {}, 'published': {'date-parts': [[2022, 5, 5]]}, 'subtype': 'preprint'}