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Home   COVID-19 treatment studies for Casirivimab/imdevimab  COVID-19 treatment studies for Casirivimab/i..  C19 studies: Casirivimab/i..  Casirivimab/i..   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.5 1 1.5 2+ ICU admission 89% Improvement Relative Risk Oxygen therapy 85% Hospitalization 75% c19early.org/r Bierle et al. Casirivimab/i.. for COVID-19 EARLY Favors casirivimab/im.. Favors control
Monoclonal Antibody Treatment of Breakthrough COVID-19 in Fully Vaccinated Individuals with High-Risk Comorbidities
Bierle et al., The Journal of Infectious Diseases, doi:10.1093/infdis/jiab570 (date from earlier preprint)
Bierle et al., Monoclonal Antibody Treatment of Breakthrough COVID-19 in Fully Vaccinated Individuals with High-Risk.., The Journal of Infectious Diseases, doi:10.1093/infdis/jiab570 (date from earlier preprint)
Oct 2021   Source   PDF  
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Retrospective 1,395 vaccinated COVID-19 cases, showing significantly lower hospitalization and oxygen supplementation with monoclonal antibody treatment, primarily casirivimab-imdevimab. Hospitalization was significantly associated with comorbidities.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron [Liu, Sheward, Tatham, VanBlargan]. This study is excluded in meta analysis: patients were treated with different medications, results specific to each medication were not reported.
risk of ICU admission, 88.9% lower, RR 0.11, p = 0.16, treatment 0 of 527 (0.0%), control 5 of 868 (0.6%), NNT 174, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of oxygen therapy, 85.3% lower, RR 0.15, p < 0.001, treatment 5 of 527 (0.9%), control 56 of 868 (6.5%), NNT 18, odds ratio converted to relative risk.
risk of hospitalization, 75.3% lower, RR 0.25, p < 0.001, treatment 14 of 527 (2.7%), control 93 of 868 (10.7%), NNT 12, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Conflicts of interest: research funding from the drug patent holder.
Bierle et al., 20 Oct 2021, retrospective, USA, peer-reviewed, 7 authors, average treatment delay 5.0 days.
Contact: razonable.raymund@mayo.edu.
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Abstract: Monoclonal Antibody Treatment of Breakthrough COVID-19 in Fully Vaccinated Individuals with High-Risk Comorbidities 1 Dennis M. Bierle, 1Ravindra Ganesh, 1Sidna Tulledge-Scheitel, 2Sara N. Hanson, 3Lori L. Arndt, Caroline G. Wilker, 1Raymund R. Razonable 4 us cr ip t Mayo Clinic, Rochester, MN, USA 2Mayo Clinic Health Systems, Mankato, MN, USA 3Mayo Clinic Health Systems, Eau Claire, WI, USA and 4Mayo Clinic Health Systems – Franciscan Healthcare, LaCrosse, WI, USA Correspondence: Raymund R Razonable, MD Mayo Clinic pt e 40-word summary d Razonable.raymund@mayo.edu M 200 First Street SW, Rochester, MN 55905 an Division of Infectious Diseases Breakthrough COVID-19 may occur among vaccinated individuals with a high number of medical ce comorbidities, especially during the SARS-CoV-2 Delta surge. Anti-spike monoclonal antibody Ac treatment was associated with significantly lower rates of hospitalization, particularly among highrisk persons. © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 1 Abstract Breakthrough COVID-19 may occur in fully vaccinated persons. In this cohort of 1395 persons (mean age, 54.3 years; 60% female; median body mass index, 30.7) who developed breakthrough COVID19, there were 107 (7.7%) who required hospitalization by day 28. Hospitalization was significantly t was significantly associated with a lower risk of hospitalization (Odds Ratio: 0.227; 95% confidence us cr ip interval, 0.128 - 0.403; p<0.001). The number needed to treat (NNT) to prevent one hospitalization was 225 among the lowest-risk patient group compared to NNT of 4 among those with highest numbers of medical comorbidity. Ac ce pt e d M an Keywords: breakthrough covid-19, casirivimab-imdevimab, vaccination, covid-19, SARS-CoV-2, outcome, hospitalization 2 associated with the number of medical comorbidities. Anti-spike monoclonal antibody treatment Footnotes Funding: Mayo Clinic t us cr ip Conflict of Interest Statement: Dr. Razonable is principal investigator of research funded by Regeneron, Roche, Gilead (all funds an provided to his institution), and is a member of Data Safety Monitoring Board of Novartis, on projects not directly related to this submission. Dr. Razonable received research funds from the M Mayo Clinic for studies on monoclonal antibodies for COVID-19. Ac ce pt e d All other no conflict to report. 3 Ethical approval: This study was approved by the Mayo Clinic Institutional Review Board.
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