The Clinical Significance of Vitamin D and Zinc Levels with Respect to Immune Response in COVID-19 Positive Children
Ahmet Doğan, İmran Dumanoğlu Doğan, MD Metin Uyanık, Mehmet Tolga Köle, Kemal Pişmişoğlu
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmac072
Aim: In this study, we aimed to evaluate serum vitamin D and zinc levels in children diagnosed with cor- onavirus disease 2019 (COVID-19).
Materials and methods: In this study, 88 children with COVID-19 disease and 88 healthy children aged 1-18 years were enrolled between 01 July 2021 and 30 October 2021 in the Pediatrics Clinic of Tekirda g C ¸orlu State Hospital. Serum vitamin D and zinc levels have been measured and NCSS (Number Cruncher Statistical System) program has been utilized for statistical analysis. Results: We included 88 COVID-19 positive pediatric patients [50% (n ¼ 44) female] and 88 healthy children [48.86% (n ¼ 43) female] in this study. The mean serum vitamin D levels of COVID-19 positive patients were statistically significantly lower than the control group (p ¼ 0.0001). The zinc mean values of the study group were found to be statistically significantly lower than the control group (p ¼ 0.0001). There was a statistically significant correlation between serum vitamin D and zinc values in all patient groups (r ¼ 0.245, p ¼ 0.001).
Conclusion: As a result, zinc and vitamin D levels were observed lower in COVID-19 patients than in healthy individuals. Since there is no defined treatment protocol for COVID-19 infection on children yet, zinc and vitamin D supplementation can be used as a supportive treatment in COVID-19 infection.
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'abstract': '<jats:title>Abstract</jats:title>\n'
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' <jats:title>Aim</jats:title>\n'
' <jats:p>In this study, we aimed to evaluate serum vitamin D and zinc levels '
'in children diagnosed with coronavirus disease 2019 (COVID-19).</jats:p>\n'
' </jats:sec>\n'
' <jats:sec>\n'
' <jats:title>Materials and methods</jats:title>\n'
' <jats:p>In this study, 88 children with COVID-19 disease and 88 healthy '
'children aged 1–18\u2009years were enrolled between 01 July 2021 and 30 October 2021 in the '
'Pediatrics Clinic of Tekirdağ Çorlu State Hospital. Serum vitamin D and zinc levels have been '
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'statistical analysis.</jats:p>\n'
' </jats:sec>\n'
' <jats:sec>\n'
' <jats:title>Results</jats:title>\n'
' <jats:p>We included 88 COVID-19 positive pediatric patients [50% (n\u2009'
'=\u200944) female] and 88 healthy children [48.86% (n\u2009=\u200943) female] in this study. '
'The mean serum vitamin D levels of COVID-19 positive patients were statistically '
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' </jats:sec>\n'
' <jats:sec>\n'
' <jats:title>Conclusion</jats:title>\n'
' <jats:p>As a result, zinc and vitamin D levels were observed lower in '
'COVID-19 patients than in healthy individuals. Since there is no defined treatment protocol '
'for COVID-19 infection on children yet, zinc and vitamin D supplementation can be used as a '
'supportive treatment in COVID-19 infection.</jats:p>\n'
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