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0 0.5 1 1.5 2+ Case 77% Improvement Relative Risk c19early.org/z Doğan et al. Zinc for COVID-19 Sufficiency Are zinc levels associated with COVID-19 outcomes? Prospective study of 176 patients in Turkey (Jul - Oct 2021) Fewer cases with higher zinc levels (p=0.0031) Doğan et al., J. Tropical Pediatrics, doi:10.1093/tropej/fmac072 Favors zinc Favors control

The Clinical Significance of Vitamin D and Zinc Levels with Respect to Immune Response in COVID-19 Positive Children

Doğan et al., Journal of Tropical Pediatrics, doi:10.1093/tropej/fmac072
Doğan et al., The Clinical Significance of Vitamin D and Zinc Levels with Respect to Immune Response in COVID-19 Positive.., Journal of Tropical Pediatrics, doi:10.1093/tropej/fmac072
Aug 2022   Source   PDF  
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Prospective study of 88 pediatric COVID-19 patients and 88 healthy controls, showing significantly lower zinc and vitamin D levels in COVID-19 patients.
This study includes vitamin D and zinc.
risk of case, 76.7% lower, OR 0.23, p = 0.003, high zinc levels (≥60µg/dl) 67 of 88 (76.1%) cases, 82 of 88 (93.2%) controls, NNT 3.0, case control OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Doğan et al., 4 Aug 2022, prospective, Turkey, peer-reviewed, 5 authors, study period 1 July, 2021 - 30 October, 2021.
Contact: mehmet_tolga@hotmail.com.
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The Clinical Significance of Vitamin D and Zinc Levels with Respect to Immune Response in COVID-19 Positive Children
Ahmet Doğan, İmran Dumanoğlu Doğan, MD Metin Uyanık, Mehmet Tolga Köle, Kemal Pişmişoğlu
Journal of Tropical Pediatrics, doi:10.1093/tropej/fmac072
Aim: In this study, we aimed to evaluate serum vitamin D and zinc levels in children diagnosed with cor- onavirus disease 2019 (COVID-19). Materials and methods: In this study, 88 children with COVID-19 disease and 88 healthy children aged 1-18 years were enrolled between 01 July 2021 and 30 October 2021 in the Pediatrics Clinic of Tekirda g C ¸orlu State Hospital. Serum vitamin D and zinc levels have been measured and NCSS (Number Cruncher Statistical System) program has been utilized for statistical analysis. Results: We included 88 COVID-19 positive pediatric patients [50% (n ¼ 44) female] and 88 healthy children [48.86% (n ¼ 43) female] in this study. The mean serum vitamin D levels of COVID-19 positive patients were statistically significantly lower than the control group (p ¼ 0.0001). The zinc mean values of the study group were found to be statistically significantly lower than the control group (p ¼ 0.0001). There was a statistically significant correlation between serum vitamin D and zinc values in all patient groups (r ¼ 0.245, p ¼ 0.001). Conclusion: As a result, zinc and vitamin D levels were observed lower in COVID-19 patients than in healthy individuals. Since there is no defined treatment protocol for COVID-19 infection on children yet, zinc and vitamin D supplementation can be used as a supportive treatment in COVID-19 infection.
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