Efficacy of favipiravir in COVID-19 treatment: a multi-center randomized study

{ 'indexed': {'date-parts': [[2024, 5, 13]], 'date-time': '2024-05-13T16:01:05Z', 'timestamp': 1715616065990}, 'update-to': [ { 'updated': { 'date-parts': [[2021, 11, 22]], 'date-time': '2021-11-22T00:00:00Z', 'timestamp': 1637539200000}, 'DOI': '10.1007/s00705-021-04956-9', 'type': 'retraction', 'label': 'Retraction'}], 'reference-count': 28, 'publisher': 'Springer Science and Business Media LLC', 'issue': '3', 'license': [ { 'start': { 'date-parts': [[2021, 1, 25]], 'date-time': '2021-01-25T00:00:00Z', 'timestamp': 1611532800000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.springer.com/tdm'}, { 'start': { 'date-parts': [[2021, 1, 25]], 'date-time': '2021-01-25T00:00:00Z', 'timestamp': 1611532800000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://www.springer.com/tdm'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2021, 3]]}, 'DOI': '10.1007/s00705-021-04956-9', 'type': 'journal-article', 'created': {'date-parts': [[2021, 1, 25]], 'date-time': '2021-01-25T10:06:58Z', 'timestamp': 1611569218000}, 'page': '949-954', 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 108, 'title': 'RETRACTED ARTICLE: Efficacy of favipiravir in COVID-19 treatment: a multi-center randomized ' 'study', 'prefix': '10.1007', 'volume': '166', 'author': [ {'given': 'Hany M.', 'family': 'Dabbous', 'sequence': 'first', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-4366-2218', 'authenticated-orcid': False, 'given': 'Sherief', 'family': 'Abd-Elsalam', 'sequence': 'additional', 'affiliation': []}, {'given': 'Manal H.', 'family': 'El-Sayed', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ahmed F.', 'family': 'Sherief', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fatma F. S.', 'family': 'Ebeid', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Mohamed Samir Abd', 'family': 'El Ghafar', 'sequence': 'additional', 'affiliation': []}, {'given': 'Shaimaa', 'family': 'Soliman', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mohamed', 'family': 'Elbahnasawy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rehab', 'family': 'Badawi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mohamed Awad', 'family': 'Tageldin', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2021, 1, 25]]}, 'reference': [ { 'issue': '8', 'key': '4956_CR1', 'doi-asserted-by': 'publisher', 'first-page': '727', 'DOI': '10.1056/NEJMoa2001017', 'volume': '382', 'author': 'N Zhu', 'year': '2020', 'unstructured': 'Zhu N, Zhang D, Wang W, Li X, Yang B, Song J et al (2020) A novel ' 'coronavirus from patients with pneumonia in China, 2019. N Engl J Med. ' '382(8):727–733', 'journal-title': 'N Engl J Med.'}, { 'issue': '2', 'key': '4956_CR2', 'doi-asserted-by': 'publisher', 'first-page': '130', 'DOI': '10.1111/resp.13196', 'volume': '23', 'author': 'Y Yin', 'year': '2018', 'unstructured': 'Yin Y, Wunderink RG (2018) MERS, SARS and other coronaviruses as causes ' 'of pneumonia. Respirology 23(2):130–137', 'journal-title': 'Respirology'}, { 'key': '4956_CR3', 'volume-title': 'Features, evaluation and treatment coronavirus (COVID-19)', 'author': 'M Cascella', 'year': '2012', 'unstructured': 'Cascella M, Rajnik M, Cuomo A et al (2012) Features, evaluation and ' 'treatment coronavirus (COVID-19). StatPearls Publishing, Treasure ' 'Island'}, { 'key': '4956_CR4', 'doi-asserted-by': 'publisher', 'first-page': '754', 'DOI': '10.7326/M20-1334', 'volume': '172', 'author': 'J Yazdany', 'year': '2020', 'unstructured': 'Yazdany J, Kim AHJ (2020) Use of hydroxychloroquine and chloroquine ' 'during the COVID-19 pandemic: what every clinician should know. Ann ' 'Intern Med. 172:754–755', 'journal-title': 'Ann Intern Med.'}, { 'issue': '4', 'key': '4956_CR5', 'doi-asserted-by': 'publisher', 'first-page': '287', 'DOI': '10.7326/M20-2496', 'volume': '173', 'author': 'AV Hernandez', 'year': '2020', 'unstructured': 'Hernandez AV, Roman YM, Pasupuleti V et al (2020) Hydroxychloroquine or ' 'chloroquine for treatment or prophylaxis of COVID-19: a living ' 'systematic review. Ann Intern Med. 173(4):287–296', 'journal-title': 'Ann Intern Med.'}, { 'issue': '2', 'key': '4956_CR6', 'doi-asserted-by': 'publisher', 'first-page': '242', 'DOI': '10.1002/cpt.1844', 'volume': '108', 'author': 'YX Du', 'year': '2020', 'unstructured': 'Du YX, Chen XP (2020) Favipiravir: pharmacokinetics and concerns about ' 'clinical trials for 2019-nCoV infection. Clin Pharmacol Ther ' '108(2):242–247', 'journal-title': 'Clin Pharmacol Ther'}, { 'issue': '7', 'key': '4956_CR7', 'doi-asserted-by': 'publisher', 'first-page': 'e039730', 'DOI': '10.1136/bmjopen-2020-039730', 'volume': '10', 'author': 'M Arab-Zozani', 'year': '2020', 'unstructured': 'Arab-Zozani M, Hassanipour S, Ghoddoosi-Nejad D (2020) Favipiravir for ' 'treating patients with novel coronavirus (COVID-19): protocol for a ' 'systematic review and meta-analysis of randomised clinical trials. BMJ ' 'Open. 10(7):e039730', 'journal-title': 'BMJ Open.'}, { 'issue': '45', 'key': '4956_CR8', 'doi-asserted-by': 'publisher', 'first-page': '11613', 'DOI': '10.1073/pnas.1811345115', 'volume': '115', 'author': 'DH Goldhill', 'year': '2018', 'unstructured': 'Goldhill DH, Te Velthuis AJ, Fletcher RA et al (2018) The mechanism of ' 'resistance to favipiravir in influenza. Proc Natl Acad Sci ' '115(45):11613–11618', 'journal-title': 'Proc Natl Acad Sci'}, { 'key': '4956_CR9', 'doi-asserted-by': 'publisher', 'DOI': '10.1177/2472555220942123', 'author': 'W Zhu', 'year': '2020', 'unstructured': 'Zhu W, Chen CZ, Gorshkov K et al (2020) RNA-dependent RNA polymerase as ' 'a target for COVID-19 Drug discovery. SLAS DISCOV Adv Sci Drug Discov. ' 'https://doi.org/10.1177/2472555220942123', 'journal-title': 'SLAS DISCOV Adv Sci Drug Discov'}, { 'key': '4956_CR10', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/07391102.2020.1761882', 'author': 'AA Elfiky', 'year': '2020', 'unstructured': 'Elfiky AA (2020) SARS-CoV-2 RNA dependent RNA polymerase (RdRp) ' 'targeting: an in silico perspective. J Biomol Struct Dyn. ' 'https://doi.org/10.1080/07391102.2020.1761882', 'journal-title': 'J Biomol Struct Dyn'}, { 'key': '4956_CR11', 'doi-asserted-by': 'publisher', 'DOI': '10.2174/1871526520666200520112848', 'author': 'AA Mohamed', 'year': '2020', 'unstructured': 'Mohamed AA, Mohamed N, Mohamoud S et al (2020) SARS-CoV-2: the path of ' 'prevention and control. Infect Disord Drug Targets. ' 'https://doi.org/10.2174/1871526520666200520112848 (Online ahead of ' 'print)', 'journal-title': 'Infect Disord Drug Targets'}, { 'issue': '5', 'key': '4956_CR12', 'doi-asserted-by': 'publisher', 'first-page': '690', 'DOI': '10.1007/s12072-020-10072-8', 'volume': '14', 'author': 'SK Sarin', 'year': '2020', 'unstructured': 'Sarin SK, Choudhury A, Lau GK et al (2020) Pre-existing liver disease is ' 'associated with poor outcome in patients with SARS CoV2 infection; the ' 'APCOLIS Study (APASL COVID-19 Liver Injury Spectrum Study). Hepatol Int ' '14(5):690–700. https://doi.org/10.1007/s12072-020-10072-8', 'journal-title': 'Hepatol Int'}, { 'key': '4956_CR13', 'doi-asserted-by': 'publisher', 'DOI': '10.2174/1871526520666200726224802', 'author': 'S Abd-Elsalam', 'year': '2020', 'unstructured': 'Abd-Elsalam S, Elkadeem M, Glal KA (2020) Chloroquine as ' 'chemoprophylaxis for COVID-19: Will this work? Infect Disord Drug ' 'Targets. https://doi.org/10.2174/1871526520666200726224802 (Online ahead ' 'of print)', 'journal-title': 'Infect Disord Drug Targets.'}, { 'key': '4956_CR14', 'doi-asserted-by': 'publisher', 'DOI': '10.2174/1871530320999201117142305', 'author': 'S Abd-Elsalam', 'year': '2020', 'unstructured': 'Abd-Elsalam S, Esmail ES, Khalaf M et al (2020) Tanta protocol for ' 'management of COVID-19. Perspectives from a developing country. Endocr ' 'Metab Immune Disord Drug Targets. ' 'https://doi.org/10.2174/1871530320999201117142305 (Online ahead of ' 'print)', 'journal-title': 'Endocr Metab Immune Disord Drug Targets'}, { 'key': '4956_CR15', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.ijid.2020.03.071', 'author': 'M Xie', 'year': '2020', 'unstructured': 'Xie M, Chen Q (2020) Insight into 2019 novel coronavirus—an updated ' 'intrim review and lessons from SARS-CoV and MERS-CoV. Int J Infect Dis. ' 'https://doi.org/10.1016/j.ijid.2020.03.071 ([Epub ahead of print])', 'journal-title': 'Int J Infect Dis'}, { 'key': '4956_CR16', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jhep.2020.09.024', 'author': 'T Marjot', 'year': '2020', 'unstructured': 'Marjot T, Moon AM, Cook JA et al (2020) Outcomes following SARS-CoV-2 ' 'infection in patients with chronic liver disease: an international ' 'registry study. J Hepatol. https://doi.org/10.1016/j.jhep.2020.09.024 ' '(Online ahead of print. PMID: 33035628)', 'journal-title': 'J Hepatol'}, { 'key': '4956_CR17', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.eng.2020.03.007', 'author': 'Q Cai', 'year': '2020', 'unstructured': 'Cai Q, Yang M, Liu D et al (2020) Experimental treatment with ' 'favipiravir for COVID-19: an open-label control study. Engineering ' '(Beijing). https://doi.org/10.1016/j.eng.2020.03.007 ([Epub ahead of ' 'print])', 'journal-title': 'Engineering (Beijing)'}, { 'key': '4956_CR18', 'doi-asserted-by': 'publisher', 'first-page': '175', 'DOI': '10.3758/BF03193146', 'volume': '39', 'author': 'F Faul', 'year': '2007', 'unstructured': 'Faul F, Erdfelder E, Lang A-G et al (2007) A flexible statistical power ' 'analysis program for the social, behavioral, and biomedical sciences. ' 'Behav Res Methods 39:175–191', 'journal-title': 'Behav Res Methods'}, { 'key': '4956_CR19', 'unstructured': 'World Health Organization. Coronavirus disease (COVID-19) situation ' 'report—139. ' 'https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200607-covid-19-sitrep-139.pdf?sfvrsn=79dc6d08_2. ' 'Accessed 8 June 2020.'}, { 'key': '4956_CR20', 'doi-asserted-by': 'publisher', 'first-page': '17', 'DOI': '10.1016/j.antiviral.2014.02.014', 'volume': '105', 'author': 'L Oestereich', 'year': '2014', 'unstructured': 'Oestereich L, Lüdtke A, Wurr S et al (2014) Successful treatment of ' 'advanced Ebola virus infection with T-705 (favipiravir) in a small ' 'animal model. Antiviral Res 105:17–21', 'journal-title': 'Antiviral Res'}, { 'key': '4956_CR21', 'doi-asserted-by': 'publisher', 'first-page': '70', 'DOI': '10.1016/j.antiviral.2015.08.015', 'volume': '123', 'author': 'V Madelain', 'year': '2015', 'unstructured': 'Madelain V, Oestereich L, Graw F et al (2015) Ebola virus dynamics in ' 'mice treated with favipiravir. Antiviral Res 123:70–77', 'journal-title': 'Antiviral Res'}, { 'key': '4956_CR22', 'unstructured': 'Noda A, Shirai T, Nakajima H et al (2020) Case report: two cases of ' 'COVID-19 pneumonia including use of favipiravir. The Japanese ' 'Association for Infectious Diseases. ' 'http://www.kansensho.or.jp/uploads/files/topics/2019ncov/covid19_casereport_en_200408_2.pdf'}, { 'key': '4956_CR23', 'unstructured': 'Yokoyama K, Oguri T, Kato A et al (2020) Case report a case of COVID-19 ' 'pneumonia that did not worsen and was relieved by early administration ' 'of favipiravir and ciclesonide. ' 'http://www.kansensho.or.jp/uploads/files/topics/2019ncov/covid19_casereport_en_200406.pdf.'}, { 'key': '4956_CR24', 'doi-asserted-by': 'publisher', 'first-page': '1184', 'DOI': '10.4269/ajtmh.20-0290', 'volume': '102', 'author': 'PM Abena', 'year': '2020', 'unstructured': 'Abena PM et al (2020) Chloroquine and hydroxychloroquine for the ' 'prevention or treatment of COVID-19 in Africa: caution for inappropriate ' 'off-label use in healthcare settings. Am J Trop Med Hyg 102:1184–1188', 'journal-title': 'Am J Trop Med Hyg'}, { 'key': '4956_CR25', 'doi-asserted-by': 'publisher', 'first-page': '981', 'DOI': '10.1128/AAC.49.3.981-986.2005', 'volume': '49', 'author': 'Y Furuta', 'year': '2005', 'unstructured': 'Furuta Y et al (2005) Mechanism of action of T-705 against influenza ' 'virus. Antimicrob Agents Chemother. 49:981–986', 'journal-title': 'Antimicrob Agents Chemother.'}, { 'issue': '5', 'key': '4956_CR26', 'doi-asserted-by': 'crossref', 'first-page': '880', 'DOI': '10.1111/cts.12827', 'volume': '13', 'author': 'K Irie', 'year': '2020', 'unstructured': 'Irie K, Nakagawa A, Fujita H et al (2020) Pharmacokinetics of ' 'favipiravir in critically Ill patients with COVID-19. Clin Transl Sci. ' '13(5):880–885', 'journal-title': 'Clin Transl Sci.'}, { 'key': '4956_CR27', 'doi-asserted-by': 'publisher', 'first-page': '392', 'DOI': '10.1186/s13054-020-03078-z', 'volume': '24', 'author': 'K Doi', 'year': '2020', 'unstructured': 'Doi K, Ikeda M, Hayase N et al (2020) Nafamostat mesylate treatment ' 'incombination with favipiravir for patients critically ill with ' 'Covid-19: a case series. Crit Care 24:392', 'journal-title': 'Crit Care'}, { 'key': '4956_CR28', 'first-page': '101200', 'volume': '31', 'author': 'H Inoue', 'year': '2020', 'unstructured': 'Inoue H, Jinno M, Ohta S et al (2020) Combination treatment of ' 'short-course systemic corticosteroid and favipiravir in a successfully ' 'treated case of critically ill COVID-19 pneumonia with COPD. Respir Med ' 'Case Rep 31:101200', 'journal-title': 'Respir Med Case Rep'}], 'container-title': 'Archives of Virology', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1007/s00705-021-04956-9.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1007/s00705-021-04956-9/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1007/s00705-021-04956-9.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 10, 19]], 'date-time': '2023-10-19T01:58:46Z', 'timestamp': 1697680726000}, 'score': 1, 'resource': {'primary': {'URL': 'https://link.springer.com/10.1007/s00705-021-04956-9'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 1, 25]]}, 'references-count': 28, 'journal-issue': {'issue': '3', 'published-print': {'date-parts': [[2021, 3]]}}, 'alternative-id': ['4956'], 'URL': 'http://dx.doi.org/10.1007/s00705-021-04956-9', 'relation': {}, 'ISSN': ['0304-8608', '1432-8798'], 'subject': [], 'container-title-short': 'Arch Virol', 'published': {'date-parts': [[2021, 1, 25]]}, 'assertion': [ { 'value': '14 October 2020', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '25 November 2020', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '25 January 2021', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '3 August 2021', 'order': 4, 'name': 'change_date', 'label': 'Change Date', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': 'Clarification', 'order': 5, 'name': 'change_type', 'label': 'Change Type', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': "Editor's Note:The Editor-in-Chief is currently investigating this article as " 'concerns have been raised about the reporting of this clinical trial. Further ' 'editorial action will be taken as appropriate once the investigation into the ' 'concerns is complete and all parties have been given an opportunity to respond ' 'in full.', 'order': 6, 'name': 'change_details', 'label': 'Change Details', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '22 November 2021', 'order': 7, 'name': 'change_date', 'label': 'Change Date', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': 'Correction', 'order': 8, 'name': 'change_type', 'label': 'Change Type', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': 'This article has been retracted. Please see the Retraction Notice for more ' 'detail:', 'order': 9, 'name': 'change_details', 'label': 'Change Details', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': 'https://doi.org/10.1007/s00705-021-05307-4', 'URL': 'https://doi.org/10.1007/s00705-021-05307-4', 'order': 10, 'name': 'change_details', 'label': 'Change Details', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Compliance with ethical standards'}}, { 'value': 'There are no conflicts of interest.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Conflict of interest'}}, { 'value': 'This content has been made available to all.', 'name': 'free', 'label': 'Free to read'}]}