Characteristics and outcomes of COVID-19 patients with IPF: A multi-center retrospective study
Cilli et al.,
Characteristics and outcomes of COVID-19 patients with IPF: A multi-center retrospective study,
Respiratory Medicine and Research, doi:10.1016/j.resmer.2022.100900
Retrospective 46 idiopathic pulmonary fibrosis patients with COVID-19 in Turkey, showing lower mortality with favipiravir in unadjusted results, without statistical significance.
This study is excluded in the after exclusion results of meta
analysis:
unadjusted results with no group details.
risk of death, 37.5% lower, RR 0.62, p = 0.51, treatment 5 of 23 (21.7%), control 8 of 23 (34.8%), NNT 7.7.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Cilli et al., 3 Mar 2022, retrospective, Turkey, peer-reviewed, 10 authors.
Abstract: Respir. Med and Res 81 (2022) 100900
Available online at
ScienceDirect
www.sciencedirect.com
Original article
Characteristics and outcomes of COVID-19 patients with IPF: A
multi-center retrospective study
Aykut Cillia,*, Ismail Hantab, Fatih Uzera, Funda Coskunc, Can Sevincd, Pelin Pınar Denizb,
Mehmet Parlaka, Ersoy Altunokb, Kemal Can Tertemizd, Ahmet Ursavasc
a
Department of Respiratory Disease, Akdeniz University, Antalya, Turkey
Department of Respiratory Disease, Cukurova University, Adana, Turkey
c
Department of Respiratory Disease, Uludag University, Bursa, Turkey
d
Department of Respiratory Disease, Dokuz Eylul University, Izmır, Turkey
b
A R T I C L E
I N F O
Article History:
Received 16 November 2021
Revised 18 February 2022
Accepted 25 February 2022
Available online 3 March 2022
Key words:
Interstitial lung disease
Idiopathic pulmonary fibrosis
Outbreak
Pandemic
SARS-CoV-2
A B S T R A C T
Background: There are few data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (COVID19) infection in patients with idiopathic pulmonary fibrosis (IPF). The objective of this study is to describe
the characteristics and outcomes of IPF patients confirmed COVID-19 infection.
Methods: In this retrospective, multi-center, cohort study, patients from 4 hospital medical records with
known IPF and a COVID-19 diagnosis were identified. Demographic and clinical outcome data were
abstracted through a review of electronic medical records.
Results: Records for 46 patients with IPF and COVID-19 were abstracted. The mean age was 65§
10 years. The most common symptom was dyspnea, followed by fever and cough. Ground-glass opacities (n = 35, 83.3%) and consolidations (n = 11, 26.1%) were the main imaging features of the disease in
thorax computed tomography (CT). Twenty-four patients (52.1%) required hospitalization. Among the
hospitalized patients, 16 (66.6%) were admitted to the intensive care unit (ICU), and 10 (41.6%) underwent invasive mechanical ventilation. Thirteen patients (28.2%) died of COVID-19 complications. Mortality rate was significantly associated with lower DLCO/VA, long term oxygen therapy and
consolidation finding on CT of thorax (p<0.05). On multivariable analysis, neither factor was associated
with hospitalization or mortality.
Conclusions: IPF patients represent a vulnerable population for COVID-19, according to the high rate of hospitalization, ICU requirement, and mortality rate. Measures to minimize the risk of COVID-19 infection remain
key to protect IPF patients.
© 2022 SPLF and Elsevier Masson SAS. All rights reserved.
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