Early oral nutritional supplement improves COVID-19 outcomes among hospitalized older patients during the omicron wave
Chen et al.
, Early oral nutritional supplement improves COVID-19 outcomes among hospitalized older patients during the..
, Nutrition, doi:10.1016/j.nut.2023.112087
PSM retrospective 1,181 COVID-19 patients ≥60 years old in China, showing significantly lower mortality with a nutritional supplement. Hospitalization time and viral clearance time was improved with earlier initiation of treatment. The supplement contained 28 vitamins and minerals including vitamins A, C, D, B9, and zinc.
This study is excluded in meta
nutritional supplement containing 28 vitamins and minerals.
risk of death, 72.7% lower, RR 0.27, p = 0.03, treatment 3 of 258 (1.2%), control 11 of 258 (4.3%), NNT 32, propensity score matching.
risk of death, 93.0% lower, OR 0.07, p = 0.003, adjusted per study, <48hrs, multivariable, RR approximated with OR.
risk of death, 91.0% lower, OR 0.09, p = 0.005, adjusted per study, >48hrs, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chen et al., 21 May 2023, retrospective, China, peer-reviewed, mean age 78.0, 7 authors, study period April 2022 - June 2022, this trial uses multiple treatments in the treatment arm (combined with 27 vitamins and minerals) - results of individual treatments may vary.
Abstract: Journal Pre-proof
Early oral nutritional supplement improves COVID-19 outcomes
among hospitalized older patients during the omicron wave
Ying Chen , Yinfan Wu , Wei Ran , Jingjue Yuan ,
Zhangwei Yang , Shunjie Chen , Ying Wang
To appear in:
19 February 2023
16 May 2023
17 May 2023
Please cite this article as: Ying Chen , Yinfan Wu , Wei Ran , Jingjue Yuan , Zhangwei Yang ,
Shunjie Chen , Ying Wang , Early oral nutritional supplement improves COVID-19 outcomes among hospitalized older patients during the omicron wave, Nutrition (2023), doi:
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ONS use among 1181 older patients with COVID-19 was retrospectively studied.
ONS use was associated with a lower risk of in-hospital death.
Early ONS could also reduce hospital length of stay and days of viral clearance.
Timely nutritional support is important for COVID-19 geriatrics.
Early oral nutritional supplement improves COVID-19 outcomes among hospitalized older patients
during the omicron wave
Ying Chen1#, Yinfan Wu1#, Wei Ran1, Jingjue Yuan1, Zhangwei Yang2, Shunjie Chen2*, Ying Wang1*
Department of Clinical Nutrition, Shanghai Fourth People’s Hospital, School of Medicine, Tongji
University, Shanghai, 200434, China
Department of Medical Administration, Shanghai Fourth People’s Hospital, School of Medicine, Tongji
University, Shanghai, 200434, China
These authors contributed equally to this work.
Shunjie Chen, Ph.D. E-mail: firstname.lastname@example.org.
Ying Wang, Ph.D. E-mail: email@example.com;
Background: The effect of and optimal timing for initiating oral nutritional supplement (ONS) on
hospitalized older patients with the Omicron variant infection remain unclear.
Methods: We collected data from confirmed COVID-19 patients between April 2022 to June 2022 at
Shanghai Fourth People’s Hospital, one of the designated medical centers for COVID-19 in Shanghai,
China. Patients were identified as ONS users or non-ONS users, and the former was further defined as
early ONS (ONS initiated within 48h from hospital admission), and late ONS (ONS initiated after 48 h)
users. We conducted a retrospective cohort design as primary analysis and a case-control design as
sensitivity analysis to explore the associations between ONS and clinical outcomes.
Results: A total of 1181 hospitalized patients ≥60 years old were included in our study. The mean age of
the entire cohort was 78.0, and most patients were female (57.7%). The mortalities after PSM were 1.2%
and 4.3% in the ONS group and non-ONS groups, respectively (P = 0.032). Subgroup analysis results
showed that patients with early-ONS had significantly shorter hospital..
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