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All Studies   Meta Analysis    Recent:   

The association between COVID-19 vaccination and confirmed patients with hospitalization in Omicron era: A retrospective study

Chang et al., Medicine, doi:10.1097/MD.0000000000036777
Dec 2023  
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Mortality -185% Improvement Relative Risk Remdesivir for COVID-19  Chang et al.  LATE TREATMENT Is late treatment with remdesivir beneficial for COVID-19? Retrospective 209 patients in Taiwan Higher mortality with remdesivir (p=0.043) c19early.org Chang et al., Medicine, December 2023 Favorsremdesivir Favorscontrol 0 0.5 1 1.5 2+
Retrospective 209 hospitalized COVID-19 patients in Taiwan showing higher mortality with a 5-day course of remdesivir compared to other antivirals or no antiviral treatment in multivariable analysis. Adjustments include qSOFA and CCI, with the adjusted result decreasing risk by 3x, however adjustment may not fully account for confounding by severity.
Gérard, Zhou, Wu, Kamo, Choi show significantly increased risk of acute kidney injury with remdesivir.
risk of death, 184.7% higher, OR 2.85, p = 0.04, treatment 81, control 81, adjusted per study, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chang et al., 29 Dec 2023, retrospective, Taiwan, peer-reviewed, 2 authors.
This PaperRemdesivirAll
The association between COVID-19 vaccination and confirmed patients with hospitalization in Omicron era A retrospective study
MD Ming-Hung Chang, PhD Kuang-Ming Liao
doi:10.1097/MD.0000000000036777
With the emergence of Omicron variant of severe acute respiratory syndrome coronavirus 2, Taiwan has encountered the greatest coronavirus disease 2019 (COVID-19) pandemic since 2022 spring. We analyzed the characteristics, vaccinations, and outcomes of hospitalized COVID-19 patients quarantined in a dedicated ward. This retrospective study enrolled hospitalized COVID-19 patients in the dedicated wards of a district hospital in southern Taiwan from May 2022 to July 2022. We assessed in-hospital mortality, hospital length of stay (LOS), and dedicated ward LOS. Among 209 COVID-19 patients, the in-hospital mortality rates were 20.7% and 29.7% (P = .145) in patients with and without vaccination. A shorter dedicated ward LOS was noted in the vaccination group, with marginal statistical significance. Age, Charlson Comorbidity Index, and quick Sequential Organ Failure Assessment score were recognized as strong prognostic indicators for mortality in multivariable analysis. Vaccination demonstrated significant lower odds of death among relatively young populations in subgroup analysis. COVID-19 vaccination had significant efficacy in hospitalized COVID-19 patients in the relatively young group, and the effect may decline among individuals with advanced age and multiple comorbidities.
Author contributions Conceptualization
References
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Late treatment
is less effective
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