Efficacy of favipiravir in adults with mild COVID-19: a randomized, double-blind, multicentre, placebo-controlled clinical trial
Mohammad Bosaeed, Ahmad Alharbi, Ebrahim Mahmoud, Sanaa Alrehily, Mohannad Bahlaq, Zied Gaifer, Hanan Alturkistani, Khaled Alhagan, Saad Alshahrani, Ali Tolbah, Abrar Musattat, Maha Alanazi, Raniah Jaha, Khizra Sultana, Hajar Alqahtani, Kholoud Al Aamer, Saud Jaser, Abdulrahman Alsaedy, Ayoub Ahmad, Mohammed Abalkhail, Sameera Aljohani, Sultan Majed Al Jeraisy, Sultan Almaziad, Nahlah Albaalharith, Khaled Alabdulkareem, Abdulmajeed Alshowair, Naif Khalaf Alharbi, Fahad Alrabiah, Majid Alshamrani, Omar Aldibasi, Ahmed Alaskar
Clinical Microbiology and Infection, doi:10.1016/j.cmi.2021.12.026
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clinical/microbiological benefits of re-purposing antiviral therapy, particularly favipiravir, for SARS-CoV-2 infections. In conclusion, this randomized double-blinded placebo-controlled clinical trial found no clinical/virological benefit in treating mild COVID-19 patients with favipiravir. The trial result may influence decisions to remove favipiravir from national protocols for COVID-19 treatment.
Transparency declaration All authors declare no conflict of interests.
Author Contributions: Bosaeed M, Alharbi A, Mahmoud E, and Abalkhail M jointly formed the study concept and design,. All authors critically revised the report and approved the final version to be submitted for publication. The corresponding author confirms that he had full access to all the data in the study and had final responsibility for the decision to submit for publication Funding: This work was supported by King Abdullah International Medical Research Center, Saudi Arabia. Protocol No.RC20/220/R. The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. All the authors have full access to all the data in the study and had final responsibility for the decision to submit for publication. The study Statistical Analysis Plan is available with this publication as part of the supplementary material. Individual participant data are..
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