Tiprelestat for treatment of hospitalized COVID-19: results of the double-blind randomized placebo-controlled COMCOVID trial

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Hans-Heinrich Henneicke-von Zepelin and Oliver Wiedow are employees of the sponsor of this clinical trial." }, { "group": { "label": "Ethical approval", "name": "EthicsHeading" }, "name": "Ethics", "order": 3, "value": "The study was conducted in accordance with the Declaration of Helsinki on Ethical Principles for Medical Research Involving Human Subjects adopted by the General Assembly of the World Medical Association [\n \n ]. The planning and conduct of this clinical trial followed the national laws of Germany, the principles and guidelines for good clinical practice (GCP) laid down in Directives 2001/20/EC [\n \n ] and 2005/28/EC [\n \n ] of the European Parliament and the International Conference on Harmonisation (ICH) Guideline for Good Clinical Practice [\n \n ]. The trial protocol and other study-relevant documents were submitted for review and approved by the Ethics Commission at the RWTH Aachen Faculty of Medicine in Aachen, Germany (EK 197/22, September 2022). The protocol was also reviewed and approved by the national competent authority in Germany (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), finally in February 2023 (trial registration: EudraCT 2022–000714-33, DRKS00031463) [\n \n ,\n \n ]." } ], "author": [ { "affiliation": [], "family": "Bergs", "given": "Ingmar", "sequence": "first" }, { "affiliation": [], "family": "Budweiser", "given": "Stephan", "sequence": "additional" }, { "ORCID": "https://orcid.org/0000-0001-5473-5887", "affiliation": [], "authenticated-orcid": false, "family": "Henneicke-von Zepelin", "given": "Hans-Heinrich", "sequence": "additional" }, { "affiliation": [], "family": "Kelm", "given": "Hagen", "sequence": "additional" }, { "affiliation": [], "family": "Bollmann", "given": "Tom", "sequence": "additional" }, { "affiliation": [], "family": "Tebbe", "given": "Johannes-Josef", "sequence": "additional" }, { "affiliation": [], "family": "Sorichter", "given": "Stephan", "sequence": "additional" }, { "affiliation": [], "family": "Lüth", "given": "Stefan", "sequence": "additional" }, { "affiliation": [], "family": "Walterspacher", "given": "Stephan", "sequence": "additional" }, { "affiliation": [], "family": "Wege", "given": "Henning", "sequence": "additional" }, { "affiliation": [], "family": "Wiedow", "given": "Oliver", "sequence": "additional" }, { "affiliation": [], "family": "Dreher", "given": "Michael", "sequence": "additional" } ], "container-title": "Advances in Therapy", "container-title-short": "Adv Ther", "content-domain": { "crossmark-restriction": false, "domain": [ "link.springer.com" ] }, "created": { "date-parts": [ [ 2025, 9, 16 ] ], "date-time": "2025-09-16T06:14:04Z", "timestamp": 1758003244000 }, "deposited": { "date-parts": [ [ 2026, 1, 19 ] ], "date-time": "2026-01-19T11:24:40Z", "timestamp": 1768821880000 }, "funder": [ { "DOI": "10.13039/501100002347", "award": [ "16LW0151" ], "award-info": [ { "award-number": [ "16LW0151" ] } ], "doi-asserted-by": "crossref", "id": [ { "asserted-by": "crossref", "id": "10.13039/501100002347", "id-type": "DOI" } ], "name": "Federal Ministry of Research, Technology and Space" }, { "name": "Universitätsklinikum RWTH Aachen" } ], "indexed": { "date-parts": [ [ 2026, 1, 21 ] ], "date-time": "2026-01-21T19:36:14Z", "timestamp": 1769024174065, "version": "3.49.0" }, "is-referenced-by-count": 0, "issue": "11", "issued": { "date-parts": [ [ 2025, 9, 16 ] ] }, "journal-issue": { "issue": "11", "published-print": { "date-parts": [ [ 2025, 11 ] ] } }, "language": "en", "license": [ { "URL": "https://creativecommons.org/licenses/by-nc/4.0", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2025, 9, 16 ] ], "date-time": "2025-09-16T00:00:00Z", "timestamp": 1757980800000 } }, { "URL": "https://creativecommons.org/licenses/by-nc/4.0", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2025, 9, 16 ] ], "date-time": "2025-09-16T00:00:00Z", "timestamp": 1757980800000 } } ], "link": [ { "URL": "https://link.springer.com/content/pdf/10.1007/s12325-025-03362-w.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/article/10.1007/s12325-025-03362-w", "content-type": "text/html", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/content/pdf/10.1007/s12325-025-03362-w.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "297", "original-title": [], "page": "5683-5695", "prefix": "10.1007", "published": { "date-parts": [ [ 2025, 9, 16 ] ] }, "published-online": { "date-parts": [ [ 2025, 9, 16 ] ] }, "published-print": { "date-parts": [ [ 2025, 11 ] ] }, "publisher": "Springer Science and Business Media LLC", "reference": [ { "key": "3362_CR1", "unstructured": "World Health Organization (WHO): WHO Coronavirus (COVID-19) Dashboard. https://COVID-19.who.int/" }, { "DOI": "10.3390/tropicalmed7030051", "author": "G Chae", "doi-asserted-by": "publisher", "journal-title": "Trop Med Infect Dis", "key": "3362_CR2", "unstructured": "Chae G, et al. 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