Significance of 1,25-Dihydroxyvitamin D3 on Overall Mortality in Peritoneal Dialysis Patients with COVID-19
Marko Baralić, Dragana Robajac, Ana Penezić, Voin Brković, Nikola Gligorijević, Ana Bontić, Jelena Pavlović, Jelena Nikolić, Goran Miljuš, Zorana Dobrijević, Miloš Šunderić, Lucia Pažitná, Jaroslav Katrlík, Olgica Nedić, Mirjana Laušević
Nutrients, doi:10.3390/nu15092050
In previous publications, we pointed out the importance of mannosylation of fibrinogen for the development of cardiovascular complications and fucosylation as a predictor of peritoneal membrane dysfunction in patients on peritoneal dialysis (PD). After a follow-up period of 30 months from the onset of the COVID-19 pandemic, we evaluated the significance of 1,25-dihydroxyvitamin D 3 (calcitriol) therapy, primary disease, biochemical and hematologic analyzes, and previously performed glycan analysis by lectin-based microarray as predictors of mortality in this patient group. After univariate Cox regression analysis, diabetes mellitus (DM) and calcitriol therapy were found to be potential predictors of mortality. Additional multivariate Cox regression analysis confirmed that only DM was a predictor of mortality. Nevertheless, the use of calcitriol in therapy significantly reduced mortality in this patient group, as shown by the Kaplan-Meier survival curve. The presence of DM as a concomitant disease proved to be a strong predictor of fatal outcome in PD patients infected with SARS-CoV-2. This is the first study to indicate the importance and beneficial effect of calcitriol therapy on survival in PD patients with COVID-19 infection. In addition, this study points to the possibility that adverse thrombogenic events observed in PD patients during the pandemic may be caused by aberrant fibrinogen glycosylation.
Informed Consent Statement: Informed consent was obtained from all subjects involved in the study.
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'abstract': '<jats:p>In previous publications, we pointed out the importance of mannosylation of '
'fibrinogen for the development of cardiovascular complications and fucosylation as a '
'predictor of peritoneal membrane dysfunction in patients on peritoneal dialysis (PD). After a '
'follow-up period of 30 months from the onset of the COVID-19 pandemic, we evaluated the '
'significance of 1,25-dihydroxyvitamin D3 (calcitriol) therapy, primary disease, biochemical '
'and hematologic analyzes, and previously performed glycan analysis by lectin-based microarray '
'as predictors of mortality in this patient group. After univariate Cox regression analysis, '
'diabetes mellitus (DM) and calcitriol therapy were found to be potential predictors of '
'mortality. Additional multivariate Cox regression analysis confirmed that only DM was a '
'predictor of mortality. Nevertheless, the use of calcitriol in therapy significantly reduced '
'mortality in this patient group, as shown by the Kaplan–Meier survival curve. The presence of '
'DM as a concomitant disease proved to be a strong predictor of fatal outcome in PD patients '
'infected with SARS-CoV-2. This is the first study to indicate the importance and beneficial '
'effect of calcitriol therapy on survival in PD patients with COVID-19 infection. In addition, '
'this study points to the possibility that adverse thrombogenic events observed in PD patients '
'during the pandemic may be caused by aberrant fibrinogen glycosylation.</jats:p>',
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