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@CovidAnalysis
All Studies   All Outcomes    Recent:   

Industry Alliance Platform Trial to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalized Patients

Amgen, NCT04590586, COMMUNITY, NCT04590586
Apr 2022  
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Mortality -7% Improvement Relative Risk Improvement 10% Discharge 24% Recovery -9% Lanadelumab  COMMUNITY  LATE TREATMENT  DB RCT Is late treatment with lanadelumab beneficial for COVID-19? Double-blind RCT 515 patients in the USA Higher discharge with lanadelumab (not stat. sig., p=0.57) c19early.org Amgen, NCT04590586, April 2022 Favorslanadelumab Favorscontrol 0 0.5 1 1.5 2+
RCT 55 hospitalized patients showing no significant difference with lanadelumab treatment.
Important missing comments or errors? Let us know.
Study covers apremilast and lanadelumab.
risk of death, 6.7% higher, RR 1.07, p = 1.00, treatment 8 of 25 (32.0%), control 9 of 30 (30.0%).
risk of no improvement, 10.0% lower, RR 0.90, p = 0.79, treatment 9 of 25 (36.0%), control 12 of 30 (40.0%), NNT 25.
risk of no hospital discharge, 23.6% lower, RR 0.76, p = 0.57, treatment 7 of 25 (28.0%), control 11 of 30 (36.7%), NNT 12.
risk of no recovery, 9.1% higher, RR 1.09, p = 1.00, treatment 10 of 25 (40.0%), control 11 of 30 (36.7%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Amgen et al., 7 Apr 2022, Double Blind Randomized Controlled Trial, placebo-controlled, USA, preprint, 1 author, trial NCT04590586 (history) (COMMUNITY). Contact: medinfo@amgen.com.
This PaperLanadelumabAll
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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