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Molnupiravir Inhibits Replication of the Emerging SARS-CoV-2 Variants of Concern in a Hamster Infection Model

Abdelnabi et al., The Journal of Infectious Diseases, doi:10.1093/infdis/jiab361
Jul 2021  
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Hamster study showing molnupiravir effective against the original, B.1.1.7, and B.1.351 variants.
Potential risks include the creation of dangerous variants, and mutagenicity, carcinogenicity, teratogenicity, and embryotoxicity1-10. Multiple analyses have identified variants potentially created by molnupiravir11-14.
Abdelnabi et al., 9 Jul 2021, peer-reviewed, 6 authors.
This PaperMolnupiravirAll
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Currently available monoclonal antibodies and ' 'vaccines appear to have reduced efficacy against some of these VoCs. Antivirals targeting ' 'conserved proteins of SARS-CoV-2 are unlikely to be affected by mutations arising in VoCs and ' 'should therefore be effective against emerging variants. We here investigate the efficacy of ' 'molnupiravir, currently in phase 2 clinical trials, in hamsters infected with Wuhan strain or ' 'B.1.1.7 and B.1.351 variants. Molnupiravir proved to be effective against infections with ' 'each of the variants and therefore may have potential combating current and future emerging ' 'VoCs.</jats:p>', 'DOI': '10.1093/infdis/jiab361', 'type': 'journal-article', 'created': {'date-parts': [[2021, 7, 8]], 'date-time': '2021-07-08T19:13:00Z', 'timestamp': 1625771580000}, 'page': '749-753', 'source': 'Crossref', 'is-referenced-by-count': 99, 'title': 'Molnupiravir Inhibits Replication of the Emerging SARS-CoV-2 Variants of Concern in a Hamster ' 'Infection Model', 'prefix': '10.1093', 'volume': '224', 'author': [ { 'given': 'Rana', 'family': 'Abdelnabi', 'sequence': 'first', 'affiliation': [ { 'name': 'Laboratory of Virology and Chemotherapy, Department of ' 'Microbiology, Immunology and Transplantation, Rega Institute for ' 'Medical Research, Katholieke Universiteit Leuven, Leuven, ' 'Belgium'}]}, { 'given': 'Caroline S', 'family': 'Foo', 'sequence': 'additional', 'affiliation': [ { 'name': 'Laboratory of Virology and Chemotherapy, Department of ' 'Microbiology, Immunology and Transplantation, Rega Institute for ' 'Medical Research, Katholieke Universiteit Leuven, Leuven, ' 'Belgium'}]}, { 'given': 'Steven', 'family': 'De Jonghe', 'sequence': 'additional', 'affiliation': [ { 'name': 'Laboratory of Virology and Chemotherapy, Department of ' 'Microbiology, Immunology and Transplantation, Rega Institute for ' 'Medical Research, Katholieke Universiteit Leuven, Leuven, ' 'Belgium'}]}, { 'ORCID': 'http://orcid.org/0000-0001-9118-8608', 'authenticated-orcid': False, 'given': 'Piet', 'family': 'Maes', 'sequence': 'additional', 'affiliation': [ { 'name': 'Laboratory of Clinical and Epidemiological Virology, Department ' 'of Microbiology, Immunology and Transplantation, Rega Institute, ' 'Katholieke Universiteit Leuven, Leuven, Belgium'}, {'name': 'Zoonotic Infectious Diseases Unit, KU Leuven, Leuven, Belgium'}]}, { 'given': 'Birgit', 'family': 'Weynand', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Imaging and Pathology, Division of Translational ' 'Cell and Tissue Research, Katholieke Universiteit Leuven, ' 'Leuven, Belgium'}]}, { 'given': 'Johan', 'family': 'Neyts', 'sequence': 'additional', 'affiliation': [ { 'name': 'Laboratory of Virology and Chemotherapy, Department of ' 'Microbiology, Immunology and Transplantation, Rega Institute for ' 'Medical Research, Katholieke Universiteit Leuven, Leuven, ' 'Belgium'}, {'name': 'Global Virus Network, Baltimore, Maryland, USA'}]}], 'member': '286', 'published-online': {'date-parts': [[2021, 7, 9]]}, 'reference': [ { 'key': '2021090109221259500_CIT0001', 'doi-asserted-by': 'crossref', 'first-page': '727', 'DOI': '10.1056/NEJMoa2001017', 'article-title': 'A novel coronavirus from patients with pneumonia in China, 2019', 'volume': '382', 'author': 'Zhu', 'year': '2020', 'journal-title': 'N Engl J Med'}, { 'key': '2021090109221259500_CIT0002', 'doi-asserted-by': 'crossref', 'first-page': '508', 'DOI': 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'journal-title': 'Nature'}, { 'key': '2021090109221259500_CIT0009', 'doi-asserted-by': 'crossref', 'first-page': '11', 'DOI': '10.1038/s41564-020-00835-2', 'article-title': 'Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 ' 'blocks SARS-CoV-2 transmission in ferrets', 'volume': '6', 'author': 'Cox', 'year': '2021', 'journal-title': 'Nat Microbiol'}, { 'key': '2021090109221259500_CIT0010', 'doi-asserted-by': 'crossref', 'first-page': 'e02428-20', 'DOI': '10.1128/AAC.02428-20', 'article-title': 'Human safety, tolerability, and pharmacokinetics of molnupiravir, a ' 'novel broad-spectrum oral antiviral agent with activity against ' 'SARS-CoV-2', 'volume': '65', 'author': 'Painter', 'year': '2021', 'journal-title': 'Antimicrob Agents Chemother'}, { 'key': '2021090109221259500_CIT0011', 'article-title': 'Reduction in infectious SARS-CoV-2 in treatment study of COVID-19 with ' 'molnupiravir', 'author': 'Painter'}, { 'key': '2021090109221259500_CIT0012', 'doi-asserted-by': 'crossref', 'first-page': '103403', 'DOI': '10.1016/j.ebiom.2021.103403', 'article-title': 'Comparing infectivity and virulence of emerging SARS-CoV-2 variants in ' 'Syrian hamsters', 'volume': '68', 'author': 'Abdelnabi', 'year': '2021', 'journal-title': 'EBioMedicine'}, { 'key': '2021090109221259500_CIT0013', 'doi-asserted-by': 'crossref', 'first-page': '130', 'DOI': '10.1038/s41586-021-03398-2', 'article-title': 'Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7', 'volume': '593', 'author': 'Wang', 'year': '2021', 'journal-title': 'Nature'}, { 'key': '2021090109221259500_CIT0014', 'doi-asserted-by': 'crossref', 'first-page': '329', 'DOI': '10.1126/science.371.6527.329', 'article-title': 'New mutations raise specter of ‘immune escape’', 'volume': '371', 'author': 'Kupferschmidt', 'year': '2021', 'journal-title': 'Science'}, { 'key': '2021090109221259500_CIT0015', 'doi-asserted-by': 'crossref', 'first-page': '82', 'DOI': '10.1016/j.coviro.2021.03.010', 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