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All Studies   Meta Analysis       

Azvudine efficacy in reducing mortality in COVID-19 patients

Zhong et al., European Journal of Medical Research, doi:10.1186/s40001-024-02220-9
Dec 2024  
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Mortality, IPTW, day 28 35% Improvement Relative Risk Mortality, PSM, day 28 43% Mortality, IPTW, day 14 52% Mortality, PSM, day 14 56% Mortality, IPTW, day 7 87% Mortality, PSM, day 7 88% Azvudine for COVID-19  Zhong et al.  LATE TREATMENT Is late treatment with azvudine beneficial for COVID-19? Retrospective 2,862 patients in China (December 2022 - March 2023) No significant difference in mortality c19early.org Zhong et al., European J. Medical Rese.., Dec 2024 Favorsazvudine Favorscontrol 0 0.5 1 1.5 2+
Azvudine for COVID-19
44th treatment shown to reduce risk in July 2023, now with p = 0.0000013 from 28 studies.
Lower risk for mortality, progression, and viral clearance.
No treatment is 100% effective. Protocols combine treatments.
5,200+ studies for 112 treatments. c19early.org
Retrospective 2,862 hospitalized COVID-19 patients in China showing lower mortality with azvudine treatment, with greater efficacy for severe and critical patients.
risk of death, 35.0% lower, HR 0.65, p = 0.048, treatment 1,490, control 1,372, propensity score weighting, day 28.
risk of death, 43.0% lower, HR 0.57, p = 0.003, treatment 920, control 920, propensity score matching, day 28.
risk of death, 52.0% lower, HR 0.48, p = 0.048, treatment 1,490, control 1,372, propensity score weighting, day 14.
risk of death, 56.0% lower, HR 0.44, p = 0.003, treatment 920, control 920, propensity score matching, day 14.
risk of death, 87.0% lower, HR 0.13, p = 0.048, treatment 1,490, control 1,372, propensity score weighting, day 7.
risk of death, 88.0% lower, HR 0.12, p = 0.003, treatment 920, control 920, propensity score matching, day 7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Zhong et al., 26 Dec 2024, retrospective, China, peer-reviewed, 7 authors, study period 1 December, 2022 - 31 March, 2023. Contact: xianfa13579@163.com.
This PaperAzvudineAll
Azvudine efficacy in reducing mortality in COVID-19 patients
Zhen Zhong, Xiao-Feng Liu, Xiao-Zhong Zhou, Jia-Ning Zhong, Li-Cheng Zhou, Rong Li, Xian-Fa Liu
European Journal of Medical Research, doi:10.1186/s40001-024-02220-9
Background Several therapeutic drugs have been authorized for the treatment of patients with Coronavirus disease 2019 . However, further research on the mechanisms of action, efficacy, and target populations of these novel therapeutic drugs are necessary. This study included mild, moderate, severe, and critical COVID-19 patients to evaluate azvudine's effectiveness across different severity levels. Methods We conducted a retrospective cohort study of patients with COVID-19 admitted to our hospital from December 1, 2022, to March 31, 2023. Patients were divided into retrospective cohorts receiving azvudine antiviral therapy and standard treatment, and were followed-up for up to 28 days. Results Prior to data processing, azvudine treatment was associated with reduced mortality rates at 7 days (1.09/1000 persons vs. 5.06/1000 persons, P < 0.001) and 14 days (3.35/1000 persons vs. 5.65/1000 persons, P = 0.001). After propensity score matching, a decrease in mortality rates at 7 days (0.8/1000 persons vs. 6.29/1000 persons, P < 0.001), 14 days (3.42/1000 persons vs. 7.26/1000 persons, P < 0.001), and 28 days (4.33/1000 persons vs. 7.29/1000 persons, P = 0.003) were observed following azvudine treatment. After inverse probability of treatment weighting adjustment, the results were consistent with propensity score matching. In the clinical subgroup analysis, azvudine treatment intervention significantly reduced the 7-day (2.49/1000 persons vs. 14.59/1000 persons, P = 0.001 and 11.36/1000 persons vs. 66.99/1000 persons, P < 0.001), 14-day (5.22/1000 persons vs. 17.36/1000 persons, P < 0.001 and 17.08/1000 persons vs. 51.72/1000 persons, P = 0.002), and 28-day (7.58/1000 persons vs. 16.02/1000 persons, P = 0.014 and 20.43/1000 persons vs. 46.51/1000 persons, P = 0.008) mortality rates in hospitalized patients with severe and critical COVID-19. Conclusions The study suggests that in hospitalized patients with COVID-19, azvudine treatment significantly reduces patient mortality rates in hospitalized COVID-19 infections, wherein the effects are more pronounced in severe and critical patients.
Abbreviations Supplementary Information The online version contains supplementary material available at https:// doi . org/ 10. 1186/ s40001-024-02220-9. Additional file 1 Author contributions XianfaL and JZ designed the experiments. XiaoL was responsible for clinical assessment of patients. LZ, XZ, LR, and ZZ collected the data. JZ was responsible for data management. JZ and ZZ conducted the statistical analysis. This article was written by ZZ, and reviewed by XianfaL. All the authors have reviewed and approved of the final manuscript. Declarations Ethics approval and consent to participate There was no direct patient involvement in the conception, design, or implementation of this study. The requirement for patient consent was waived for Competing interests The authors declare no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
References
Bernal, Molnupiravir for oral treatment of covid-19 in nonhospitalized patients, N Engl J Med, doi:10.1056/NEJMoa2116044
Bertuccio, The impact of early therapies for COVID-19 on death, hospitalization and persisting symptoms: a retrospective study, Infection, doi:10.1007/s15010-023-02028-5
Chang, 4'-modified nucleosides for antiviral drug discovery: achievements and perspectives, Acc Chem Res, doi:10.1021/acs.accounts.1c00697
Da Silva, Serial viral load analysis by DDPCR to evaluate FNC efficacy and safety in the treatment of mild cases of COVID-19, Front Med, doi:10.3389/fmed.2023.1143485
Deng, Real-world effectiveness of Azvudine versus nirmatrelvirritonavir in hospitalized patients with COVID-19: a retrospective cohort study, J Med Virol, doi:10.1002/jmv.28756
Gentile, Nirmatrelvir/ritonavir and molnupiravir in the treatment of mild/moderate COVID-19: results of a real-life study, Vaccines, doi:10.3390/vaccines10101731
Hammond, Oral nirmatrelvir for high-risk, nonhospitalized adults with Covid-19, N Engl J Med, doi:10.1056/NEJMoa2118542
Hashemian, Paxlovid (Nirmatrelvir/Ritonavir): a new approach to Covid-19 therapy?, Biomed Pharmacother Biomedecine & Pharmacotherapie, doi:10.1016/j.biopha.2023.114367
Kabinger, Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis, Nat Struct Mol Biol, doi:10.1038/s41594-021-00651-0
Lui, Analysis of all-cause hospitalization and death among nonhospitalized patients with type 2 diabetes and SARS-CoV-2 infection treated with molnupiravir or nirmatrelvir-ritonavir during the omicron wave in Hong Kong, JAMA Netw Open, doi:10.1001/jamanetworkopen.2023.14393
Morris, Lee, Nirmatrelvir for nonhospitalized adults with Covid-19, N Engl J Med, doi:10.1056/NEJMc2206277
Ren, A Randomized, open-label, controlled clinical trial of azvudine tablets in the treatment of mild and common COVID-19, a pilot study, Adv Sci, doi:10.1002/advs.202001435
Sun, Oral Azvudine for hospitalised patients with COVID-19 and pre-existing conditions: a retrospective cohort study, EClinicalMedicine, doi:10.1016/j.eclinm.2023.101981
Wang, Effectiveness of azvudine in reducing mortality of COVID-19 patients: a systematic review and meta-analysis, Virol J, doi:10.1186/s12985-024-02316-y
Wang, Efficacy and safety of azvudine for the treatment of COVID-19: a multicenter, open-label, randomized controlled trial, J Infect, doi:10.1016/j.jinf.2021.05.008
Wong, Real-world effectiveness of molnupiravir and nirmatrelvir plus ritonavir against mortality, hospitalisation, and in-hospital outcomes among community-dwelling, ambulatory patients with confirmed SARS-CoV-2 infection during the omicron wave in Hong Kong: an observational study, Lancet, doi:10.1016/S0140-6736(22)01586-0
Xie, Molnupiravir and risk of post-acute sequelae of covid-19: cohort study, BMJ, doi:10.1136/bmj-2022-074572
Xie, Wang, Xu, Effectiveness and safety of azvudine versus nirmatrelvir-ritonavir in adult patients infected with COVID-19 omicron strains: a retrospective study in Beijing, Sci Rep, doi:10.1038/s41598-024-74502-5
Yang, Rao, Structural biology of SARS-CoV-2 and implications for therapeutic development, Nat Rev Microbiol, doi:10.1038/s41579-021-00630-8
Yu, Chang, Azvudine (FNC): a promising clinical candidate for COVID-19 treatment, Signal Transduction Targeted Therapy, doi:10.1038/s41392-020-00351-z
Zhang, Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients, Signal Transduct Target Ther, doi:10.1038/s41392-021-00835-6
Zhao, Is azvudine comparable to nirmatrelvir-ritonavir in realworld efficacy and safety for hospitalized patients with COVID-19? A retrospective cohort study, Infect Dis Therapy, doi:10.1007/s40121-023-00845-7
Zhou, β-d-N4-hydroxycytidine Inhibits SARS-CoV-2 through lethal mutagenesis but is also mutagenic to Mammalian cells, J Infect Dis, doi:10.1093/infdis/jiab247
Zhu, Efficacy and safety evaluation of Azvudine in the prospective treatment of COVID-19 based on four phase III clinical trials, Front Pharmacol, doi:10.3389/fphar.2023.1228548
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' 'https://doi.org/10.1007/s40121-023-00845-7.', 'journal-title': 'Infect Dis Therapy'}, { 'key': '2220_CR21', 'doi-asserted-by': 'publisher', 'first-page': '1143485', 'DOI': '10.3389/fmed.2023.1143485', 'volume': '10', 'author': 'RM da Silva', 'year': '2023', 'unstructured': 'da Silva RM, et al. Serial viral load analysis by DDPCR to evaluate FNC ' 'efficacy and safety in the treatment of mild cases of COVID-19. Front ' 'Med. 2023;10:1143485. https://doi.org/10.3389/fmed.2023.1143485.', 'journal-title': 'Front Med'}, { 'issue': '4', 'key': '2220_CR22', 'doi-asserted-by': 'publisher', 'first-page': 'e28756', 'DOI': '10.1002/jmv.28756', 'volume': '95', 'author': 'G Deng', 'year': '2023', 'unstructured': 'Deng G, et al. Real-world effectiveness of Azvudine versus ' 'nirmatrelvir-ritonavir in hospitalized patients with COVID-19: a ' 'retrospective cohort study. J Med Virol. 2023;95(4):e28756. ' 'https://doi.org/10.1002/jmv.28756.', 'journal-title': 'J Med Virol'}, { 'issue': '1', 'key': '2220_CR23', 'doi-asserted-by': 'publisher', 'first-page': '46', 'DOI': '10.1186/s12985-024-02316-y', 'volume': '21', 'author': 'Y Wang', 'year': '2024', 'unstructured': 'Wang Y, et al. Effectiveness of azvudine in reducing mortality of ' 'COVID-19 patients: a systematic review and meta-analysis. Virol J. ' '2024;21(1):46. https://doi.org/10.1186/s12985-024-02316-y.', 'journal-title': 'Virol J'}, { 'issue': '4', 'key': '2220_CR24', 'doi-asserted-by': 'publisher', 'first-page': '565', 'DOI': '10.1021/acs.accounts.1c00697', 'volume': '55', 'author': 'J Chang', 'year': '2022', 'unstructured': 'Chang J. 4’-modified nucleosides for antiviral drug discovery: ' 'achievements and perspectives. Acc Chem Res. 2022;55(4):565–78. ' 'https://doi.org/10.1021/acs.accounts.1c00697.', 'journal-title': 'Acc Chem Res'}, { 'key': '2220_CR25', 'doi-asserted-by': 'publisher', 'unstructured': 'Wang, Yaqi, et al. Efficacy and safety of azvudine for the treatment of ' 'COVID-19: a multicenter, open-label, randomized controlled trial. J ' 'Infect. 2021;83(3): 346–355. https://doi.org/10.1016/j.jinf.2021.05.008.', 'DOI': '10.1016/j.jinf.2021.05.008'}], 'container-title': 'European Journal of Medical Research', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1186/s40001-024-02220-9.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1186/s40001-024-02220-9/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1186/s40001-024-02220-9.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 12, 26]], 'date-time': '2024-12-26T09:05:31Z', 'timestamp': 1735203931000}, 'score': 1, 'resource': { 'primary': { 'URL': 'https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-024-02220-9'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 12, 26]]}, 'references-count': 25, 'journal-issue': {'issue': '1', 'published-online': {'date-parts': [[2024, 12]]}}, 'alternative-id': ['2220'], 'URL': 'http://dx.doi.org/10.1186/s40001-024-02220-9', 'relation': {}, 'ISSN': ['2047-783X'], 'subject': [], 'container-title-short': 'Eur J Med Res', 'published': {'date-parts': [[2024, 12, 26]]}, 'assertion': [ { 'value': '24 March 2024', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '14 December 2024', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '26 December 2024', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, {'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Declarations'}}, { 'value': 'There was no direct patient involvement in the conception, design, or ' 'implementation of this study. The requirement for patient consent was waived ' 'for this retrospective study, which utilized data from electronic medical ' 'records. This study was approved by the Ethics Committee of the First ' 'Affiliated Hospital of the Gannan Medical University Hospital (LLSL-2024065).', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethics approval and consent to participate'}}, { 'value': 'Not applicable.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent for publication'}}, { 'value': 'The authors declare no competing interests.', 'order': 4, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '625'}
Late treatment
is less effective
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