Conv. Plasma
Nigella Sativa

All azvudine studies
Meta analysis
study COVID-19 treatment researchAzvudineAzvudine (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Effectiveness of azvudine in reducing mortality of COVID-19 patients: a systematic review and meta-analysis

Wang et al., Virology Journal, doi:10.1186/s12985-024-02316-y
Feb 2024  
  Source   PDF   All Studies   Meta AnalysisMeta
Azvudine for COVID-19
41st treatment shown to reduce risk in July 2023
*, now known with p = 0.00014 from 18 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Systematic review and meta-analysis of 17 studies showing significantly lower mortality with azvudine compared to no antiviral treatment in COVID-19 patients. The mortality benefit was seen in both mild/moderate and severe disease, as well as in patients over 65 years old. There was no significant difference found between azvudine and control groups for ICU admission, invasive ventilation, or adverse events.
2 meta analyses show significant improvements with azvudine for mortality Wang, Zheng, mechanical ventilation Zheng, improvement Zheng, and viral clearance Zheng.
Currently there are 18 azvudine for COVID-19 studies, showing 34% lower mortality [20‑46%], 31% lower ventilation [7‑48%], 47% lower ICU admission [5‑70%], and 43% lower hospitalization [-85‑82%].
Wang et al., 23 Feb 2024, peer-reviewed, 13 authors. Contact:
This PaperAzvudineAll
Effectiveness of azvudine in reducing mortality of COVID-19 patients: a systematic review and meta-analysis
Yaqi Wang, Huaiya Xie, Luo Wang, Junping Fan, Ying Zhang, Siqi Pan, Wangji Zhou, Qiaoling Chen, Xueqi Liu, Aohua Wu, Hong Zhang, Jinglan Wang, Xinlun Tian
Virology Journal, doi:10.1186/s12985-024-02316-y
Background Azvudine has been approved for the treatment of coronavirus disease 2019 patients in China, and this meta-analysis aims to illustrate the safety of azvudine and its effectiveness in reducing mortality. Methods PubMed, Embase, Web of science, Cochrane Library and the Epistemonikos COVID-19 Living Overview of Evidence database (L.OVE) were searched to aggregate currently published studies. Cochrane risk of bias tool and ROBINS-I tool were used to assess the risk of bias of randomized controlled study and cohort study respectively. Odds radios (ORs) with 95% confidence interval (CIs) were combined for dichotomous variables. Publication bias was assessed by Egger's test and funnel plots. Results A total of 184 articles were retrieved from the included databases and 17 studies were included into the final analysis. Pooled analysis showed that azvudine significantly reduced mortality risk in COVID-19 patients compared with controls (OR: 0.41, 95%CI 0.31-0.54, p < 0.001). Besides, either mild to moderate or severe COVID-19 patients could benefit from azvudine administration. There was no significant difference in the incidence of ICU admission (OR: 0.90, 95%CI 0.47-1.72, p = 0.74) and invasive ventilation (OR: 0.94, 95%CI 0.54-1.62, p = 0.82) between azvudine and control group. The incidence of adverse events was similar between azvudine and control (OR: 1.26, 95%CI 0.59-2.70, p = 0.56). Conclusions This meta-analysis suggests that azvudine could reduce the mortality risk of COVID-19 patients, and the safety of administration is acceptable.
Abbreviations Supplementary Information The online version contains supplementary material available at https://doi. org/10.1186/s12985-024-02316-y. Supplementary Material 1: Supplementary Declarations Ethics approval and consent to participate Not applicable. Consent for publication Not applicable. Competing interests The authors declare no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Amani, Amani, Efficacy and safety of nirmatrelvir/ritonavir (paxlovid) for COVID-19: a rapid review and meta-analysis, J Med Virol
Cabral, De Souza, Silva, Arruda, Cabral et al., Serial viral load analysis by Ddpcr to evaluate Fnc efficacy and safety in the treatment of moderate cases of Covid-19
Cheema, Jafar, Sohail, Shahid, Sahra et al., Nirmatrelvir-Ritonavir for the treatment of COVID-19 patients: a systematic review and meta-analysis, J Med Virol
Chen, Guo, Deng, Wang, Gao et al., Allcause mortality in moderate and severe COVID-19 patients with myocardial injury receiving versus not receiving azvudine: a propensity score-matched analysis, Cardiol Plus
Chen, Tian, Efficacy and safety of azvudine in patients with COVID-19: a systematic review and meta-analysis, Heliyon
Chen, Xu, Hong, Yang, Peng et al., Oral azvudine (FNC) tablets in patients infected with SARS-CoV-2 Omicron variant. A retrospective cohort study
Chu, Schwartz, Donnelly, Chuey, Soto et al., Comparison of home antigen testing with RT-PCR and viral culture during the course of SARS-CoV-2 infection, JAMA Intern Med
Da Silva, Cabral, De Souza, Arruda, Cabral et al., Serial viral load analysis by DDPCR to evaluate FNC efficacy and safety in the treatment of mild cases of COVID-19, Front Med
Deng, Li, Sun, Zhou, Xiao et al., Real-world effectiveness of azvudine versus nirmatrelvir-ritonavir in hospitalized patients with COVID-19: a retrospective cohort study, J Med Virol
Dian, Meng, Sun, Deng, Zeng, Azvudine versus paxlovid for oral treatment of COVID-19 in Chinese patients with pre-existing comorbidities, J Infect
Docherty, Harrison, Green, Hardwick, Pius et al., Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO clinical characterisation protocol: prospective observational cohort study, BMJ
Gao, Luo, Ren, Duan, Han et al., Antiviral effect of azvudine and nirmatrelvir-ritonavir among hospitalized patients with COVID-19, J Infect
Han, Han, Wang, Wang, Cui et al., Effectiveness and optimal timing of azvudine in COVID-19 patients: a multicenter retrospective study in Beijing
Higgins, Altman, Gøtzsche, Jüni, Moher et al., The Cochrane collaboration's tool for assessing risk of bias in randomised trials, BMJ
Keni, Alexander, Nayak, Mudgal, Nandakumar, COVID-19: emergence, spread, possible treatments, and global burden, Front Public Health
Lamontagne, Agarwal, Rochwerg, Siemieniuk, Agoritsas et al., A living WHO guideline on drugs for covid-19, BMJ
Lemaitre, Grégoire, Monchaud, Bouchet, Saint-Salvi et al., Management of drug-drug interactions with nirmatrelvir/ritonavir in patients treated for Covid-19: guidelines from the French society of pharmacology and therapeutics (SFPT), Therapie
Liberati, Altman, Tetzlaff, Mulrow, Gøtzsche et al., The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration, BMJ
Ren, Luo, Yu, Song, Liang et al., A randomized, open-label, controlled clinical trial of azvudine tablets in the treatment of mild and common COVID-19, a pilot study, Adv Sci
Shang, Fu, Geng, Zhang, Zhang et al., Azvudine therapy of common COVID-19 in hemodialysis patients, J Med Virol
Shao, Fan, Guo, Huang, Guo et al., Composite interventions on outcomes of severely and critically ill patients with COVID-19 in Shanghai, China, Microorganisms
Shen, Xiao, Sun, Li, Wu et al., Real-world effectiveness of azvudine in hospitalized patients with COVID-19: a retrospective cohort study, medRxiv
Sterne, Hernán, Reeves, Savović, Berkman et al., ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions, BMJ
Sun, Dian, Shen, Zeng, Chen et al., Oral azvudine for hospitalised patients with COVID-19 and pre-existing conditions: a retrospective cohort study, Eclinicalmedicine
Sun, Peng, Yu, Zhang, Liang et al., Mechanistic insight into antiretroviral potency of 2'-Deoxy-2'-β-fluoro-4'-azidocytidine (FNC) with a long-lasting effect on HIV-1 prevention, J Med Chem
Tian, Sun, Xu, Ye, The emergence and epidemic characteristics of the highly mutated SARS-CoV-2 Omicron variant, J Med Virol
Wong, Au, Lau, Lau, Cowling et al., Real-world effectiveness of early molnupiravir or nirmatrelvir-ritonavir in hospitalised patients with COVID-19 without supplemental oxygen requirement on admission during Hong Kong's omicron BA.2 wave: a retrospective cohort study, Lancet Infect Dis
Wong, Au, Lau, Lau, Cowling et al., Real-world effectiveness of molnupiravir and nirmatrelvir plus ritonavir against mortality, hospitalisation, and in-hospital outcomes among community-dwelling, ambulatory patients with confirmed SARS-CoV-2 infection during the omicron wave in Hong Kong: an observational study, Lancet
Yang, Wang, Jiang, Zhang, Zhang et al., Oral azvudine for mild-to-moderate COVID-19 in high risk, nonhospitalized adults: results of a real-world study, J Med Virol
Yu, Chang, Azvudine (FNC): a promising clinical candidate for COVID-19 treatment, Signal Transduct Target Therapy
Zhang, Li, Wang, Liu, Lu et al., Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients, Signal Transduct Target Ther
Zhao, Zheng, Han, Feng, Xia et al., Is azvudine comparable to nirmatrelvir-ritonavir in real-world efficacy and safety for hospitalized patients with COVID-19? A retrospective cohort study, Infect Dis Ther
Zhou, Liu, Jiang, Zhang, Zhang et al., -to-severe covid-19: emulation of a randomised target trial
Zong, Zhou, Li, Jiang, Liu et al., Azvudine reduces the in-hospital mortality of COVID-19 patients: a retrospective cohort study, Acta Pharm Sinica B
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop