A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 2 Study to Investigate the Efficacy and Safety of BGE-175 in Hospitalized Adults With COVID-19

Wilkerson et al., NCT04705597, NCT04705597, May 2022
Mortality -63% improvement lower risk ← → higher risk ICU admission -32% Severe case, critical -24% Time to improvement -33% Progression -23% Asapiprant  Wilkerson et al.  LATE TREATMENT RCT Is late treatment with asapiprant beneficial for COVID-19? Double-blind RCT 194 patients in the USA Higher mortality (p=0.21) and ICU admission (p=0.37), not sig. c19early.org Wilkerson et al., NCT04705597, May 2022 0 0.5 1 1.5 2+ RR
RCT 194 hospitalized COVID-19 patients showing no significant differences with asapiprant (BGE-175).
Standard of Care (SOC) for COVID-19 in the study country, the USA, is very poor with very low average efficacy for approved treatments1. Only expensive, high-profit treatments were approved for early treatment. Low-cost treatments were excluded, reducing the probability of early treatment due to access and cost barriers, and eliminating complementary and synergistic benefits seen with many low-cost treatments.
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risk of death, 63.3% higher, RR 1.63, p = 0.21, treatment 16 of 96 (16.7%), control 10 of 98 (10.2%).
risk of ICU admission, 32.1% higher, RR 1.32, p = 0.37, treatment 22 of 96 (22.9%), control 17 of 98 (17.3%).
risk of severe case, 24.0% higher, RR 1.24, p = 0.36, treatment 34 of 96 (35.4%), control 28 of 98 (28.6%).
time to improvement, 33.3% higher, relative time 1.33, p = 0.17, treatment mean 8.0 (±10.0) n=96, control mean 6.0 (±10.1) n=98.
risk of progression, 23.0% higher, RR 1.23, p = 0.43, treatment 31 of 94 (33.0%), control 26 of 97 (26.8%), death or respiratory failure.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Wilkerson et al., 19 May 2022, Double Blind Randomized Controlled Trial, placebo-controlled, USA, preprint, 1 author, critical, trial NCT04705597 (history). Contact: patrick@bioagelabs.com.
$0 $500 $1,000+ Efficacy vs. cost for COVID-19 treatment protocols c19early.org November 2025 USA Russia Sudan Angola Colombia Kenya Mozambique Vietnam Peru Philippines Spain Brazil Italy France Japan Canada China Uzbekistan Nepal Ethiopia Iran Ghana Mexico South Korea Germany Bangladesh Saudi Arabia Algeria Morocco Yemen Poland India DR Congo Madagascar Thailand Uganda Venezuela Nigeria Egypt Bolivia Taiwan Zambia Fiji Bosnia-Herzegovina Ukraine Côte d'Ivoire Bulgaria Greece Slovakia Singapore Iceland New Zealand Czechia Mongolia Israel Trinidad and Tobago Hong Kong North Macedonia Belarus Qatar Panama Serbia CAR USA favored high-profit treatments.The average efficacy of treatments was very low.High-cost protocols reduce early treatment, andforgo complementary/synergistic benefits. More effective More expensive 75% 50% 25% ≤0%
$0 $500 $1,000+ Efficacy vs. cost for COVID-19treatment protocols worldwide c19early.org November 2025 USA Russia Sudan Angola Colombia Kenya Mozambique Vietnam Peru Philippines Spain Brazil Italy France Japan Canada China Uzbekistan Nepal Ethiopia Iran Ghana Mexico South Korea Germany Bangladesh Saudi Arabia Algeria Morocco Yemen Poland India DR Congo Madagascar Thailand Uganda Venezuela Nigeria Egypt Bolivia Taiwan Zambia Fiji Ukraine Côte d'Ivoire Eritrea Bulgaria Greece Slovakia Singapore New Zealand Malawi Czechia Mongolia Israel Trinidad and Tobago North Macedonia Belarus Qatar Panama Serbia Syria USA favored high-profit treatments.The average efficacy was very low.High-cost protocols reduce early treatment,and forgo complementary/synergistic benefits. More effective More expensive 75% 50% 25% ≤0%
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 200,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
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