Analgesics
Antiandrogens
Antihistamines
Budesonide
Colchicine
Conv. Plasma
Curcumin
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Monoclonals
Mpro inhibitors
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Quercetin
RdRp inhibitors
TMPRSS2 inh.
Thermotherapy
Vitamins
More

Other
Feedback
Home
 
next
study
previous
study
c19early.org COVID-19 treatment researchEfzofitimodEfzofitimod (more..)
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta
Ivermectin Meta
Thermotherapy Meta
Melatonin Meta
Metformin Meta

 

A Randomized Double-Blind Placebo-Controlled Study to Evaluate the Safety and Efficacy of ATYR1923 In Adult Patients With Severe Pneumonia Related to SARS-CoV-2 Infection (COVID-19)

Walker et al., NCT04412668, NCT04412668, Oct 2020
https://c19early.org/walker2.html
Mortality -291% improvement lower risk ← → higher risk Hospitalization time.. -24% Hospitalization time.. b -22% Hospitalization time.. c -56% Recovery, both arms.. -11% Recovery, 3 mg/kg, da.. 17% Recovery, 1 mg/kg, da.. -67% Recovery, both arm.. b -7% Recovery, 3 mg/kg.. b 20% Recovery, 1 mg/kg.. b -60% Efzofitimod  Walker et al.  LATE TREATMENT RCT Is late treatment with efzofitimod beneficial for COVID-19? Double-blind RCT 32 patients in the USA Longer hospitalization with efzofitimod (not stat. sig., p=0.53) c19early.org Walker et al., NCT04412668, October 2020 0 0.5 1 1.5 2+ RR
RCT 32 hospitalized COVID-19 patients showing no significant differences with efzofitimod.
Standard of Care (SOC) for COVID-19 in the study country, the USA, is very poor with very low average efficacy for approved treatments1. Only expensive, high-profit treatments were approved for early treatment. Low-cost treatments were excluded, reducing the probability of early treatment due to access and cost barriers, and eliminating complementary and synergistic benefits seen with many low-cost treatments.
risk of death, 290.9% higher, RR 3.91, p = 1.00, treatment 2 of 22 (9.1%), control 0 of 10 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
hospitalization time, 24.4% higher, relative time 1.24, p = 0.53, treatment 12, control 10, both arms.
hospitalization time, 22.2% higher, relative time 1.22, p = 0.58, treatment mean 5.5 (±3.53) n=12, control mean 4.5 (±4.84) n=10.
hospitalization time, 55.6% higher, relative time 1.56, p = 0.74, treatment mean 7.0 (±22.6) n=10, control mean 4.5 (±4.84) n=10.
risk of no recovery, 11.1% higher, RR 1.11, p = 1.00, treatment 2 of 18 (11.1%), control 1 of 10 (10.0%), both arms, day 28.
risk of no recovery, 16.7% lower, RR 0.83, p = 1.00, treatment 1 of 12 (8.3%), control 1 of 10 (10.0%), NNT 60, 3 mg/kg, day 28.
risk of no recovery, 66.7% higher, RR 1.67, p = 1.00, treatment 1 of 6 (16.7%), control 1 of 10 (10.0%), 1 mg/kg, day 28.
risk of no recovery, 6.7% higher, RR 1.07, p = 1.00, treatment 2 of 15 (13.3%), control 1 of 8 (12.5%), both arms, day 14.
risk of no recovery, 20.0% lower, RR 0.80, p = 1.00, treatment 1 of 10 (10.0%), control 1 of 8 (12.5%), NNT 40, 3 mg/kg, day 14.
risk of no recovery, 60.0% higher, RR 1.60, p = 1.00, treatment 1 of 5 (20.0%), control 1 of 8 (12.5%), 1 mg/kg, day 14.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Walker et al., 23 Oct 2020, Double Blind Randomized Controlled Trial, placebo-controlled, USA, preprint, 1 author, trial NCT04412668 (history). Contact: clinicaltrials@atyrpharma.com.
$0 $500 $1,000+ Efficacy vs. cost for COVID-19 treatment protocols c19early.org November 2025 USA Russia Sudan Angola Colombia Kenya Mozambique Vietnam Peru Philippines Spain Brazil Italy France Japan Canada China Uzbekistan Nepal Ethiopia Iran Ghana Mexico South Korea Germany Bangladesh Saudi Arabia Algeria Morocco Yemen Poland India DR Congo Madagascar Thailand Uganda Venezuela Nigeria Egypt Bolivia Taiwan Zambia Fiji Bosnia-Herzegovina Ukraine Côte d'Ivoire Bulgaria Greece Slovakia Singapore Iceland New Zealand Czechia Mongolia Israel Trinidad and Tobago Hong Kong North Macedonia Belarus Qatar Panama Serbia CAR USA favored high-profit treatments.The average efficacy of treatments was very low.High-cost protocols reduce early treatment, andforgo complementary/synergistic benefits. More effective More expensive 75% 50% 25% ≤0%
$0 $500 $1,000+ Efficacy vs. cost for COVID-19treatment protocols worldwide c19early.org November 2025 USA Russia Sudan Angola Colombia Kenya Mozambique Vietnam Peru Philippines Spain Brazil Italy France Japan Canada China Uzbekistan Nepal Ethiopia Iran Ghana Mexico South Korea Germany Bangladesh Saudi Arabia Algeria Morocco Yemen Poland India DR Congo Madagascar Thailand Uganda Venezuela Nigeria Egypt Bolivia Taiwan Zambia Fiji Ukraine Côte d'Ivoire Eritrea Bulgaria Greece Slovakia Singapore New Zealand Malawi Czechia Mongolia Israel Trinidad and Tobago North Macedonia Belarus Qatar Panama Serbia Syria USA favored high-profit treatments.The average efficacy was very low.High-cost protocols reduce early treatment,and forgo complementary/synergistic benefits. More effective More expensive 75% 50% 25% ≤0%
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 200,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
  or use drag and drop   
Submit