Stauning et al., COVID-19 mortality among selective serotonin reuptake inhibitor users - Results from a nationwide cohort, Clinical Microbiology and Infection, doi:10.1016/j.cmi.2023.04.028
Retrospective 7,113 COVID+ SSRI users and 279,334 COVID+ non-SSRI users in Denmark, showing lower mortality with fluoxetine, without statistical significance, but higher mortality for other SSRIs.
risk of death, 57.7% lower, HR 0.42, p = 0.39, NNT 182, adjusted per study, odds ratio converted to relative risk, fluoxetine, multivariable, Cox proportional hazards.
risk of progression, 44.5% lower, HR 0.55, p = 0.30, adjusted per study, odds ratio converted to relative risk, fluoxetine, severe acute respiratory syndrome or death, multivariable, Cox proportional hazards.
risk of progression, 10.8% lower, HR 0.89, p = 0.84, adjusted per study, odds ratio converted to relative risk, fluoxetine, severe acute respiratory syndrome, multivariable, Cox proportional hazards.
risk of death, 31.6% higher, HR 1.32, p = 0.01, adjusted per study, odds ratio converted to relative risk, all SSRIs, multivariable, Cox proportional hazards.
risk of progression, 22.5% higher, HR 1.22, p < 0.001, adjusted per study, odds ratio converted to relative risk, all SSRIs, severe acute respiratory syndrome or death, multivariable, Cox proportional hazards.
risk of progression, 6.9% higher, HR 1.07, p = 0.40, adjusted per study, odds ratio converted to relative risk, all SSRIs, severe acute respiratory syndrome, multivariable, Cox proportional hazards.
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