Mortality Risk Among Patients With COVID-19 Prescribed Selective Serotonin Reuptake Inhibitor Antidepressants

DOI record: { "DOI": "10.1001/jamanetworkopen.2021.33090", "ISSN": [ "2574-3805" ], "URL": "http://dx.doi.org/10.1001/jamanetworkopen.2021.33090", "author": [ { "affiliation": [ { "name": "Department of Pediatrics, University of California, San Francisco" }, { "name": "Bakar Computational Health Sciences Institute, University of California, San Francisco" } ], "family": "Oskotsky", "given": "Tomiko", "sequence": "first" }, { "affiliation": [ { "name": "Department of Pediatrics, Stanford University School of Medicine, Stanford, California" } ], "family": "Marić", "given": "Ivana", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Pediatrics, University of California, San Francisco" }, { "name": "Bakar Computational Health Sciences Institute, University of California, San Francisco" }, { "name": "Graduate Program in Bioengineering, University of California, San Francisco" } ], "family": "Tang", "given": "Alice", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Pediatrics, University of California, San Francisco" }, { "name": "Bakar Computational Health Sciences Institute, University of California, San Francisco" } ], "family": "Oskotsky", "given": "Boris", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Pediatrics, Stanford University School of Medicine, Stanford, California" } ], "family": "Wong", "given": "Ronald J.", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Pediatrics, Stanford University School of Medicine, Stanford, California" }, { "name": "Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California" }, { "name": "Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, California" } ], "family": "Aghaeepour", "given": "Nima", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Pediatrics, University of California, San Francisco" }, { "name": "Bakar Computational Health Sciences Institute, University of California, San Francisco" } ], "family": "Sirota", "given": "Marina", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Pediatrics, Stanford University School of Medicine, Stanford, California" }, { "name": "Center for Academic Medicine, Stanford University School of Medicine, Stanford, California" } ], "family": "Stevenson", "given": "David K.", "sequence": "additional" } ], "container-title": [ "JAMA Network Open" ], "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2021, 11, 15 ] ], "date-time": "2021-11-15T16:35:47Z", "timestamp": 1636994147000 }, "deposited": { "date-parts": [ [ 2021, 11, 15 ] ], "date-time": "2021-11-15T16:35:57Z", "timestamp": 1636994157000 }, "indexed": { "date-parts": [ [ 2021, 11, 16 ] ], "date-time": "2021-11-16T10:40:04Z", "timestamp": 1637059204295 }, "is-referenced-by-count": 0, "issn-type": [ { "type": "electronic", "value": "2574-3805" } ], "issue": "11", "issued": { "date-parts": [ [ 2021, 11, 15 ] ] }, "journal-issue": { "issue": "11", "published-print": { "date-parts": [ [ 2021, 11, 1 ] ] } }, "language": "en", "link": [ { "URL": "https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2786136/oskotsky_2021_oi_210938_1636051230.14579.pdf", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "10", "original-title": [], "page": "e2133090", "prefix": "10.1001", "published": { "date-parts": [ [ 2021, 11, 15 ] ] }, "published-online": { "date-parts": [ [ 2021, 11, 15 ] ] }, "publisher": "American Medical Association (AMA)", "reference": [ { "DOI": "10.1001/jama.2020.22760", "article-title": "Fluvoxamine vs placebo and clinical deterioration in outpatients with symptomatic COVID-19: a randomized clinical trial.", "author": "Lenze", "doi-asserted-by": "publisher", "first-page": "2292", "issue": "22", "journal-title": "JAMA", "key": "zoi210938r2", "volume": "324", "year": "2020" }, { "DOI": "10.1093/ofid/ofab050", "article-title": "Prospective cohort of fluvoxamine for early treatment of coronavirus disease 19.", "author": "Seftel", "doi-asserted-by": "publisher", "first-page": "b050", "issue": "2", "journal-title": "Open Forum Infect Dis", "key": "zoi210938r3", "volume": "8", "year": "2021" }, { "DOI": "10.3390/microorganisms9020339", "article-title": "Fluoxetine can inhibit SARS-CoV-2 in vitro.", "author": "Dechaumes", "doi-asserted-by": "publisher", "first-page": "339", "issue": "2", "journal-title": "Microorganisms", "key": "zoi210938r4", "volume": "9", "year": "2021" }, { "DOI": "10.1038/s41598-021-85049-0", "article-title": "The serotonin reuptake inhibitor fluoxetine inhibits SARS-CoV-2 in human lung tissue.", "author": "Zimniak", "doi-asserted-by": "publisher", "first-page": "5890", "issue": "1", "journal-title": "Sci Rep", "key": "zoi210938r5", "volume": "11", "year": "2021" }, { "DOI": "10.1016/j.biopha.2021.111437", "article-title": "Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infection.", "author": "Creeden", "doi-asserted-by": "crossref", "journal-title": "Biomed Pharmacother", "key": "zoi210938r6", "volume": "138", "year": "2021" }, { "DOI": "10.1016/j.cytogfr.2020.06.001", "article-title": "SARS-CoV-2 infection: the role of cytokines in COVID-19 disease.", "author": "Costela-Ruiz", "doi-asserted-by": "publisher", "first-page": "62", "journal-title": "Cytokine Growth Factor Rev", "key": "zoi210938r7", "volume": "54", "year": "2020" }, { "DOI": "10.4088/PCC.v05n0402", "article-title": "Trends in prescribing of selective serotonin reuptake inhibitors and other newer antidepressant agents in adult primary care.", "author": "Pirraglia", "doi-asserted-by": "publisher", "first-page": "153", "issue": "4", "journal-title": "Prim Care Companion J Clin Psychiatry", "key": "zoi210938r8", "volume": "5", "year": "2003" }, { "DOI": "10.3389/fpsyt.2020.00035", "article-title": "National prescription patterns of antidepressants in the treatment of adults with major depression in the US between 1996 and 2015: a population representative survey based analysis.", "author": "Luo", "doi-asserted-by": "publisher", "first-page": "35", "journal-title": "Front Psychiatry", "key": "zoi210938r9", "volume": "11", "year": "2020" }, { "DOI": "10.4088/JCP.10r06218blu", "article-title": "The pharmacologic treatment of anxiety disorders: a review of progress.", "author": "Ravindran", "doi-asserted-by": "publisher", "first-page": "839", "issue": "7", "journal-title": "J Clin Psychiatry", "key": "zoi210938r10", "volume": "71", "year": "2010" }, { "DOI": "10.1038/npp.2011.132", "article-title": "The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis.", "author": "Hannestad", "doi-asserted-by": "publisher", "first-page": "2452", "issue": "12", "journal-title": "Neuropsychopharmacology", "key": "zoi210938r11", "volume": "36", "year": "2011" }, { "DOI": "10.1002/art.27304", "article-title": "Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors.", "author": "Sacre", "doi-asserted-by": "publisher", "first-page": "683", "issue": "3", "journal-title": "Arthritis Rheum", "key": "zoi210938r12", "volume": "62", "year": "2010" }, { "article-title": "Pharmacological inhibition of acid sphingomyelinase prevents uptake of SARS-CoV-2 by epithelial cells.", "author": "Carpinteiro", "issue": "8", "journal-title": "Cell Rep Med", "key": "zoi210938r13", "volume": "1", "year": "2020" }, { "DOI": "10.1016/j.jbc.2021.100701", "article-title": "Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells.", "author": "Carpinteiro", "doi-asserted-by": "crossref", "journal-title": "J Biol Chem", "key": "zoi210938r14", "volume": "296", "year": "2021" }, { "DOI": "10.3390/ijms22094794", "article-title": "Metabolic signatures associated with severity in hospitalized COVID-19 patients.", "author": "Marín-Corral", "doi-asserted-by": "publisher", "first-page": "4794", "issue": "9", "journal-title": "Int J Mol Sci", "key": "zoi210938r15", "volume": "22", "year": "2021" }, { "article-title": "Association between FIASMAs and reduced risk of intubation or death in individuals hospitalized for severe COVID-19: an observational multicenter study.", "author": "Hoertel", "journal-title": "Clin Pharmacol Ther", "key": "zoi210938r16" }, { "DOI": "10.1016/S2215-0366(20)30462-4", "article-title": "Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62?354 COVID-19 cases in the USA.", "author": "Taquet", "doi-asserted-by": "publisher", "first-page": "130", "issue": "2", "journal-title": "Lancet Psychiatry", "key": "zoi210938r19", "volume": "8", "year": "2021" }, { "DOI": "10.1111/acps.v143.6", "article-title": "Mental disorders, psychopharmacological treatments, and mortality in 2150 COVID-19 Spanish inpatients.", "author": "Diez-Quevedo", "doi-asserted-by": "publisher", "first-page": "526", "issue": "6", "journal-title": "Acta Psychiatr Scand", "key": "zoi210938r20", "volume": "143", "year": "2021" }, { "DOI": "10.1016/S0140-6736(07)61602-X", "article-title": "The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.", "author": "von Elm", "doi-asserted-by": "publisher", "first-page": "1453", "issue": "9596", "journal-title": "Lancet", "key": "zoi210938r22", "volume": "370", "year": "2007" }, { "DOI": "10.1002/sim.v33.24", "article-title": "The use of bootstrapping when using propensity-score matching without replacement: a simulation study.", "author": "Austin", "doi-asserted-by": "publisher", "first-page": "4306", "issue": "24", "journal-title": "Stat Med", "key": "zoi210938r24", "volume": "33", "year": "2014" }, { "DOI": "10.1016/j.jad.2015.03.021", "article-title": "Dose equivalents of antidepressants: evidence-based recommendations from randomized controlled trials.", "author": "Hayasaka", "doi-asserted-by": "publisher", "first-page": "179", "journal-title": "J Affect Disord", "key": "zoi210938r25", "volume": "180", "year": "2015" }, { "DOI": "10.1016/S2215-0366(19)30217-2", "article-title": "Optimal dose of selective serotonin reuptake inhibitors, venlafaxine, and mirtazapine in major depression: a systematic review and dose-response meta-analysis.", "author": "Furukawa", "doi-asserted-by": "publisher", "first-page": "601", "issue": "7", "journal-title": "Lancet Psychiatry", "key": "zoi210938r26", "volume": "6", "year": "2019" }, { "DOI": "10.1016/j.mehy.2020.110140", "article-title": "The possible immunoregulatory and anti-inflammatory effects of selective serotonin reuptake inhibitors in coronavirus disease patients.", "author": "Hamed", "doi-asserted-by": "crossref", "journal-title": "Med Hypotheses", "key": "zoi210938r28", "volume": "144", "year": "2020" }, { "DOI": "10.1016/j.jocn.2021.03.010", "article-title": "Drug repurposing of selective serotonin reuptake inhibitors: could these drugs help fight COVID-19 and save lives?", "author": "Pashaei", "doi-asserted-by": "crossref", "first-page": "163", "issue": "0", "journal-title": "J Clin Neurosci", "key": "zoi210938r29", "volume": "88", "year": "2021" }, { "DOI": "10.1016/j.coph.2011.02.004", "article-title": "5-HT and the immune system.", "author": "Ahern", "doi-asserted-by": "publisher", "first-page": "29", "issue": "1", "journal-title": "Curr Opin Pharmacol", "key": "zoi210938r30", "volume": "11", "year": "2011" }, { "article-title": "Peripheral alterations in cytokine and chemokine levels after antidepressant drug treatment for major depressive disorder: systematic review and meta-analysis.", "author": "Köhler", "first-page": "4195", "issue": "5", "journal-title": "Mol Neurobiol", "key": "zoi210938r31", "volume": "55", "year": "2018" }, { "DOI": "10.1111/j.1749-6632.1995.tb32372.x", "article-title": "Interleukin-6 serum levels in depressed patients before and after treatment with fluoxetine.", "author": "Sluzewska", "doi-asserted-by": "publisher", "first-page": "474", "issue": "1", "journal-title": "Ann N Y Acad Sci", "key": "zoi210938r32", "volume": "762", "year": "1995" }, { "DOI": "10.1016/j.ejphar.2014.01.064", "article-title": "Interaction of new antidepressants with sigma-1 receptor chaperones and their potentiation of neurite outgrowth in PC12 cells.", "author": "Ishima", "doi-asserted-by": "publisher", "first-page": "167", "journal-title": "Eur J Pharmacol", "key": "zoi210938r33", "volume": "727", "year": "2014" }, { "DOI": "10.1016/S0924-8579(99)00157-0", "article-title": "Inhibition of HIV replication by neuroleptic agents and their potential use in HIV infected patients with AIDS related dementia.", "author": "Kristiansen", "doi-asserted-by": "publisher", "first-page": "209", "issue": "3", "journal-title": "Int J Antimicrob Agents", "key": "zoi210938r34", "volume": "14", "year": "2000" }, { "DOI": "10.1128/AAC.00983-12", "article-title": "Fluoxetine is a potent inhibitor of coxsackievirus replication.", "author": "Zuo", "doi-asserted-by": "publisher", "first-page": "4838", "issue": "9", "journal-title": "Antimicrob Agents Chemother", "key": "zoi210938r35", "volume": "56", "year": "2012" }, { "DOI": "10.1038/s41380-021-01021-4", "article-title": "Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study.", "author": "Hoertel", "doi-asserted-by": "crossref", "key": "zoi210938r1", "volume-title": "Mol Psychiatry" }, { "DOI": "10.1101/2021.02.18.21251997", "doi-asserted-by": "crossref", "key": "zoi210938r17", "unstructured": "Hoertel? N, Sánchez-Rico? M, Gulbins? E, . Association between psychotropic medications functionally inhibiting acid sphingomyelinase and reduced risk of intubation or death among individuals with mental disorder and severe COVID-19: an observational study.? medRxiv. Preprint posted online February 20, 2021. doi:10.1101/2021.02.18.21251997" }, { "DOI": "10.1002/wps.20806", "doi-asserted-by": "crossref", "key": "zoi210938r18", "unstructured": "Wang QQ, Xu R, Volkow ND. Increased risk of COVID-19 infection and mortality in people with mental disorders: analysis from electronic health records in the United States. World Psychiatry. Published online October 7, 2020. Accessed September 3, 2021. https://onlinelibrary.wiley.com/doi/full/10.1002/wps.20806" }, { "DOI": "10.1101/2021.04.24.21256029", "doi-asserted-by": "crossref", "key": "zoi210938r21", "unstructured": "Günster? C, Busse? R, Spoden? M, . 6-Month follow up of 8679 hospitalized COVID-19 patients in Germany: a nationwide cohort study.? medRxiv. Preprint posted online April 24, 2012. doi:10.1101/2021.04.24.21256029" }, { "key": "zoi210938r23", "unstructured": "ICD-10 Version:2019. Updated April 16, 2020. Accessed August 9, 2021. https://icd.who.int/browse10/2019/en#/U07.1" }, { "key": "zoi210938r27", "unstructured": "CDC/National Center for Health Statistics. Antidepressant use among adults: United States, 2015-2018. September 8, 2020. Accessed September 3, 2021. https://www.cdc.gov/nchs/products/databriefs/db377.htm" } ], "reference-count": 35, "references-count": 35, "relation": {}, "score": 1, "short-container-title": [ "JAMA Netw Open" ], "short-title": [], "source": "Crossref", "subject": [ "General Medicine" ], "subtitle": [], "title": [ "Mortality Risk Among Patients With COVID-19 Prescribed Selective Serotonin Reuptake Inhibitor Antidepressants" ], "type": "journal-article", "volume": "4" }